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[Correlations of high-risk human papillomaviral load to cervical intraepithelial neoplasia grades, expression of Ki-67 and P6ink4a and follow-up].
Ai Zheng 2008; 27(5):520-4AZ

Abstract

BACKGROUND & OBJECTIVE

It is well known that high-risk human papillomavirus (HPV) infection is the major cause of cervical cancer. However, the relation between cervical cancer and high-risk HPV load is uncertain, and there are only a small number of reports studying the correlation between high-risk HPV load and tumor markers. This study was to investigate the correlations of high-risk HPV load to the grade of cervical intraepithelial neoplasia (CIN), expression of Ki-67 and p16ink4a in the cervical lesion, and the abnormal cytology after surgery.

METHODS

The expression of Ki-67 and p16ink4a in 8 specimens of CINI, 12 specimens of CINII, and 41 specimens of CINIII were detected by immunohistochemistry. All the patients received high-risk HPV load detection using hybrid captureII (HCII) before operation and were followed up afterwards.

RESULTS

The high-risk HPV load was positively correlated to the CIN grade and expression of Ki-67 and p16ink4a슩 with correlation coefficients of 0.288, 0.318, and 0.336, respectively (P<0.05). After a mean follow-up of 18.5 months, 6 patients were found abnormal cytological smears again, whose HPV loads were over 100 RLU/ PC before operation. Five out of the 6 patients had the HPV loads between 100 to 1000 RLU/ PC before operation and the remaining one had the HPV load of over 1000 RLU/PC. However, no statistical differences were observed among the 3 groups of different viral loads (<100 RLU/PC, 100 to <1 000 RLU/PC, > or =1 000 RLU/PC). Age, parity, CIN grades, expression of p16ink4a and Ki-67 had no predictive significance for the abnormal cytology after operation.

CONCLUSIONS

The high-risk HPV load has positive correlation to the progression of cervical lesion and increased malignancy of cells. Although the high-risk HPV load have no relation to the abnormal cytology after operation, patients with the viral load of over 100 RLU/PC should be paid more attention.

Authors+Show Affiliations

Department of Gynecology, Peking University People's Hospital, Beijing, 100044, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

18479603

Citation

Yi, Wei, et al. "[Correlations of High-risk Human Papillomaviral Load to Cervical Intraepithelial Neoplasia Grades, Expression of Ki-67 and P6ink4a and Follow-up]." Ai Zheng = Aizheng = Chinese Journal of Cancer, vol. 27, no. 5, 2008, pp. 520-4.
Yi W, Wang JL, Li XH, et al. [Correlations of high-risk human papillomaviral load to cervical intraepithelial neoplasia grades, expression of Ki-67 and P6ink4a and follow-up]. Ai Zheng. 2008;27(5):520-4.
Yi, W., Wang, J. L., Li, X. H., & Wei, L. H. (2008). [Correlations of high-risk human papillomaviral load to cervical intraepithelial neoplasia grades, expression of Ki-67 and P6ink4a and follow-up]. Ai Zheng = Aizheng = Chinese Journal of Cancer, 27(5), pp. 520-4.
Yi W, et al. [Correlations of High-risk Human Papillomaviral Load to Cervical Intraepithelial Neoplasia Grades, Expression of Ki-67 and P6ink4a and Follow-up]. Ai Zheng. 2008;27(5):520-4. PubMed PMID: 18479603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Correlations of high-risk human papillomaviral load to cervical intraepithelial neoplasia grades, expression of Ki-67 and P6ink4a and follow-up]. AU - Yi,Wei, AU - Wang,Jian-Liu, AU - Li,Xing-Hong, AU - Wei,Li-Hui, PY - 2008/5/16/pubmed PY - 2010/4/28/medline PY - 2008/5/16/entrez SP - 520 EP - 4 JF - Ai zheng = Aizheng = Chinese journal of cancer JO - Ai Zheng VL - 27 IS - 5 N2 - BACKGROUND & OBJECTIVE: It is well known that high-risk human papillomavirus (HPV) infection is the major cause of cervical cancer. However, the relation between cervical cancer and high-risk HPV load is uncertain, and there are only a small number of reports studying the correlation between high-risk HPV load and tumor markers. This study was to investigate the correlations of high-risk HPV load to the grade of cervical intraepithelial neoplasia (CIN), expression of Ki-67 and p16ink4a in the cervical lesion, and the abnormal cytology after surgery. METHODS: The expression of Ki-67 and p16ink4a in 8 specimens of CINI, 12 specimens of CINII, and 41 specimens of CINIII were detected by immunohistochemistry. All the patients received high-risk HPV load detection using hybrid captureII (HCII) before operation and were followed up afterwards. RESULTS: The high-risk HPV load was positively correlated to the CIN grade and expression of Ki-67 and p16ink4a슩 with correlation coefficients of 0.288, 0.318, and 0.336, respectively (P<0.05). After a mean follow-up of 18.5 months, 6 patients were found abnormal cytological smears again, whose HPV loads were over 100 RLU/ PC before operation. Five out of the 6 patients had the HPV loads between 100 to 1000 RLU/ PC before operation and the remaining one had the HPV load of over 1000 RLU/PC. However, no statistical differences were observed among the 3 groups of different viral loads (<100 RLU/PC, 100 to <1 000 RLU/PC, > or =1 000 RLU/PC). Age, parity, CIN grades, expression of p16ink4a and Ki-67 had no predictive significance for the abnormal cytology after operation. CONCLUSIONS: The high-risk HPV load has positive correlation to the progression of cervical lesion and increased malignancy of cells. Although the high-risk HPV load have no relation to the abnormal cytology after operation, patients with the viral load of over 100 RLU/PC should be paid more attention. UR - https://www.unboundmedicine.com/medline/citation/18479603/[Correlations_of_high_risk_human_papillomaviral_load_to_cervical_intraepithelial_neoplasia_grades_expression_of_Ki_67_and_P6ink4a_and_follow_up]_ L2 - http://www.diseaseinfosearch.org/result/1266 DB - PRIME DP - Unbound Medicine ER -