Tags

Type your tag names separated by a space and hit enter

Morphine and methadone pre-exposures differently modify brain regional Fos protein expression and locomotor activity responses to morphine challenge in the rat.
Drug Alcohol Depend. 2008 Sep 01; 97(1-2):21-32.DA

Abstract

Methadone is commonly used in substitution therapy of heroin addicts; hence, its potential for modifying reactions to opiates is of clinical importance. We compared the effects of repeated daily and every-other-day pre-exposure of rats to s.c. morphine and methadone on locomotor activity and CNS neuronal activation (as assessed by Fos immunohistochemistry) responses to s.c. morphine challenge given 2 weeks after the completion of the pretreatment. The challenge revealed behavioral sensitization after daily morphine pretreatment only. Dorsomedial striatum and basolateral amygdaloid nucleus showed robust morphine-induced Fos protein induction that was unaffected by the pretreatments tested. Centrolateral striatum, shell and core of the nucleus accumbens, paraventricular thalamic nucleus and some layers of motor and somatosensory cortices showed but negligible Fos protein induction in drug-naive rats; this response was markedly enhanced by morphine pretreatment only, which effect might be related to the emergence of opiate addiction. Minor Fos responses to morphine were also found in layers IV and VI of the somatosensory cortex and layer VI of the insular cortex of the drug-naïve rats; these responses were significantly enhanced both by morphine and methadone pretreatment. The similarity of methadone and morphine pretreatments' effects in the latter cortical regions might be relevant to the ability of methadone to alleviate signs of abstinence syndrome and craving in heroin addicts. In summary, this study revealed differing and relatively long-lasting effects of prolonged administration of morphine and methadone on the profile of behavioral and CNS neuronal activation responses to morphine challenge in the rat.

Authors+Show Affiliations

Department of Neurochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland. taracha@ipin.edu.pl <taracha@ipin.edu.pl>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18485622

Citation

Taracha, Ewa, et al. "Morphine and Methadone Pre-exposures Differently Modify Brain Regional Fos Protein Expression and Locomotor Activity Responses to Morphine Challenge in the Rat." Drug and Alcohol Dependence, vol. 97, no. 1-2, 2008, pp. 21-32.
Taracha E, Chrapusta SJ, Lehner M, et al. Morphine and methadone pre-exposures differently modify brain regional Fos protein expression and locomotor activity responses to morphine challenge in the rat. Drug Alcohol Depend. 2008;97(1-2):21-32.
Taracha, E., Chrapusta, S. J., Lehner, M., Skórzewska, A., Maciejak, P., Szyndler, J., & Płaźnik, A. (2008). Morphine and methadone pre-exposures differently modify brain regional Fos protein expression and locomotor activity responses to morphine challenge in the rat. Drug and Alcohol Dependence, 97(1-2), 21-32. https://doi.org/10.1016/j.drugalcdep.2008.03.013
Taracha E, et al. Morphine and Methadone Pre-exposures Differently Modify Brain Regional Fos Protein Expression and Locomotor Activity Responses to Morphine Challenge in the Rat. Drug Alcohol Depend. 2008 Sep 1;97(1-2):21-32. PubMed PMID: 18485622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphine and methadone pre-exposures differently modify brain regional Fos protein expression and locomotor activity responses to morphine challenge in the rat. AU - Taracha,Ewa, AU - Chrapusta,Stanisław J, AU - Lehner,Małgorzata, AU - Skórzewska,Anna, AU - Maciejak,Piotr, AU - Szyndler,Janusz, AU - Płaźnik,Adam, Y1 - 2008/05/15/ PY - 2007/11/04/received PY - 2008/03/05/revised PY - 2008/03/08/accepted PY - 2008/5/20/pubmed PY - 2008/12/17/medline PY - 2008/5/20/entrez SP - 21 EP - 32 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 97 IS - 1-2 N2 - Methadone is commonly used in substitution therapy of heroin addicts; hence, its potential for modifying reactions to opiates is of clinical importance. We compared the effects of repeated daily and every-other-day pre-exposure of rats to s.c. morphine and methadone on locomotor activity and CNS neuronal activation (as assessed by Fos immunohistochemistry) responses to s.c. morphine challenge given 2 weeks after the completion of the pretreatment. The challenge revealed behavioral sensitization after daily morphine pretreatment only. Dorsomedial striatum and basolateral amygdaloid nucleus showed robust morphine-induced Fos protein induction that was unaffected by the pretreatments tested. Centrolateral striatum, shell and core of the nucleus accumbens, paraventricular thalamic nucleus and some layers of motor and somatosensory cortices showed but negligible Fos protein induction in drug-naive rats; this response was markedly enhanced by morphine pretreatment only, which effect might be related to the emergence of opiate addiction. Minor Fos responses to morphine were also found in layers IV and VI of the somatosensory cortex and layer VI of the insular cortex of the drug-naïve rats; these responses were significantly enhanced both by morphine and methadone pretreatment. The similarity of methadone and morphine pretreatments' effects in the latter cortical regions might be relevant to the ability of methadone to alleviate signs of abstinence syndrome and craving in heroin addicts. In summary, this study revealed differing and relatively long-lasting effects of prolonged administration of morphine and methadone on the profile of behavioral and CNS neuronal activation responses to morphine challenge in the rat. SN - 0376-8716 UR - https://www.unboundmedicine.com/medline/citation/18485622/Morphine_and_methadone_pre_exposures_differently_modify_brain_regional_Fos_protein_expression_and_locomotor_activity_responses_to_morphine_challenge_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(08)00107-5 DB - PRIME DP - Unbound Medicine ER -