Tags

Type your tag names separated by a space and hit enter

Risks for type-2 diabetes associated with the metabolic syndrome and the interaction between impaired fasting glucose and other components of metabolic syndrome the study from Jiangsu, China of 5 years follow-up.
Diabetes Res Clin Pract. 2008 Jul; 81(1):117-23.DR

Abstract

AIMS

The aim of this study was to determine whether the metabolic syndrome (MS) preceded incidence of type-2 diabetes (T2DM) by 5 years and to investigate the interaction between impaired fasting glucose (IFG) and other components of MS.

METHODS

Subjects were recruited from the cohort study on the prevention of multiple metabolic disorders and MS in Jiangsu province, China; at the 5 years follow-up period (N=1844). The National Cholesterol Education Program Adult Treatment Panel III Asian criterion was used to define MS. In present study, we compared the T2DM risk among individuals with or without MS at baseline. Also the interaction between the IFG and other components of MS were evaluated.

RESULTS

Subjects with MS had a 2.3 (1.5-3.6) adjusted relative risk (aRR) of developing T2DM when compared with individuals without non-MS at baseline. Incidentally, the aRRs of MS components were 5.4 (2.6-10.8) for IFG, 2.6 (1.2-5.9) for greater waist circumference, 3.5 (1.6-7.4) for elevated triglyceride, 4.7 (2.3-9.9) for elevated blood pressure, and 2.4 (1.1-5.3) for low high density lipoprotein. After further adjustment of the components of MS, only IFG was found to be statistically significant. The T2DM risk of individuals combined with IFG increased by the number of other MS components. The result of interaction analysis was SI=1.41 but without significance.

CONCLUSIONS

Subjects with MS were at a higher risk of developing T2DM than those who did not have the syndrome. Also IFG was found to be an excellent predictor of T2DM. However, there was not a significant interaction between IFG and the other MS components.

Authors+Show Affiliations

Department of Radiology & Public Health, Soochow University, SuZhou 215123, JiangSu, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18485514

Citation

Liu, Shi-Jun, et al. "Risks for Type-2 Diabetes Associated With the Metabolic Syndrome and the Interaction Between Impaired Fasting Glucose and Other Components of Metabolic Syndrome the Study From Jiangsu, China of 5 Years Follow-up." Diabetes Research and Clinical Practice, vol. 81, no. 1, 2008, pp. 117-23.
Liu SJ, Guo ZR, Hu XS, et al. Risks for type-2 diabetes associated with the metabolic syndrome and the interaction between impaired fasting glucose and other components of metabolic syndrome the study from Jiangsu, China of 5 years follow-up. Diabetes Res Clin Pract. 2008;81(1):117-23.
Liu, S. J., Guo, Z. R., Hu, X. S., Wu, M., Chen, F. M., Kang, G. D., Zhou, H., & Guo, L. (2008). Risks for type-2 diabetes associated with the metabolic syndrome and the interaction between impaired fasting glucose and other components of metabolic syndrome the study from Jiangsu, China of 5 years follow-up. Diabetes Research and Clinical Practice, 81(1), 117-23. https://doi.org/10.1016/j.diabres.2008.03.008
Liu SJ, et al. Risks for Type-2 Diabetes Associated With the Metabolic Syndrome and the Interaction Between Impaired Fasting Glucose and Other Components of Metabolic Syndrome the Study From Jiangsu, China of 5 Years Follow-up. Diabetes Res Clin Pract. 2008;81(1):117-23. PubMed PMID: 18485514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risks for type-2 diabetes associated with the metabolic syndrome and the interaction between impaired fasting glucose and other components of metabolic syndrome the study from Jiangsu, China of 5 years follow-up. AU - Liu,Shi-Jun, AU - Guo,Zhi-Rong, AU - Hu,Xiao-Shu, AU - Wu,Ming, AU - Chen,Feng-Mei, AU - Kang,Guo-Dong, AU - Zhou,Hui, AU - Guo,Lu, Y1 - 2008/05/15/ PY - 2008/02/07/received PY - 2008/03/11/accepted PY - 2008/5/20/pubmed PY - 2008/8/7/medline PY - 2008/5/20/entrez SP - 117 EP - 23 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 81 IS - 1 N2 - AIMS: The aim of this study was to determine whether the metabolic syndrome (MS) preceded incidence of type-2 diabetes (T2DM) by 5 years and to investigate the interaction between impaired fasting glucose (IFG) and other components of MS. METHODS: Subjects were recruited from the cohort study on the prevention of multiple metabolic disorders and MS in Jiangsu province, China; at the 5 years follow-up period (N=1844). The National Cholesterol Education Program Adult Treatment Panel III Asian criterion was used to define MS. In present study, we compared the T2DM risk among individuals with or without MS at baseline. Also the interaction between the IFG and other components of MS were evaluated. RESULTS: Subjects with MS had a 2.3 (1.5-3.6) adjusted relative risk (aRR) of developing T2DM when compared with individuals without non-MS at baseline. Incidentally, the aRRs of MS components were 5.4 (2.6-10.8) for IFG, 2.6 (1.2-5.9) for greater waist circumference, 3.5 (1.6-7.4) for elevated triglyceride, 4.7 (2.3-9.9) for elevated blood pressure, and 2.4 (1.1-5.3) for low high density lipoprotein. After further adjustment of the components of MS, only IFG was found to be statistically significant. The T2DM risk of individuals combined with IFG increased by the number of other MS components. The result of interaction analysis was SI=1.41 but without significance. CONCLUSIONS: Subjects with MS were at a higher risk of developing T2DM than those who did not have the syndrome. Also IFG was found to be an excellent predictor of T2DM. However, there was not a significant interaction between IFG and the other MS components. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/18485514/Risks_for_type_2_diabetes_associated_with_the_metabolic_syndrome_and_the_interaction_between_impaired_fasting_glucose_and_other_components_of_metabolic_syndrome_the_study_from_Jiangsu_China_of_5_years_follow_up_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(08)00114-9 DB - PRIME DP - Unbound Medicine ER -