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Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure.
Addict Biol. 2008 Jun; 13(2):253-63.AB

Abstract

During puberty, neuronal maturation of the brain, which began during perinatal development, is completed such that the behavioral potential of the adult organism can be fully achieved. These maturational events and processes of reorganization are needed for the occurrence of adult behavioral performance but simultaneously render the organism highly susceptible to perturbations, such as exposure to psychoactive drugs, during this critical developmental time span. Considering the variety of maturational processes occurring in the endocannabinoid system during this critical period, it is not surprising that the still-developing brain might by highly susceptible to cannabis exposure. Emerging evidence from human studies and animal research demonstrates that an early onset of cannabis consumption might have lasting consequences on cognition, might increase the risk for neuropsychiatric disorders, promote further illegal drug intake and increase the likelihood of cannabis dependence. These findings suggest that young people represent a highly vulnerable cannabis consumer group and that they run a higher risk than adult consumers of suffering from adverse consequences from cannabinoid exposure. The aim of the present review is to provide an overview over the possible deleterious residual cannabinoid effects during critical periods of postnatal maturation and to offer a more precise delineation of the vulnerable time window for cannabinoid exposure.

Authors+Show Affiliations

Central Institute of Mental Health (ZI), Department of Psychopharmacology, Mannheim, Germany. miriam.schneider@zi-mannheim.de

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18482434

Citation

Schneider, Miriam. "Puberty as a Highly Vulnerable Developmental Period for the Consequences of Cannabis Exposure." Addiction Biology, vol. 13, no. 2, 2008, pp. 253-63.
Schneider M. Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure. Addict Biol. 2008;13(2):253-63.
Schneider, M. (2008). Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure. Addiction Biology, 13(2), 253-63. https://doi.org/10.1111/j.1369-1600.2008.00110.x
Schneider M. Puberty as a Highly Vulnerable Developmental Period for the Consequences of Cannabis Exposure. Addict Biol. 2008;13(2):253-63. PubMed PMID: 18482434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Puberty as a highly vulnerable developmental period for the consequences of cannabis exposure. A1 - Schneider,Miriam, PY - 2008/5/17/pubmed PY - 2008/7/9/medline PY - 2008/5/17/entrez SP - 253 EP - 63 JF - Addiction biology JO - Addict Biol VL - 13 IS - 2 N2 - During puberty, neuronal maturation of the brain, which began during perinatal development, is completed such that the behavioral potential of the adult organism can be fully achieved. These maturational events and processes of reorganization are needed for the occurrence of adult behavioral performance but simultaneously render the organism highly susceptible to perturbations, such as exposure to psychoactive drugs, during this critical developmental time span. Considering the variety of maturational processes occurring in the endocannabinoid system during this critical period, it is not surprising that the still-developing brain might by highly susceptible to cannabis exposure. Emerging evidence from human studies and animal research demonstrates that an early onset of cannabis consumption might have lasting consequences on cognition, might increase the risk for neuropsychiatric disorders, promote further illegal drug intake and increase the likelihood of cannabis dependence. These findings suggest that young people represent a highly vulnerable cannabis consumer group and that they run a higher risk than adult consumers of suffering from adverse consequences from cannabinoid exposure. The aim of the present review is to provide an overview over the possible deleterious residual cannabinoid effects during critical periods of postnatal maturation and to offer a more precise delineation of the vulnerable time window for cannabinoid exposure. SN - 1369-1600 UR - https://www.unboundmedicine.com/medline/citation/18482434/Puberty_as_a_highly_vulnerable_developmental_period_for_the_consequences_of_cannabis_exposure_ L2 - https://doi.org/10.1111/j.1369-1600.2008.00110.x DB - PRIME DP - Unbound Medicine ER -