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Dehydroepiandrosterone prevents age-associated alterations, increasing insulin sensitivity.
J Nutr Biochem 2008; 19(12):809-18JN

Abstract

The age decline in DHEA levels has been associated with the appearance of age-related disorders such as obesity and insulin resistance. The aim of this study was to analyse the effect of chronic administration (13 weeks) of DHEA (5 g/kg diet) to old female rats fed on a high-fat diet on body weight and adiposity, and concretely on the expression of the adipokines related to obesity and insulin resistance, such as leptin, adiponectin and resistin. DHEA treatment induced a decrease in body weight, adipose tissue mass and serum insulin, adiponectin and leptin levels. Adiponectin mRNA expression in visceral fat depots decreased with aging, but this reduction was attenuated by DHEA treatment. DHEA treatment also stimulated resistin gene expression in the ovaric and renal adipose depots, which is associated with an increase in its circulating levels. In conclusion, DHEA treatment decreases body weight and adiposity in old female rats fed a high-fat diet, leading to an improvement of the HOMA index for insulin sensitivity, with decreasing circulating insulin levels, and preventing the age-associated decline of visceral-adipose adiponectin expression.

Authors+Show Affiliations

Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics), University of the Balearic Islands, CIBER Fisiopatología Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III, 07122 Palma de Mallorca, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18482832

Citation

Sánchez, Juana, et al. "Dehydroepiandrosterone Prevents Age-associated Alterations, Increasing Insulin Sensitivity." The Journal of Nutritional Biochemistry, vol. 19, no. 12, 2008, pp. 809-18.
Sánchez J, Pérez-Heredia F, Priego T, et al. Dehydroepiandrosterone prevents age-associated alterations, increasing insulin sensitivity. J Nutr Biochem. 2008;19(12):809-18.
Sánchez, J., Pérez-Heredia, F., Priego, T., Portillo, M. P., Zamora, S., Garaulet, M., & Palou, A. (2008). Dehydroepiandrosterone prevents age-associated alterations, increasing insulin sensitivity. The Journal of Nutritional Biochemistry, 19(12), pp. 809-18. doi:10.1016/j.jnutbio.2007.10.005.
Sánchez J, et al. Dehydroepiandrosterone Prevents Age-associated Alterations, Increasing Insulin Sensitivity. J Nutr Biochem. 2008;19(12):809-18. PubMed PMID: 18482832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dehydroepiandrosterone prevents age-associated alterations, increasing insulin sensitivity. AU - Sánchez,Juana, AU - Pérez-Heredia,Fátima, AU - Priego,Teresa, AU - Portillo,Maria P, AU - Zamora,Salvador, AU - Garaulet,Marta, AU - Palou,Andreu, Y1 - 2008/05/14/ PY - 2007/06/18/received PY - 2007/09/25/revised PY - 2007/10/29/accepted PY - 2008/5/17/pubmed PY - 2009/1/28/medline PY - 2008/5/17/entrez SP - 809 EP - 18 JF - The Journal of nutritional biochemistry JO - J. Nutr. Biochem. VL - 19 IS - 12 N2 - The age decline in DHEA levels has been associated with the appearance of age-related disorders such as obesity and insulin resistance. The aim of this study was to analyse the effect of chronic administration (13 weeks) of DHEA (5 g/kg diet) to old female rats fed on a high-fat diet on body weight and adiposity, and concretely on the expression of the adipokines related to obesity and insulin resistance, such as leptin, adiponectin and resistin. DHEA treatment induced a decrease in body weight, adipose tissue mass and serum insulin, adiponectin and leptin levels. Adiponectin mRNA expression in visceral fat depots decreased with aging, but this reduction was attenuated by DHEA treatment. DHEA treatment also stimulated resistin gene expression in the ovaric and renal adipose depots, which is associated with an increase in its circulating levels. In conclusion, DHEA treatment decreases body weight and adiposity in old female rats fed a high-fat diet, leading to an improvement of the HOMA index for insulin sensitivity, with decreasing circulating insulin levels, and preventing the age-associated decline of visceral-adipose adiponectin expression. SN - 0955-2863 UR - https://www.unboundmedicine.com/medline/citation/18482832/Dehydroepiandrosterone_prevents_age_associated_alterations_increasing_insulin_sensitivity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(07)00259-8 DB - PRIME DP - Unbound Medicine ER -