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Quality of life in bipolar type I disorder and schizophrenia in remission: clinical and neurocognitive correlates.
Psychiatry Res. 2008 Jul 15; 160(1):55-62.PR

Abstract

This cross-sectional study examined the relationships between clinical and neuropsychological variables and self-reported quality of life (QoL) in 30 euthymic bipolar I patients, 23 remitted schizophrenic patients, and 23 healthy controls. Participants were administered the World Health Organization Quality of Life Measure-Abbreviated Version (WHOQOL-BREF) to assess QoL. Moreover, a broad neuropsychological battery was also administered. Bipolar disorder (BD) and schizophrenia patients demonstrated significantly lower scores on the physical, psychological, and social domains of the WHOQOL-BREF compared with controls, but there were no significant differences between the two patient groups on those domains. More symptomatic BD patients reported worse QoL, especially in the physical and environmental domains, which was also associated with worse neurocognitive performance. In schizophrenic patients, neurocognitive performance was not associated with self-reported QoL, but more symptomatic patients reported lower QoL. Substantial impairments in QoL, similar in severity, were found in both patient groups. In patients with schizophrenia, QoL was more strongly related to levels of psychopathology, whereas in BD patients, both psychopathology and neurocognitive deficits were strongly associated with lower QoL. Clinical recovery is essential in schizophrenia and BD. The association between cognitive functioning and QoL in bipolar patients suggests that these patients may also benefit from psychological interventions addressed to improve cognitive deficits and enhance the functional recovery.

Authors+Show Affiliations

Júlio de Matos' Psychiatric Hospital, Lisbon, Portugal. sofiabrissos@netcabo.ptNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18485488

Citation

Brissos, Sofia, et al. "Quality of Life in Bipolar Type I Disorder and Schizophrenia in Remission: Clinical and Neurocognitive Correlates." Psychiatry Research, vol. 160, no. 1, 2008, pp. 55-62.
Brissos S, Dias VV, Carita AI, et al. Quality of life in bipolar type I disorder and schizophrenia in remission: clinical and neurocognitive correlates. Psychiatry Res. 2008;160(1):55-62.
Brissos, S., Dias, V. V., Carita, A. I., & Martinez-Arán, A. (2008). Quality of life in bipolar type I disorder and schizophrenia in remission: clinical and neurocognitive correlates. Psychiatry Research, 160(1), 55-62. https://doi.org/10.1016/j.psychres.2007.04.010
Brissos S, et al. Quality of Life in Bipolar Type I Disorder and Schizophrenia in Remission: Clinical and Neurocognitive Correlates. Psychiatry Res. 2008 Jul 15;160(1):55-62. PubMed PMID: 18485488.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quality of life in bipolar type I disorder and schizophrenia in remission: clinical and neurocognitive correlates. AU - Brissos,Sofia, AU - Dias,Vasco Videira, AU - Carita,Ana Isabel, AU - Martinez-Arán,Anabel, Y1 - 2008/05/15/ PY - 2006/07/09/received PY - 2006/11/15/revised PY - 2007/04/07/accepted PY - 2008/5/20/pubmed PY - 2008/10/9/medline PY - 2008/5/20/entrez SP - 55 EP - 62 JF - Psychiatry research JO - Psychiatry Res VL - 160 IS - 1 N2 - This cross-sectional study examined the relationships between clinical and neuropsychological variables and self-reported quality of life (QoL) in 30 euthymic bipolar I patients, 23 remitted schizophrenic patients, and 23 healthy controls. Participants were administered the World Health Organization Quality of Life Measure-Abbreviated Version (WHOQOL-BREF) to assess QoL. Moreover, a broad neuropsychological battery was also administered. Bipolar disorder (BD) and schizophrenia patients demonstrated significantly lower scores on the physical, psychological, and social domains of the WHOQOL-BREF compared with controls, but there were no significant differences between the two patient groups on those domains. More symptomatic BD patients reported worse QoL, especially in the physical and environmental domains, which was also associated with worse neurocognitive performance. In schizophrenic patients, neurocognitive performance was not associated with self-reported QoL, but more symptomatic patients reported lower QoL. Substantial impairments in QoL, similar in severity, were found in both patient groups. In patients with schizophrenia, QoL was more strongly related to levels of psychopathology, whereas in BD patients, both psychopathology and neurocognitive deficits were strongly associated with lower QoL. Clinical recovery is essential in schizophrenia and BD. The association between cognitive functioning and QoL in bipolar patients suggests that these patients may also benefit from psychological interventions addressed to improve cognitive deficits and enhance the functional recovery. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/18485488/Quality_of_life_in_bipolar_type_I_disorder_and_schizophrenia_in_remission:_clinical_and_neurocognitive_correlates_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(07)00121-7 DB - PRIME DP - Unbound Medicine ER -