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Trends in the postfortification prevalence of spina bifida and anencephaly in the United States.
Birth Defects Res A Clin Mol Teratol. 2008 Jul; 82(7):527-32.BD

Abstract

BACKGROUND

The prevalence of NTDs in the US declined significantly after mandatory folic acid fortification; however, it is not known if the prevalence of NTDs has continued to decrease in recent years relative to the period immediately following the fortification mandate.

METHODS

Population-based data from 21 birth defects surveillance systems were used to examine trends in the birth prevalence of spina bifida and anencephaly during 1999-2000, 2001-2002, and 2003-2004. Prevalence data were stratified by non-Hispanic White, non-Hispanic Black, and Hispanic race or ethnicity. Prevalence ratios were calculated by dividing the birth prevalences during the later time periods (2001-2002 and 2003-2004) by the birth prevalences during 1999-2000.

RESULTS

During 1999-2004, 3,311 cases of spina bifida and 2,116 cases of anencephaly were reported. Hispanic infants had the highest prevalences of NTDs for all years. For all infants, the combined birth prevalences of spina bifida and anencephaly decreased 10% from the 1999-2000 period to the 2003-2004 period. The decline in spina bifida (3%) was not significant; however the decline in anencephaly (20%) was statistically significant.

CONCLUSIONS

While the prevalences of spina bifida and anencephaly in the United States have declined since folic acid fortification in the food supply began, these data suggest that reductions in the prevalence of anencephaly continued during 2001-2004 and that racial and ethnic and other disparities remain.

Authors+Show Affiliations

National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia 30333, USA. sboulet@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

18481813

Citation

Boulet, Sheree L., et al. "Trends in the Postfortification Prevalence of Spina Bifida and Anencephaly in the United States." Birth Defects Research. Part A, Clinical and Molecular Teratology, vol. 82, no. 7, 2008, pp. 527-32.
Boulet SL, Yang Q, Mai C, et al. Trends in the postfortification prevalence of spina bifida and anencephaly in the United States. Birth Defects Res A Clin Mol Teratol. 2008;82(7):527-32.
Boulet, S. L., Yang, Q., Mai, C., Kirby, R. S., Collins, J. S., Robbins, J. M., Meyer, R., Canfield, M. A., & Mulinare, J. (2008). Trends in the postfortification prevalence of spina bifida and anencephaly in the United States. Birth Defects Research. Part A, Clinical and Molecular Teratology, 82(7), 527-32. https://doi.org/10.1002/bdra.20468
Boulet SL, et al. Trends in the Postfortification Prevalence of Spina Bifida and Anencephaly in the United States. Birth Defects Res A Clin Mol Teratol. 2008;82(7):527-32. PubMed PMID: 18481813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trends in the postfortification prevalence of spina bifida and anencephaly in the United States. AU - Boulet,Sheree L, AU - Yang,Quanhe, AU - Mai,Cara, AU - Kirby,Russell S, AU - Collins,Julianne S, AU - Robbins,James M, AU - Meyer,Robert, AU - Canfield,Mark A, AU - Mulinare,Joe, AU - ,, PY - 2008/5/17/pubmed PY - 2008/8/12/medline PY - 2008/5/17/entrez SP - 527 EP - 32 JF - Birth defects research. Part A, Clinical and molecular teratology JO - Birth Defects Res A Clin Mol Teratol VL - 82 IS - 7 N2 - BACKGROUND: The prevalence of NTDs in the US declined significantly after mandatory folic acid fortification; however, it is not known if the prevalence of NTDs has continued to decrease in recent years relative to the period immediately following the fortification mandate. METHODS: Population-based data from 21 birth defects surveillance systems were used to examine trends in the birth prevalence of spina bifida and anencephaly during 1999-2000, 2001-2002, and 2003-2004. Prevalence data were stratified by non-Hispanic White, non-Hispanic Black, and Hispanic race or ethnicity. Prevalence ratios were calculated by dividing the birth prevalences during the later time periods (2001-2002 and 2003-2004) by the birth prevalences during 1999-2000. RESULTS: During 1999-2004, 3,311 cases of spina bifida and 2,116 cases of anencephaly were reported. Hispanic infants had the highest prevalences of NTDs for all years. For all infants, the combined birth prevalences of spina bifida and anencephaly decreased 10% from the 1999-2000 period to the 2003-2004 period. The decline in spina bifida (3%) was not significant; however the decline in anencephaly (20%) was statistically significant. CONCLUSIONS: While the prevalences of spina bifida and anencephaly in the United States have declined since folic acid fortification in the food supply began, these data suggest that reductions in the prevalence of anencephaly continued during 2001-2004 and that racial and ethnic and other disparities remain. SN - 1542-0760 UR - https://www.unboundmedicine.com/medline/citation/18481813/Trends_in_the_postfortification_prevalence_of_spina_bifida_and_anencephaly_in_the_United_States_ L2 - https://doi.org/10.1002/bdra.20468 DB - PRIME DP - Unbound Medicine ER -