Tags

Type your tag names separated by a space and hit enter

Urticaria unresponsive to antihistaminic treatment: an open study of therapeutic options based on histopathologic features.
J Dermatolog Treat. 2008; 19(2):92-6.JD

Abstract

BACKGROUND

The non- or low-sedating H1 receptor antagonists represent the basic therapy for urticaria.

OBJECTIVE

To test an alternative approach to patients unresponsive to conventional treatment.

MATERIALS AND METHODS

A total of 22 patients with chronic urticaria unresponsive to conventional antihistamine treatment were enrolled for this study. They had uncontrolled urticaria even using multiple combinations of antihistamines on maximum doses and corticosteroids in short cycles (prednisone 20-40 mg, per os once a day, 3-7 days per month). Cutaneous biopsies of the urticaria lesions were taken. These findings were classified as: (I) a mixture of perivascular dermal inflammatory infiltrate composed of lymphocytes, monocytes and neutrophils and/or eosinophils; (II) inflammatory infiltrate composed chiefly of neutrophils; and (III) inflammatory infiltrate composed mainly of eosinophils. According to histology, the patients were submitted to one of the following therapeutic schemes: class A - antihistamine treatment plus dapsone; class B - colchicine or dapsone; class C - montelukast.

RESULTS

Four patients in class A, 08 in class B and seven in class C displayed complete control of urticaria after 12 weeks of treatment; one patient in class B and two in class C did not respond to treatment. Two years after discontinuation, 16 patients are still free of urticaria.

CONCLUSIONS

This study suggests an alternative approach for treating unresponsive chronic urticaria.

Authors+Show Affiliations

Department of Dermatology, Faculdade de Medicina do ABC Santo Andre, Brazil. rfjcriado@terra.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

18484427

Citation

Criado, Roberta F J., et al. "Urticaria Unresponsive to Antihistaminic Treatment: an Open Study of Therapeutic Options Based On Histopathologic Features." The Journal of Dermatological Treatment, vol. 19, no. 2, 2008, pp. 92-6.
Criado RF, Criado PR, Martins JE, et al. Urticaria unresponsive to antihistaminic treatment: an open study of therapeutic options based on histopathologic features. J Dermatolog Treat. 2008;19(2):92-6.
Criado, R. F., Criado, P. R., Martins, J. E., Valente, N. Y., Michalany, N. S., & Vasconcellos, C. (2008). Urticaria unresponsive to antihistaminic treatment: an open study of therapeutic options based on histopathologic features. The Journal of Dermatological Treatment, 19(2), 92-6. https://doi.org/10.1080/09546630701499309
Criado RF, et al. Urticaria Unresponsive to Antihistaminic Treatment: an Open Study of Therapeutic Options Based On Histopathologic Features. J Dermatolog Treat. 2008;19(2):92-6. PubMed PMID: 18484427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urticaria unresponsive to antihistaminic treatment: an open study of therapeutic options based on histopathologic features. AU - Criado,Roberta F J, AU - Criado,Paulo Ricardo, AU - Martins,Jose Eduardo C, AU - Valente,Neusa Y S, AU - Michalany,Nilceo S, AU - Vasconcellos,Cidia, PY - 2008/5/20/pubmed PY - 2008/7/11/medline PY - 2008/5/20/entrez SP - 92 EP - 6 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 19 IS - 2 N2 - BACKGROUND: The non- or low-sedating H1 receptor antagonists represent the basic therapy for urticaria. OBJECTIVE: To test an alternative approach to patients unresponsive to conventional treatment. MATERIALS AND METHODS: A total of 22 patients with chronic urticaria unresponsive to conventional antihistamine treatment were enrolled for this study. They had uncontrolled urticaria even using multiple combinations of antihistamines on maximum doses and corticosteroids in short cycles (prednisone 20-40 mg, per os once a day, 3-7 days per month). Cutaneous biopsies of the urticaria lesions were taken. These findings were classified as: (I) a mixture of perivascular dermal inflammatory infiltrate composed of lymphocytes, monocytes and neutrophils and/or eosinophils; (II) inflammatory infiltrate composed chiefly of neutrophils; and (III) inflammatory infiltrate composed mainly of eosinophils. According to histology, the patients were submitted to one of the following therapeutic schemes: class A - antihistamine treatment plus dapsone; class B - colchicine or dapsone; class C - montelukast. RESULTS: Four patients in class A, 08 in class B and seven in class C displayed complete control of urticaria after 12 weeks of treatment; one patient in class B and two in class C did not respond to treatment. Two years after discontinuation, 16 patients are still free of urticaria. CONCLUSIONS: This study suggests an alternative approach for treating unresponsive chronic urticaria. SN - 0954-6634 UR - https://www.unboundmedicine.com/medline/citation/18484427/Urticaria_unresponsive_to_antihistaminic_treatment:_an_open_study_of_therapeutic_options_based_on_histopathologic_features_ L2 - https://www.tandfonline.com/doi/full/10.1080/09546630701499309 DB - PRIME DP - Unbound Medicine ER -