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Small cell carcinoma: arising in Lynch syndrome: a previously undocumented occurrence.
Int J Surg Pathol 2009; 17(1):46-50IJ

Abstract

Lynch syndrome is a genetic cancer predisposition syndrome caused by an inherited defect in 1 of 4 DNA mismatch repair genes (mutL homolog 1, mutS homolog 2, mutS homolog 6, and postmeiotic segregation 2). Despite the theoretically increased risk in all tissues, Lynch syndrome exhibits tissue specificity, with a particular tendency among affected individuals to develop colorectal and endometrial cancer at a young age. A number of other malignancies, including those derived from the ovary, stomach, small bowel, and urothelium, have also been linked to this syndrome. A growing body of evidence exists to support an association between mismatch repair mutations and a growing spectrum of hereditary nonpolyposis colon cancer-associated neoplasms. In this article, a previously undocumented mismatch repair-related malignancy in a patient with Lynch syndrome is reported.

Authors+Show Affiliations

Department of Pathology, University of New Mexico Health Sciences Center, 1 University of New Mexico, Albuquerque, New Mexico, USA. oman@salud.unm.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18480399

Citation

Oman, Sarah A., et al. "Small Cell Carcinoma: Arising in Lynch Syndrome: a Previously Undocumented Occurrence." International Journal of Surgical Pathology, vol. 17, no. 1, 2009, pp. 46-50.
Oman SA, Ballinger L, Cerilli LA. Small cell carcinoma: arising in Lynch syndrome: a previously undocumented occurrence. Int J Surg Pathol. 2009;17(1):46-50.
Oman, S. A., Ballinger, L., & Cerilli, L. A. (2009). Small cell carcinoma: arising in Lynch syndrome: a previously undocumented occurrence. International Journal of Surgical Pathology, 17(1), pp. 46-50. doi:10.1177/1066896908315820.
Oman SA, Ballinger L, Cerilli LA. Small Cell Carcinoma: Arising in Lynch Syndrome: a Previously Undocumented Occurrence. Int J Surg Pathol. 2009;17(1):46-50. PubMed PMID: 18480399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small cell carcinoma: arising in Lynch syndrome: a previously undocumented occurrence. AU - Oman,Sarah A, AU - Ballinger,Lori, AU - Cerilli,Lisa A, Y1 - 2008/05/14/ PY - 2008/5/16/pubmed PY - 2009/3/25/medline PY - 2008/5/16/entrez SP - 46 EP - 50 JF - International journal of surgical pathology JO - Int. J. Surg. Pathol. VL - 17 IS - 1 N2 - Lynch syndrome is a genetic cancer predisposition syndrome caused by an inherited defect in 1 of 4 DNA mismatch repair genes (mutL homolog 1, mutS homolog 2, mutS homolog 6, and postmeiotic segregation 2). Despite the theoretically increased risk in all tissues, Lynch syndrome exhibits tissue specificity, with a particular tendency among affected individuals to develop colorectal and endometrial cancer at a young age. A number of other malignancies, including those derived from the ovary, stomach, small bowel, and urothelium, have also been linked to this syndrome. A growing body of evidence exists to support an association between mismatch repair mutations and a growing spectrum of hereditary nonpolyposis colon cancer-associated neoplasms. In this article, a previously undocumented mismatch repair-related malignancy in a patient with Lynch syndrome is reported. SN - 1066-8969 UR - https://www.unboundmedicine.com/medline/citation/18480399/Small_cell_carcinoma:_arising_in_Lynch_syndrome:_a_previously_undocumented_occurrence_ L2 - http://journals.sagepub.com/doi/full/10.1177/1066896908315820?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -