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Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes.
Br J Nutr. 2009 Jan; 101(1):20-6.BJ

Abstract

The present study gives further evidence for the recently found association between variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and PUFA in blood phospholipids and explores this association for cellular fatty acids in erythrocyte membranes. In a subgroup of adults participating in the Bavarian Nutrition Survey II, a cross-sectional population-based study conducted in Bavaria, Germany, allelic variation in three selected loci of the FADS1 FADS2 gene cluster was analysed and used for haplotype construction. Associations with plasma phospholipid PUFA (n 163) and PUFA in erythrocyte membranes (n 535) were investigated by regression analysis. All haplotypes of the original five-loci haplotypes of our previous study could be replicated. In addition, associations with serum phospholipid PUFA were confirmed in the present data set. Although less pronounced, associations between FADS1 FADS2 haplotypes and PUFA in erythrocyte membranes, particularly arachidonic and dihomo-gamma-linolenic acid, could be established. We provide the first replication of the association of the FADS1 FADS2 gene cluster with PUFA in blood phospholipids. For the first time, such associations were also shown for PUFA in cell membranes.

Authors+Show Affiliations

Institute of Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg 85764, Germany. peter.rzehak@helmholtz-muenchen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18479586

Citation

Rzehak, Peter, et al. "Evidence for an Association Between Genetic Variants of the Fatty Acid Desaturase 1 Fatty Acid Desaturase 2 (FADS1 FADS2) Gene Cluster and the Fatty Acid Composition of Erythrocyte Membranes." The British Journal of Nutrition, vol. 101, no. 1, 2009, pp. 20-6.
Rzehak P, Heinrich J, Klopp N, et al. Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes. Br J Nutr. 2009;101(1):20-6.
Rzehak, P., Heinrich, J., Klopp, N., Schaeffer, L., Hoff, S., Wolfram, G., Illig, T., & Linseisen, J. (2009). Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes. The British Journal of Nutrition, 101(1), 20-6. https://doi.org/10.1017/S0007114508992564
Rzehak P, et al. Evidence for an Association Between Genetic Variants of the Fatty Acid Desaturase 1 Fatty Acid Desaturase 2 (FADS1 FADS2) Gene Cluster and the Fatty Acid Composition of Erythrocyte Membranes. Br J Nutr. 2009;101(1):20-6. PubMed PMID: 18479586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes. AU - Rzehak,Peter, AU - Heinrich,Joachim, AU - Klopp,Norman, AU - Schaeffer,Linda, AU - Hoff,Sebastian, AU - Wolfram,Günther, AU - Illig,Thomas, AU - Linseisen,Jakob, Y1 - 2008/05/15/ PY - 2008/5/16/pubmed PY - 2009/6/2/medline PY - 2008/5/16/entrez SP - 20 EP - 6 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 101 IS - 1 N2 - The present study gives further evidence for the recently found association between variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and PUFA in blood phospholipids and explores this association for cellular fatty acids in erythrocyte membranes. In a subgroup of adults participating in the Bavarian Nutrition Survey II, a cross-sectional population-based study conducted in Bavaria, Germany, allelic variation in three selected loci of the FADS1 FADS2 gene cluster was analysed and used for haplotype construction. Associations with plasma phospholipid PUFA (n 163) and PUFA in erythrocyte membranes (n 535) were investigated by regression analysis. All haplotypes of the original five-loci haplotypes of our previous study could be replicated. In addition, associations with serum phospholipid PUFA were confirmed in the present data set. Although less pronounced, associations between FADS1 FADS2 haplotypes and PUFA in erythrocyte membranes, particularly arachidonic and dihomo-gamma-linolenic acid, could be established. We provide the first replication of the association of the FADS1 FADS2 gene cluster with PUFA in blood phospholipids. For the first time, such associations were also shown for PUFA in cell membranes. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/18479586/Evidence_for_an_association_between_genetic_variants_of_the_fatty_acid_desaturase_1_fatty_acid_desaturase_2__FADS1_FADS2__gene_cluster_and_the_fatty_acid_composition_of_erythrocyte_membranes_ L2 - https://www.cambridge.org/core/product/identifier/S0007114508992564/type/journal_article DB - PRIME DP - Unbound Medicine ER -