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Risk-reducing effect of education in Alzheimer's disease.
Int J Geriatr Psychiatry. 2008 Nov; 23(11):1156-62.IJ

Abstract

OBJECTIVE

To estimate the effect of education on the risk of Alzheimer's disease (AD).

METHODS

373 patients diagnosed with AD and 559 healthy control individuals without first degree relatives with known dementia, were included in a case-control study (2003-2006). All individuals were genotyped for APOE alleles. Odds ratio (OR) for developing AD was calculated by binary logistic regression, with the number of APOE epsilon 4 alleles and educational level as covariates. Analyses were carried out separately for men and women and for different age groups.

RESULTS

Carriers of one APOE epsilon 4 allele had OR of 4.2, and carriers of two APOE epsilon 4 alleles OR of 12.4 for developing AD. When adjusted for the number of APOE epsilon 4 alleles, OR for developing AD was significantly reduced in participants with 8-9 years of education compared to those with only 6-7 years, and was reduced further for those with 10-18 years of education. These findings were obtained for all the age groups studied and for both men and women.

CONCLUSIONS

Education had a consistently protective effect on the risk of developing clinical AD in a dose-dependent manner in both men and women, and in all age groups, also when adjusting for the number of APOE epsilon 4 alleles. Male gender was protective, probably at least in part because of a higher educational level.

Authors+Show Affiliations

Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. sigrid.b.sando@ntnu.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18484674

Citation

Sando, Sigrid Botne, et al. "Risk-reducing Effect of Education in Alzheimer's Disease." International Journal of Geriatric Psychiatry, vol. 23, no. 11, 2008, pp. 1156-62.
Sando SB, Melquist S, Cannon A, et al. Risk-reducing effect of education in Alzheimer's disease. Int J Geriatr Psychiatry. 2008;23(11):1156-62.
Sando, S. B., Melquist, S., Cannon, A., Hutton, M., Sletvold, O., Saltvedt, I., White, L. R., Lydersen, S., & Aasly, J. (2008). Risk-reducing effect of education in Alzheimer's disease. International Journal of Geriatric Psychiatry, 23(11), 1156-62. https://doi.org/10.1002/gps.2043
Sando SB, et al. Risk-reducing Effect of Education in Alzheimer's Disease. Int J Geriatr Psychiatry. 2008;23(11):1156-62. PubMed PMID: 18484674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk-reducing effect of education in Alzheimer's disease. AU - Sando,Sigrid Botne, AU - Melquist,Stacey, AU - Cannon,Ashley, AU - Hutton,Michael, AU - Sletvold,Olav, AU - Saltvedt,Ingvild, AU - White,Linda R, AU - Lydersen,Stian, AU - Aasly,Jan, PY - 2008/5/20/pubmed PY - 2009/5/22/medline PY - 2008/5/20/entrez SP - 1156 EP - 62 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 23 IS - 11 N2 - OBJECTIVE: To estimate the effect of education on the risk of Alzheimer's disease (AD). METHODS: 373 patients diagnosed with AD and 559 healthy control individuals without first degree relatives with known dementia, were included in a case-control study (2003-2006). All individuals were genotyped for APOE alleles. Odds ratio (OR) for developing AD was calculated by binary logistic regression, with the number of APOE epsilon 4 alleles and educational level as covariates. Analyses were carried out separately for men and women and for different age groups. RESULTS: Carriers of one APOE epsilon 4 allele had OR of 4.2, and carriers of two APOE epsilon 4 alleles OR of 12.4 for developing AD. When adjusted for the number of APOE epsilon 4 alleles, OR for developing AD was significantly reduced in participants with 8-9 years of education compared to those with only 6-7 years, and was reduced further for those with 10-18 years of education. These findings were obtained for all the age groups studied and for both men and women. CONCLUSIONS: Education had a consistently protective effect on the risk of developing clinical AD in a dose-dependent manner in both men and women, and in all age groups, also when adjusting for the number of APOE epsilon 4 alleles. Male gender was protective, probably at least in part because of a higher educational level. SN - 1099-1166 UR - https://www.unboundmedicine.com/medline/citation/18484674/Risk_reducing_effect_of_education_in_Alzheimer's_disease_ L2 - https://doi.org/10.1002/gps.2043 DB - PRIME DP - Unbound Medicine ER -