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Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts.
Inflamm Bowel Dis. 2008 Oct; 14(10):1348-57.IB

Abstract

BACKGROUND

Although the immunoregulatory effects of omega-3 fatty acid and adiponectin have been postulated, their role in intestinal inflammation is controversial. The aim of this study was to determine whether dietary fat intake influences activity of colonic inflammation through modulating this system.

METHODS

C57BL/6 mice received dextran sulfate sodium for induction of colitis. Mice were fed a control diet, omega-3 fat-rich diet, omega-6 fat-rich diet, or saturated fat-rich diet. Some mice were administered a peroxisome proliferator activated receptor-gamma; agonist, pioglitazone. Messenger RNA expression of adiponectin and its receptors were analyzed. Adiponectin expression in colonic mucosa of ulcerative colitis patients was also analyzed.

RESULTS

The receptors for adiponectin were found to be ubiquitously expressed in epithelial cells, intraepithelial lymphocytes, lamina proprial mononuclear cells, and subepithelial myofibroblasts from colonic tissue, but adiponectin was only expressed in myofibroblasts. Induction of colitis significantly decreased the expression of adiponectin in colonic mucosa. The omega-3 fat diet group, but not the other fat diet groups, showed exacerbated colitis with a further decrease of adiponectin expression. Pioglitazone treatment ameliorated the level of decrease in adiponectin expression and improved colonic inflammation induced by the omega-3 fat-rich diet. In patients with ulcerative colitis, the expression level of adiponectin in colonic mucosa was also decreased compared with that in control mucosa.

CONCLUSIONS

Adiponectin was found to be expressed in myofibroblasts. Adiponectin expression was significantly suppressed by induction of colitis, and aggravation of colitis after exposure to omega-3 fat may be due to a further decrease in the expression level of adiponectin.

Authors+Show Affiliations

Department of Internal Medicine, National Defense Medical College, Saitama, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18484673

Citation

Matsunaga, Hisayuki, et al. "Omega-3 Fatty Acids Exacerbate DSS-induced Colitis Through Decreased Adiponectin in Colonic Subepithelial Myofibroblasts." Inflammatory Bowel Diseases, vol. 14, no. 10, 2008, pp. 1348-57.
Matsunaga H, Hokari R, Kurihara C, et al. Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts. Inflamm Bowel Dis. 2008;14(10):1348-57.
Matsunaga, H., Hokari, R., Kurihara, C., Okada, Y., Takebayashi, K., Okudaira, K., Watanabe, C., Komoto, S., Nakamura, M., Tsuzuki, Y., Kawaguchi, A., Nagao, S., Itoh, K., & Miura, S. (2008). Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts. Inflammatory Bowel Diseases, 14(10), 1348-57. https://doi.org/10.1002/ibd.20491
Matsunaga H, et al. Omega-3 Fatty Acids Exacerbate DSS-induced Colitis Through Decreased Adiponectin in Colonic Subepithelial Myofibroblasts. Inflamm Bowel Dis. 2008;14(10):1348-57. PubMed PMID: 18484673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts. AU - Matsunaga,Hisayuki, AU - Hokari,Ryota, AU - Kurihara,Chie, AU - Okada,Yoshikiyo, AU - Takebayashi,Koichi, AU - Okudaira,Keisuke, AU - Watanabe,Chikako, AU - Komoto,Syunsuke, AU - Nakamura,Mitsuyasu, AU - Tsuzuki,Yoshikazu, AU - Kawaguchi,Atushi, AU - Nagao,Shigeaki, AU - Itoh,Kazuro, AU - Miura,Soichiro, PY - 2008/5/20/pubmed PY - 2009/2/12/medline PY - 2008/5/20/entrez SP - 1348 EP - 57 JF - Inflammatory bowel diseases JO - Inflamm. Bowel Dis. VL - 14 IS - 10 N2 - BACKGROUND: Although the immunoregulatory effects of omega-3 fatty acid and adiponectin have been postulated, their role in intestinal inflammation is controversial. The aim of this study was to determine whether dietary fat intake influences activity of colonic inflammation through modulating this system. METHODS: C57BL/6 mice received dextran sulfate sodium for induction of colitis. Mice were fed a control diet, omega-3 fat-rich diet, omega-6 fat-rich diet, or saturated fat-rich diet. Some mice were administered a peroxisome proliferator activated receptor-gamma; agonist, pioglitazone. Messenger RNA expression of adiponectin and its receptors were analyzed. Adiponectin expression in colonic mucosa of ulcerative colitis patients was also analyzed. RESULTS: The receptors for adiponectin were found to be ubiquitously expressed in epithelial cells, intraepithelial lymphocytes, lamina proprial mononuclear cells, and subepithelial myofibroblasts from colonic tissue, but adiponectin was only expressed in myofibroblasts. Induction of colitis significantly decreased the expression of adiponectin in colonic mucosa. The omega-3 fat diet group, but not the other fat diet groups, showed exacerbated colitis with a further decrease of adiponectin expression. Pioglitazone treatment ameliorated the level of decrease in adiponectin expression and improved colonic inflammation induced by the omega-3 fat-rich diet. In patients with ulcerative colitis, the expression level of adiponectin in colonic mucosa was also decreased compared with that in control mucosa. CONCLUSIONS: Adiponectin was found to be expressed in myofibroblasts. Adiponectin expression was significantly suppressed by induction of colitis, and aggravation of colitis after exposure to omega-3 fat may be due to a further decrease in the expression level of adiponectin. SN - 1536-4844 UR - https://www.unboundmedicine.com/medline/citation/18484673/Omega_3_fatty_acids_exacerbate_DSS_induced_colitis_through_decreased_adiponectin_in_colonic_subepithelial_myofibroblasts_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=18484673.ui DB - PRIME DP - Unbound Medicine ER -