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Intensity-modulated radiotherapy for head-and-neck cancer in the community setting.
Int J Radiat Oncol Biol Phys. 2008 Nov 15; 72(4):1075-81.IJ

Abstract

PURPOSE

To review outcomes with intensity-modulated radiation therapy (IMRT) in the community setting for the treatment of nasopharyngeal and oropharyngeal cancer.

METHODS AND MATERIALS

Between April 2003 and April 2007, 69 patients with histologically confirmed cancer of the nasopharynx and oropharynx underwent IMRT in our practice. The primary sites included nasopharynx (11), base of tongue (18), and tonsil (40). The disease stage distribution was as follows: 2 Stage I, 11 Stage II, 16 Stage III, and 40 Stage IV. All were treated with a simultaneous integrated boost IMRT technique. The median prescribed doses were 70 Gy to the planning target volume, 59.4 Gy to the high-risk subclinical volume, and 54 Gy to the low-risk subclinical volume. Forty-five patients (65%) received concurrent chemotherapy. Toxicity was graded according to the Radiation Therapy Oncology Group toxicity criteria. Progression-free and overall survival rates were estimated with the Kaplan-Meier product-limit method.

RESULTS

Median duration of follow-up was 18 months. The estimated 2-year local control, regional control, distant control, and overall survival rates were 98%, 100%, 98%, and 90%, respectively. The most common acute toxicities were dermatitis (32 Grade 1, 32 Grade 2, 5 Grade 3), mucositis (8 Grade 1, 33 Grade 2, 28 Grade 3), and xerostomia (0 Grade 1, 29 Grade 2, 40 Grade 3).

CONCLUSIONS

Intensity-modulated radiotherapy in the community setting can be accomplished safely and effectively. Systematic internal review systems are recommended for quality control until sufficient experience develops.

Authors+Show Affiliations

Division of Radiation Oncology, The Oregon Clinic, Portland, OR 97213, USA. steven.seung@providence.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

18486355

Citation

Seung, Steven, et al. "Intensity-modulated Radiotherapy for Head-and-neck Cancer in the Community Setting." International Journal of Radiation Oncology, Biology, Physics, vol. 72, no. 4, 2008, pp. 1075-81.
Seung S, Bae J, Solhjem M, et al. Intensity-modulated radiotherapy for head-and-neck cancer in the community setting. Int J Radiat Oncol Biol Phys. 2008;72(4):1075-81.
Seung, S., Bae, J., Solhjem, M., Bader, S., Gannett, D., Hansen, E. K., Louie, J., Underhill, K., & Cha, C. (2008). Intensity-modulated radiotherapy for head-and-neck cancer in the community setting. International Journal of Radiation Oncology, Biology, Physics, 72(4), 1075-81. https://doi.org/10.1016/j.ijrobp.2008.02.016
Seung S, et al. Intensity-modulated Radiotherapy for Head-and-neck Cancer in the Community Setting. Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1075-81. PubMed PMID: 18486355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intensity-modulated radiotherapy for head-and-neck cancer in the community setting. AU - Seung,Steven, AU - Bae,Joseph, AU - Solhjem,Matthew, AU - Bader,Stephen, AU - Gannett,David, AU - Hansen,Eric K, AU - Louie,Jeannie, AU - Underhill,Kelly, AU - Cha,Christine, Y1 - 2008/05/15/ PY - 2007/12/27/received PY - 2008/02/04/revised PY - 2008/02/14/accepted PY - 2008/5/20/pubmed PY - 2008/12/17/medline PY - 2008/5/20/entrez SP - 1075 EP - 81 JF - International journal of radiation oncology, biology, physics JO - Int J Radiat Oncol Biol Phys VL - 72 IS - 4 N2 - PURPOSE: To review outcomes with intensity-modulated radiation therapy (IMRT) in the community setting for the treatment of nasopharyngeal and oropharyngeal cancer. METHODS AND MATERIALS: Between April 2003 and April 2007, 69 patients with histologically confirmed cancer of the nasopharynx and oropharynx underwent IMRT in our practice. The primary sites included nasopharynx (11), base of tongue (18), and tonsil (40). The disease stage distribution was as follows: 2 Stage I, 11 Stage II, 16 Stage III, and 40 Stage IV. All were treated with a simultaneous integrated boost IMRT technique. The median prescribed doses were 70 Gy to the planning target volume, 59.4 Gy to the high-risk subclinical volume, and 54 Gy to the low-risk subclinical volume. Forty-five patients (65%) received concurrent chemotherapy. Toxicity was graded according to the Radiation Therapy Oncology Group toxicity criteria. Progression-free and overall survival rates were estimated with the Kaplan-Meier product-limit method. RESULTS: Median duration of follow-up was 18 months. The estimated 2-year local control, regional control, distant control, and overall survival rates were 98%, 100%, 98%, and 90%, respectively. The most common acute toxicities were dermatitis (32 Grade 1, 32 Grade 2, 5 Grade 3), mucositis (8 Grade 1, 33 Grade 2, 28 Grade 3), and xerostomia (0 Grade 1, 29 Grade 2, 40 Grade 3). CONCLUSIONS: Intensity-modulated radiotherapy in the community setting can be accomplished safely and effectively. Systematic internal review systems are recommended for quality control until sufficient experience develops. SN - 1879-355X UR - https://www.unboundmedicine.com/medline/citation/18486355/Intensity_modulated_radiotherapy_for_head_and_neck_cancer_in_the_community_setting_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(08)00293-9 DB - PRIME DP - Unbound Medicine ER -