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Small cell carcinoma: arising in Lynch syndrome: a previously undocumented occurrence.

Abstract

Lynch syndrome is a genetic cancer predisposition syndrome caused by an inherited defect in 1 of 4 DNA mismatch repair genes (mutL homolog 1, mutS homolog 2, mutS homolog 6, and postmeiotic segregation 2). Despite the theoretically increased risk in all tissues, Lynch syndrome exhibits tissue specificity, with a particular tendency among affected individuals to develop colorectal and endometrial cancer at a young age. A number of other malignancies, including those derived from the ovary, stomach, small bowel, and urothelium, have also been linked to this syndrome. A growing body of evidence exists to support an association between mismatch repair mutations and a growing spectrum of hereditary nonpolyposis colon cancer-associated neoplasms. In this article, a previously undocumented mismatch repair-related malignancy in a patient with Lynch syndrome is reported.

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  • Authors+Show Affiliations

    ,

    Department of Pathology, University of New Mexico Health Sciences Center, 1 University of New Mexico, Albuquerque, New Mexico, USA. oman@salud.unm.edu

    ,

    Source

    MeSH

    Adenocarcinoma
    Adult
    Carcinoma, Small Cell
    Colonic Neoplasms
    Colorectal Neoplasms, Hereditary Nonpolyposis
    DNA Mismatch Repair
    Endometrial Neoplasms
    Female
    Genetic Predisposition to Disease
    Humans
    Mediastinal Neoplasms
    Neoplasms, Multiple Primary
    Pedigree

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    18480399

    Citation

    Oman, Sarah A., et al. "Small Cell Carcinoma: Arising in Lynch Syndrome: a Previously Undocumented Occurrence." International Journal of Surgical Pathology, vol. 17, no. 1, 2009, pp. 46-50.
    Oman SA, Ballinger L, Cerilli LA. Small cell carcinoma: arising in Lynch syndrome: a previously undocumented occurrence. Int J Surg Pathol. 2009;17(1):46-50.
    Oman, S. A., Ballinger, L., & Cerilli, L. A. (2009). Small cell carcinoma: arising in Lynch syndrome: a previously undocumented occurrence. International Journal of Surgical Pathology, 17(1), pp. 46-50. doi:10.1177/1066896908315820.
    Oman SA, Ballinger L, Cerilli LA. Small Cell Carcinoma: Arising in Lynch Syndrome: a Previously Undocumented Occurrence. Int J Surg Pathol. 2009;17(1):46-50. PubMed PMID: 18480399.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Small cell carcinoma: arising in Lynch syndrome: a previously undocumented occurrence. AU - Oman,Sarah A, AU - Ballinger,Lori, AU - Cerilli,Lisa A, Y1 - 2008/05/14/ PY - 2008/5/16/pubmed PY - 2009/3/25/medline PY - 2008/5/16/entrez SP - 46 EP - 50 JF - International journal of surgical pathology JO - Int. J. Surg. Pathol. VL - 17 IS - 1 N2 - Lynch syndrome is a genetic cancer predisposition syndrome caused by an inherited defect in 1 of 4 DNA mismatch repair genes (mutL homolog 1, mutS homolog 2, mutS homolog 6, and postmeiotic segregation 2). Despite the theoretically increased risk in all tissues, Lynch syndrome exhibits tissue specificity, with a particular tendency among affected individuals to develop colorectal and endometrial cancer at a young age. A number of other malignancies, including those derived from the ovary, stomach, small bowel, and urothelium, have also been linked to this syndrome. A growing body of evidence exists to support an association between mismatch repair mutations and a growing spectrum of hereditary nonpolyposis colon cancer-associated neoplasms. In this article, a previously undocumented mismatch repair-related malignancy in a patient with Lynch syndrome is reported. SN - 1066-8969 UR - https://www.unboundmedicine.com/medline/citation/18480399/Small_cell_carcinoma:_arising_in_Lynch_syndrome:_a_previously_undocumented_occurrence_ L2 - http://journals.sagepub.com/doi/full/10.1177/1066896908315820?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -