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Alcohol consumption and the risk for prostate cancer in the European Prospective Investigation into Cancer and Nutrition.

Abstract

Alcohol is a risk factor for several types of cancer. However, the results for prostate cancer have been inconsistent, with most studies showing no association. Within the European Prospective Investigation into Cancer and Nutrition, detailed information were collected from 142,607 male participants on the intake of alcoholic beverages at recruitment (for 100% of the cohort) and over lifetime (for 76% of the cohort) between 1992 and 2000. During a median follow-up of 8.7 years, 2,655 prostate cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of alcohol consumption at recruitment and average lifetime alcohol consumption with prostate cancer adjusted for age, center, smoking, height, weight, physical activity, and nonalcohol energy intake. Overall, neither alcohol consumption at baseline nor average lifetime alcohol consumption was associated with the risk for prostate cancer in this cohort of men. Men who consumed >or=60 g alcohol per day had a relative risk of 0.88 [95% confidence interval (95% CI) 0.72-1.08] compared with men with an intake of 0.1-4.9 g/d; the respective relative risk for average lifetime intake was 1.09 (95% CI, 0.86-1.39). For advanced prostate cancer (n = 537), the relative risks for >or=60 and 0.1-4.9 g alcohol per day at baseline were 0.98 (95% CI, 0.66-1.44) and 1.28 (95% CI, 0.79-2-07), respectively, for average lifetime intake. No statistically significant association was observed for alcohol intake from specific alcoholic beverages. Our results indicate no association between the consumption of alcohol and prostate cancer in this cohort of European men.

Authors+Show Affiliations

Division of Cancer Epidemiology (C020), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. s.rohrmann@dkfz.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18483352

Citation

Rohrmann, Sabine, et al. "Alcohol Consumption and the Risk for Prostate Cancer in the European Prospective Investigation Into Cancer and Nutrition." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 17, no. 5, 2008, pp. 1282-7.
Rohrmann S, Linseisen J, Key TJ, et al. Alcohol consumption and the risk for prostate cancer in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev. 2008;17(5):1282-7.
Rohrmann, S., Linseisen, J., Key, T. J., Jensen, M. K., Overvad, K., Johnsen, N. F., ... Riboli, E. (2008). Alcohol consumption and the risk for prostate cancer in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 17(5), pp. 1282-7. doi:10.1158/1055-9965.EPI-07-2888.
Rohrmann S, et al. Alcohol Consumption and the Risk for Prostate Cancer in the European Prospective Investigation Into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev. 2008;17(5):1282-7. PubMed PMID: 18483352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and the risk for prostate cancer in the European Prospective Investigation into Cancer and Nutrition. AU - Rohrmann,Sabine, AU - Linseisen,Jakob, AU - Key,Timothy J, AU - Jensen,Majken K, AU - Overvad,Kim, AU - Johnsen,Nina Føns, AU - Tjønneland,Anne, AU - Kaaks,Rudolf, AU - Bergmann,Manuela M, AU - Weikert,Cornelia, AU - Naska,Androniki, AU - Trichopoulou,Antonia, AU - Trichopoulos,Dimitrios, AU - Pala,Valeria, AU - Sacerdote,Carlotta, AU - Palli,Domenico, AU - Tumino,Rosario, AU - Bueno-de-Mesquita,H Bas, AU - Vrieling,Alina, AU - González,Carlos A, AU - Larrañaga,Nerea, AU - Navarro,Carmen, AU - Barricarte,Aurelio, AU - Quiros,J Ramon, AU - Martínez-García,Carmen, AU - Hallmans,Göran, AU - Stattin,Pär, AU - Manjer,Jonas, AU - Wirfält,Elisabet, AU - Bingham,Sheila, AU - Khaw,Key-Tee, AU - Egevad,Lars, AU - Ferrari,Pietro, AU - Jenab,Mazda, AU - Riboli,Elio, PY - 2008/5/17/pubmed PY - 2008/10/1/medline PY - 2008/5/17/entrez SP - 1282 EP - 7 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 17 IS - 5 N2 - Alcohol is a risk factor for several types of cancer. However, the results for prostate cancer have been inconsistent, with most studies showing no association. Within the European Prospective Investigation into Cancer and Nutrition, detailed information were collected from 142,607 male participants on the intake of alcoholic beverages at recruitment (for 100% of the cohort) and over lifetime (for 76% of the cohort) between 1992 and 2000. During a median follow-up of 8.7 years, 2,655 prostate cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of alcohol consumption at recruitment and average lifetime alcohol consumption with prostate cancer adjusted for age, center, smoking, height, weight, physical activity, and nonalcohol energy intake. Overall, neither alcohol consumption at baseline nor average lifetime alcohol consumption was associated with the risk for prostate cancer in this cohort of men. Men who consumed >or=60 g alcohol per day had a relative risk of 0.88 [95% confidence interval (95% CI) 0.72-1.08] compared with men with an intake of 0.1-4.9 g/d; the respective relative risk for average lifetime intake was 1.09 (95% CI, 0.86-1.39). For advanced prostate cancer (n = 537), the relative risks for >or=60 and 0.1-4.9 g alcohol per day at baseline were 0.98 (95% CI, 0.66-1.44) and 1.28 (95% CI, 0.79-2-07), respectively, for average lifetime intake. No statistically significant association was observed for alcohol intake from specific alcoholic beverages. Our results indicate no association between the consumption of alcohol and prostate cancer in this cohort of European men. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/18483352/Alcohol_consumption_and_the_risk_for_prostate_cancer_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=18483352 DB - PRIME DP - Unbound Medicine ER -