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Epigallocatechin gallate improves serum lipid profile and erythrocyte and cardiac tissue antioxidant parameters in Wistar rats fed an atherogenic diet.
Fundam Clin Pharmacol. 2008 Jun; 22(3):275-84.FC

Abstract

Oxidative stress is believed to contribute to the pathogenesis of hypercholesterolaemic atherosclerosis; hence, various antioxidant compounds are being evaluated for potential anti-atherogenic effects. The present study assessed the efficacy of epigallocatechin gallate (EGCG), an antioxidant component of the plant Camellia sinensis, in improving serum lipid profile and antioxidant parameters in erythrocytes and cardiac tissue in rats fed an atherogenic diet. In male albino Wistar rats fed an atherogenic diet for 30 days, significantly increased serum levels of total cholesterol, triglycerides and lipoprotein cholesterol fractions and cardiac risk ratio were noted, compared with levels in rats fed a normal diet. Intraperitoneal administration of EGCG (100 mg/kg) for 7 or 15 days to the atherogenic diet-fed rats resulted in significantly lower serum levels of total cholesterol, triglycerides, low-density and very low density lipoprotein cholesterol fractions and a significantly higher serum level of high-density lipoprotein cholesterol compared with levels in atherogenic diet-fed, saline-treated rats. Significantly higher mean malondialdehyde levels and significantly lower mean activities of antioxidant enzymes and mean levels of non-enzymatic antioxidants occurred in atherogenic diet-fed rats compared with those fed a normal diet. When atherogenic diet-fed rats received EGCG treatment for 7 or 15 days, significantly lower mean levels of MDA, higher mean levels of non-enzymatic antioxidants and higher mean activities of enzymatic antioxidants occurred, compared with those in saline-treated rats. Thus, EGCG appears to ameliorate disruptions of serum lipid profile and of antioxidant parameters in erythrocyte and cardiac tissue of Wistar rats fed an atherogenic diet; these results may be relevant to treating human atherosclerosis.

Authors+Show Affiliations

Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18485145

Citation

Ramesh, E, et al. "Epigallocatechin Gallate Improves Serum Lipid Profile and Erythrocyte and Cardiac Tissue Antioxidant Parameters in Wistar Rats Fed an Atherogenic Diet." Fundamental & Clinical Pharmacology, vol. 22, no. 3, 2008, pp. 275-84.
Ramesh E, Elanchezhian R, Sakthivel M, et al. Epigallocatechin gallate improves serum lipid profile and erythrocyte and cardiac tissue antioxidant parameters in Wistar rats fed an atherogenic diet. Fundam Clin Pharmacol. 2008;22(3):275-84.
Ramesh, E., Elanchezhian, R., Sakthivel, M., Jayakumar, T., Senthil Kumar, R. S., Geraldine, P., & Thomas, P. A. (2008). Epigallocatechin gallate improves serum lipid profile and erythrocyte and cardiac tissue antioxidant parameters in Wistar rats fed an atherogenic diet. Fundamental & Clinical Pharmacology, 22(3), 275-84. https://doi.org/10.1111/j.1472-8206.2008.00585.x
Ramesh E, et al. Epigallocatechin Gallate Improves Serum Lipid Profile and Erythrocyte and Cardiac Tissue Antioxidant Parameters in Wistar Rats Fed an Atherogenic Diet. Fundam Clin Pharmacol. 2008;22(3):275-84. PubMed PMID: 18485145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epigallocatechin gallate improves serum lipid profile and erythrocyte and cardiac tissue antioxidant parameters in Wistar rats fed an atherogenic diet. AU - Ramesh,E, AU - Elanchezhian,R, AU - Sakthivel,M, AU - Jayakumar,T, AU - Senthil Kumar,R S, AU - Geraldine,P, AU - Thomas,P A, PY - 2008/5/20/pubmed PY - 2008/6/13/medline PY - 2008/5/20/entrez SP - 275 EP - 84 JF - Fundamental & clinical pharmacology JO - Fundam Clin Pharmacol VL - 22 IS - 3 N2 - Oxidative stress is believed to contribute to the pathogenesis of hypercholesterolaemic atherosclerosis; hence, various antioxidant compounds are being evaluated for potential anti-atherogenic effects. The present study assessed the efficacy of epigallocatechin gallate (EGCG), an antioxidant component of the plant Camellia sinensis, in improving serum lipid profile and antioxidant parameters in erythrocytes and cardiac tissue in rats fed an atherogenic diet. In male albino Wistar rats fed an atherogenic diet for 30 days, significantly increased serum levels of total cholesterol, triglycerides and lipoprotein cholesterol fractions and cardiac risk ratio were noted, compared with levels in rats fed a normal diet. Intraperitoneal administration of EGCG (100 mg/kg) for 7 or 15 days to the atherogenic diet-fed rats resulted in significantly lower serum levels of total cholesterol, triglycerides, low-density and very low density lipoprotein cholesterol fractions and a significantly higher serum level of high-density lipoprotein cholesterol compared with levels in atherogenic diet-fed, saline-treated rats. Significantly higher mean malondialdehyde levels and significantly lower mean activities of antioxidant enzymes and mean levels of non-enzymatic antioxidants occurred in atherogenic diet-fed rats compared with those fed a normal diet. When atherogenic diet-fed rats received EGCG treatment for 7 or 15 days, significantly lower mean levels of MDA, higher mean levels of non-enzymatic antioxidants and higher mean activities of enzymatic antioxidants occurred, compared with those in saline-treated rats. Thus, EGCG appears to ameliorate disruptions of serum lipid profile and of antioxidant parameters in erythrocyte and cardiac tissue of Wistar rats fed an atherogenic diet; these results may be relevant to treating human atherosclerosis. SN - 1472-8206 UR - https://www.unboundmedicine.com/medline/citation/18485145/Epigallocatechin_gallate_improves_serum_lipid_profile_and_erythrocyte_and_cardiac_tissue_antioxidant_parameters_in_Wistar_rats_fed_an_atherogenic_diet_ L2 - https://doi.org/10.1111/j.1472-8206.2008.00585.x DB - PRIME DP - Unbound Medicine ER -