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Cannabis and psychiatric disorders: it is not only addiction.
Addict Biol. 2008 Jun; 13(2):264-75.AB

Abstract

Since the discovery of the endocannabinoid system, a growing body of psychiatric research has emerged focusing on the role of this system in major psychiatric disorders like schizophrenia (SCZ), bipolar disorder (BD), major depression and anxiety disorder. Continuing in the line of earlier epidemiological studies, recent replication studies indicate that frequent cannabis use doubles the risk for psychotic symptoms and SCZ. Further points of clinical research interest are alterations of endocannabinoids and their relation to symptoms as well as postmortem analyses of cannabinoid CB(1) receptor densities in SCZ. A possible neurobiological mechanism for the deleterious influence of cannabis use in SCZ has been suggested, involving the disruption of endogenous cannabinoid signaling and functioning. Even though the number of studies is still limited for affective and anxiety disorders, previous results suggest these diseases to be exciting objectives of cannabinoid-associated research. Therefore, it became apparent that cannabis use is not only frequent in patients suffering from BD, but that it also induces manic symptoms in this group. In addition, prior antipsychotic treatment decreased the numerical density of CB(1) immunoreactive glial cells in bipolar patients. Although the data on the influence of cannabis use on the development of major depression is controversial, cannabinoid compounds could display a new class of medication, as suggested by the antidepressive effects of the fatty acid amino hydrolase inhibitor URB597 in animal models. With numerous open questions and controversial results, further research is required to specify and extend the findings in this area, which provides a promising target for novel pharmacotherapeutic interventions.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany. leweke@ecnp.netNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18482435

Citation

Leweke, F Markus, and Dagmar Koethe. "Cannabis and Psychiatric Disorders: It Is Not Only Addiction." Addiction Biology, vol. 13, no. 2, 2008, pp. 264-75.
Leweke FM, Koethe D. Cannabis and psychiatric disorders: it is not only addiction. Addict Biol. 2008;13(2):264-75.
Leweke, F. M., & Koethe, D. (2008). Cannabis and psychiatric disorders: it is not only addiction. Addiction Biology, 13(2), 264-75. https://doi.org/10.1111/j.1369-1600.2008.00106.x
Leweke FM, Koethe D. Cannabis and Psychiatric Disorders: It Is Not Only Addiction. Addict Biol. 2008;13(2):264-75. PubMed PMID: 18482435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabis and psychiatric disorders: it is not only addiction. AU - Leweke,F Markus, AU - Koethe,Dagmar, PY - 2008/5/17/pubmed PY - 2008/7/9/medline PY - 2008/5/17/entrez SP - 264 EP - 75 JF - Addiction biology JO - Addict Biol VL - 13 IS - 2 N2 - Since the discovery of the endocannabinoid system, a growing body of psychiatric research has emerged focusing on the role of this system in major psychiatric disorders like schizophrenia (SCZ), bipolar disorder (BD), major depression and anxiety disorder. Continuing in the line of earlier epidemiological studies, recent replication studies indicate that frequent cannabis use doubles the risk for psychotic symptoms and SCZ. Further points of clinical research interest are alterations of endocannabinoids and their relation to symptoms as well as postmortem analyses of cannabinoid CB(1) receptor densities in SCZ. A possible neurobiological mechanism for the deleterious influence of cannabis use in SCZ has been suggested, involving the disruption of endogenous cannabinoid signaling and functioning. Even though the number of studies is still limited for affective and anxiety disorders, previous results suggest these diseases to be exciting objectives of cannabinoid-associated research. Therefore, it became apparent that cannabis use is not only frequent in patients suffering from BD, but that it also induces manic symptoms in this group. In addition, prior antipsychotic treatment decreased the numerical density of CB(1) immunoreactive glial cells in bipolar patients. Although the data on the influence of cannabis use on the development of major depression is controversial, cannabinoid compounds could display a new class of medication, as suggested by the antidepressive effects of the fatty acid amino hydrolase inhibitor URB597 in animal models. With numerous open questions and controversial results, further research is required to specify and extend the findings in this area, which provides a promising target for novel pharmacotherapeutic interventions. SN - 1369-1600 UR - https://www.unboundmedicine.com/medline/citation/18482435/Cannabis_and_psychiatric_disorders:_it_is_not_only_addiction_ L2 - https://doi.org/10.1111/j.1369-1600.2008.00106.x DB - PRIME DP - Unbound Medicine ER -