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Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort.
Int J STD AIDS. 2008 Apr; 19(4):251-8.IJ

Abstract

Drug abuse (addiction) has been listed among the risk factors for human papillomavirus (HPV) infections, but no case-control studies exist to rule out sexual behaviour and other potential confounders. The aim of this study is to evaluate the role of drug addiction as an independent predictor of HR-HPV infections and (cervical intraepithelial neoplasia) CIN2+ in an age-matched case-control (1:4) study nested within the prospective Latin American Screening (LAMS) study cohort. All 109 women in the LAMS cohort (n=12,114) reporting drug abuse/addiction were matched with four controls (n = 436) of non-abusers strictly by age. Conditional logistic regression analysis was used to estimate the co-variates of drug abuse, and the whole series (n=545) was analysed for predictors of HR-HPV and CIN2+ using univariate and multivariate regression models. Oncogenic HPV infections were significantly (P=0.019) more prevalent among abusers (37.7%) than in controls (21.9%), but there was no difference in high-grade squamous intraepithelial lesions (P=0.180) or CIN2+ lesions (P=0.201). In multivariate conditional logistic regression, number of lifetime sexual partners (P=0.0001), ever smokers (P=0.0001), non-use of OCs (P=0.013), ever having sexually transmitted diseases (STD) (P=0.041) and no previous Pap smear (P=0.027) were independent co-variates of drug addiction. Drug abuse was not an independent risk factor of high-risk (HR)-HPV infection, which was significantly predicted by (1) age below 30 years (P=0.045), (2) more than five lifetime sexual partners (P=0.046) and (3) being current smoker (P=0.0001). In multivariate model, only HR-HPV infection was an independent risk factor of CIN2+ (P=0.031), with adjusted OR=11.33 (95% CI 1.25-102.50). These data indicate that drug addiction is not an independent risk factor of either HR-HPV infections or CIN2+, but the increased prevalence of HR-HPV infections is explained by the high-risk sexual behaviour and smoking habits of these women.

Authors+Show Affiliations

Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland. kari.syrjanen@tyks.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18482945

Citation

Syrjänen, K, et al. "Drug Addiction Is Not an Independent Risk Factor for Oncogenic Human Papillomavirus Infections or High-grade Cervical Intraepithelial Neoplasia: Case-control Study Nested Within the Latin American Screening Study Cohort." International Journal of STD & AIDS, vol. 19, no. 4, 2008, pp. 251-8.
Syrjänen K, Naud P, Derchain S, et al. Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort. Int J STD AIDS. 2008;19(4):251-8.
Syrjänen, K., Naud, P., Derchain, S., Roteli-Martins, C., Longatto-Filho, A., Tatti, S., Branca, M., Erzen, M., Hammes, L. S., Matos, J., Gontijo, R., Sarian, L., Bragança, J., Arlindo, F. C., Maeda, M. Y., Lörincz, A., Dores, G. B., Costa, S., & Syrjänen, S. (2008). Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort. International Journal of STD & AIDS, 19(4), 251-8. https://doi.org/10.1258/ijsa.2007.007179
Syrjänen K, et al. Drug Addiction Is Not an Independent Risk Factor for Oncogenic Human Papillomavirus Infections or High-grade Cervical Intraepithelial Neoplasia: Case-control Study Nested Within the Latin American Screening Study Cohort. Int J STD AIDS. 2008;19(4):251-8. PubMed PMID: 18482945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort. AU - Syrjänen,K, AU - Naud,P, AU - Derchain,S, AU - Roteli-Martins,C, AU - Longatto-Filho,A, AU - Tatti,S, AU - Branca,M, AU - Erzen,M, AU - Hammes,L S, AU - Matos,J, AU - Gontijo,R, AU - Sarian,L, AU - Bragança,J, AU - Arlindo,F C, AU - Maeda,M Y S, AU - Lörincz,A, AU - Dores,G B, AU - Costa,S, AU - Syrjänen,S, PY - 2008/5/17/pubmed PY - 2008/8/1/medline PY - 2008/5/17/entrez SP - 251 EP - 8 JF - International journal of STD & AIDS JO - Int J STD AIDS VL - 19 IS - 4 N2 - Drug abuse (addiction) has been listed among the risk factors for human papillomavirus (HPV) infections, but no case-control studies exist to rule out sexual behaviour and other potential confounders. The aim of this study is to evaluate the role of drug addiction as an independent predictor of HR-HPV infections and (cervical intraepithelial neoplasia) CIN2+ in an age-matched case-control (1:4) study nested within the prospective Latin American Screening (LAMS) study cohort. All 109 women in the LAMS cohort (n=12,114) reporting drug abuse/addiction were matched with four controls (n = 436) of non-abusers strictly by age. Conditional logistic regression analysis was used to estimate the co-variates of drug abuse, and the whole series (n=545) was analysed for predictors of HR-HPV and CIN2+ using univariate and multivariate regression models. Oncogenic HPV infections were significantly (P=0.019) more prevalent among abusers (37.7%) than in controls (21.9%), but there was no difference in high-grade squamous intraepithelial lesions (P=0.180) or CIN2+ lesions (P=0.201). In multivariate conditional logistic regression, number of lifetime sexual partners (P=0.0001), ever smokers (P=0.0001), non-use of OCs (P=0.013), ever having sexually transmitted diseases (STD) (P=0.041) and no previous Pap smear (P=0.027) were independent co-variates of drug addiction. Drug abuse was not an independent risk factor of high-risk (HR)-HPV infection, which was significantly predicted by (1) age below 30 years (P=0.045), (2) more than five lifetime sexual partners (P=0.046) and (3) being current smoker (P=0.0001). In multivariate model, only HR-HPV infection was an independent risk factor of CIN2+ (P=0.031), with adjusted OR=11.33 (95% CI 1.25-102.50). These data indicate that drug addiction is not an independent risk factor of either HR-HPV infections or CIN2+, but the increased prevalence of HR-HPV infections is explained by the high-risk sexual behaviour and smoking habits of these women. SN - 0956-4624 UR - https://www.unboundmedicine.com/medline/citation/18482945/Drug_addiction_is_not_an_independent_risk_factor_for_oncogenic_human_papillomavirus_infections_or_high_grade_cervical_intraepithelial_neoplasia:_case_control_study_nested_within_the_Latin_American_Screening_study_cohort_ L2 - http://journals.sagepub.com/doi/full/10.1258/ijsa.2007.007179?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -