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Associations of duration, intensity, and quantity of smoking with adenocarcinoma and squamous cell carcinoma of the esophagus.
Am J Epidemiol. 2008 Jul 01; 168(1):105-14.AJ

Abstract

Smoking has been identified as a risk factor for esophageal cancer; however, there is evidence that magnitudes and patterns of association differ by histologic type. The authors aimed to measure and compare the independent effects of various dimensions of smoking (duration, intensity, total dose, and time since quitting) on risks of esophageal adenocarcinoma (EAC), gastroesophageal junction adenocarcinoma (GEJAC), and esophageal squamous cell carcinoma (ESCC). They used data from a population-based Australian case-control study (2002-2005) comprising 367 EAC cases, 426 GEJAC cases, and 309 ESCC cases and 1,580 controls. Multivariate logistic and generalized additive logistic regression (for nonlinear dose effects) were used. Ever smokers had significantly higher risks of EAC (odds ratio (OR) = 1.7, 95% confidence interval (CI): 1.3, 2.3), GEJAC (OR = 2.4, 95% CI: 1.8, 3.2), and ESCC (OR = 2.8, 95% CI: 2.0, 4.0) than did never smokers; however, there were significant differences in magnitude and patterns of association between subtypes. When multiple dimensions of smoking were assessed concurrently, duration was significantly associated with all three subtypes but intensity was associated only with GEJAC and ESCC, and the associations were nonlinear. For all types of esophageal cancer, time since quitting was independently associated with approximately 15-19% risk reductions per decade.

Authors+Show Affiliations

Population Studies and Human Genetics Division, Queensland Institute of Medical Research, Herston, Queensland, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18483122

Citation

Pandeya, Nirmala, et al. "Associations of Duration, Intensity, and Quantity of Smoking With Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus." American Journal of Epidemiology, vol. 168, no. 1, 2008, pp. 105-14.
Pandeya N, Williams GM, Sadhegi S, et al. Associations of duration, intensity, and quantity of smoking with adenocarcinoma and squamous cell carcinoma of the esophagus. Am J Epidemiol. 2008;168(1):105-14.
Pandeya, N., Williams, G. M., Sadhegi, S., Green, A. C., Webb, P. M., & Whiteman, D. C. (2008). Associations of duration, intensity, and quantity of smoking with adenocarcinoma and squamous cell carcinoma of the esophagus. American Journal of Epidemiology, 168(1), 105-14. https://doi.org/10.1093/aje/kwn091
Pandeya N, et al. Associations of Duration, Intensity, and Quantity of Smoking With Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus. Am J Epidemiol. 2008 Jul 1;168(1):105-14. PubMed PMID: 18483122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of duration, intensity, and quantity of smoking with adenocarcinoma and squamous cell carcinoma of the esophagus. AU - Pandeya,Nirmala, AU - Williams,Gail M, AU - Sadhegi,Shahram, AU - Green,Adèle C, AU - Webb,Penelope M, AU - Whiteman,David C, Y1 - 2008/05/15/ PY - 2008/5/17/pubmed PY - 2008/7/4/medline PY - 2008/5/17/entrez SP - 105 EP - 14 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 168 IS - 1 N2 - Smoking has been identified as a risk factor for esophageal cancer; however, there is evidence that magnitudes and patterns of association differ by histologic type. The authors aimed to measure and compare the independent effects of various dimensions of smoking (duration, intensity, total dose, and time since quitting) on risks of esophageal adenocarcinoma (EAC), gastroesophageal junction adenocarcinoma (GEJAC), and esophageal squamous cell carcinoma (ESCC). They used data from a population-based Australian case-control study (2002-2005) comprising 367 EAC cases, 426 GEJAC cases, and 309 ESCC cases and 1,580 controls. Multivariate logistic and generalized additive logistic regression (for nonlinear dose effects) were used. Ever smokers had significantly higher risks of EAC (odds ratio (OR) = 1.7, 95% confidence interval (CI): 1.3, 2.3), GEJAC (OR = 2.4, 95% CI: 1.8, 3.2), and ESCC (OR = 2.8, 95% CI: 2.0, 4.0) than did never smokers; however, there were significant differences in magnitude and patterns of association between subtypes. When multiple dimensions of smoking were assessed concurrently, duration was significantly associated with all three subtypes but intensity was associated only with GEJAC and ESCC, and the associations were nonlinear. For all types of esophageal cancer, time since quitting was independently associated with approximately 15-19% risk reductions per decade. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/18483122/Associations_of_duration_intensity_and_quantity_of_smoking_with_adenocarcinoma_and_squamous_cell_carcinoma_of_the_esophagus_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwn091 DB - PRIME DP - Unbound Medicine ER -