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Modulation of morphine state-dependent learning by muscarinic cholinergic receptors of the ventral tegmental area.
Physiol Behav. 2008 Jul 05; 94(4):604-10.PB

Abstract

In the present study, the effects of bilateral intra-ventral tegmental area (intra-VTA) injections of an anticholinesterase, physostigmine and/or muscarinic acetylcholine receptor antagonist, atropine on memory retention and morphine state-dependent learning were examined in adult male Wistar rats. As a model of learning, a step-through passive avoidance task was used. Post-training subcutaneous administration of morphine (0.5, 2.5 and 5 mg/kg) dose-dependently impaired memory retrieval on the test day. Pre-test administration of morphine (2.5 and 5 mg/kg) induced state-dependent retrieval of the memory acquired under post-training morphine influence. Pre-test intra-VTA microinjection of physostigmine (0.5, 1 and 2 microg/rat) or atropine (1, 2 and 3 microg/rat) alone cannot affect memory retention. Interestingly, pre-test intra-VTA administration of physostigmine (1 and 2 microg/rat) reversed post-training morphine (5 mg/kg, s.c.)-induced retrieval impairment. Furthermore, pre-test intra-VTA microinjection of physostigmine (1 and 2 mug/rat) with an ineffective dose of morphine (0.5 mg/kg), synergistically improved memory performance impaired by post-training morphine. On the other hand, pre-test intra-VTA microinjection of atropine (2 and 3 microg/rat) 5 min before the administration of morphine (5 mg/kg, s.c.) dose-dependently inhibited morphine state-dependent memory. Pre-test atropine microinjection also reversed the influence of physostigmine on morphine response. It may be concluded that the muscarinic acetylcholine receptors of the VTA play an important role in morphine-induced recovery of memory, on the test day.

Authors+Show Affiliations

Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18479719

Citation

Darbandi, Niloufar, et al. "Modulation of Morphine State-dependent Learning By Muscarinic Cholinergic Receptors of the Ventral Tegmental Area." Physiology & Behavior, vol. 94, no. 4, 2008, pp. 604-10.
Darbandi N, Rezayof A, Zarrindast MR. Modulation of morphine state-dependent learning by muscarinic cholinergic receptors of the ventral tegmental area. Physiol Behav. 2008;94(4):604-10.
Darbandi, N., Rezayof, A., & Zarrindast, M. R. (2008). Modulation of morphine state-dependent learning by muscarinic cholinergic receptors of the ventral tegmental area. Physiology & Behavior, 94(4), 604-10. https://doi.org/10.1016/j.physbeh.2008.04.001
Darbandi N, Rezayof A, Zarrindast MR. Modulation of Morphine State-dependent Learning By Muscarinic Cholinergic Receptors of the Ventral Tegmental Area. Physiol Behav. 2008 Jul 5;94(4):604-10. PubMed PMID: 18479719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of morphine state-dependent learning by muscarinic cholinergic receptors of the ventral tegmental area. AU - Darbandi,Niloufar, AU - Rezayof,Ameneh, AU - Zarrindast,Mohammad-Reza, Y1 - 2008/04/08/ PY - 2007/07/24/received PY - 2008/03/13/revised PY - 2008/04/01/accepted PY - 2008/5/16/pubmed PY - 2008/9/5/medline PY - 2008/5/16/entrez SP - 604 EP - 10 JF - Physiology & behavior JO - Physiol Behav VL - 94 IS - 4 N2 - In the present study, the effects of bilateral intra-ventral tegmental area (intra-VTA) injections of an anticholinesterase, physostigmine and/or muscarinic acetylcholine receptor antagonist, atropine on memory retention and morphine state-dependent learning were examined in adult male Wistar rats. As a model of learning, a step-through passive avoidance task was used. Post-training subcutaneous administration of morphine (0.5, 2.5 and 5 mg/kg) dose-dependently impaired memory retrieval on the test day. Pre-test administration of morphine (2.5 and 5 mg/kg) induced state-dependent retrieval of the memory acquired under post-training morphine influence. Pre-test intra-VTA microinjection of physostigmine (0.5, 1 and 2 microg/rat) or atropine (1, 2 and 3 microg/rat) alone cannot affect memory retention. Interestingly, pre-test intra-VTA administration of physostigmine (1 and 2 microg/rat) reversed post-training morphine (5 mg/kg, s.c.)-induced retrieval impairment. Furthermore, pre-test intra-VTA microinjection of physostigmine (1 and 2 mug/rat) with an ineffective dose of morphine (0.5 mg/kg), synergistically improved memory performance impaired by post-training morphine. On the other hand, pre-test intra-VTA microinjection of atropine (2 and 3 microg/rat) 5 min before the administration of morphine (5 mg/kg, s.c.) dose-dependently inhibited morphine state-dependent memory. Pre-test atropine microinjection also reversed the influence of physostigmine on morphine response. It may be concluded that the muscarinic acetylcholine receptors of the VTA play an important role in morphine-induced recovery of memory, on the test day. SN - 0031-9384 UR - https://www.unboundmedicine.com/medline/citation/18479719/Modulation_of_morphine_state_dependent_learning_by_muscarinic_cholinergic_receptors_of_the_ventral_tegmental_area_ DB - PRIME DP - Unbound Medicine ER -