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In vivo anti-inflammatory and antinociceptive actions of some Lamium species.
J Ethnopharmacol. 2008 Jun 19; 118(1):166-72.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Several Lamium species have been used to relieve pain in arthritic ailments in Turkish folk medicine.

AIM OF THE STUDY

To evaluate the anti-inflammatory and antinociceptive activities of different extracts prepared with methanol, dichloromethane, n-butanol and water from the aerial parts of some Lamium species of Turkish origin.

MATERIALS AND METHODS

Lamium eriocephalum subsp. eriocephalum, Lamium garganicum subsp. laevigatum, Lamium garganicum subsp. pulchrum and Lamium purpureum var. purpureum (Lamiaceae); for the anti-inflammatory activity, carrageenan-induced hind paw edema model, PGE(2)-induced hind paw edema model, and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema model and for the antinociceptive activity p-benzoquinone (PBQ)-induced writhing test in mice were employed.

RESULTS

The n-butanol extracts of Lamium garganicum subsp. laevigatum (LGL-BuOH), Lamium garganicum subsp. pulchrum (LGP-BuOH), and Lamium purpureum var. purpureum (LPP-BuOH) exhibited notable inhibition (16.5-28.9, 14.5-26.9, 12.3-21.5%, resp.) in carrageenan-induced hind paw edema model at doses of 200mg/kg without inducing any gastric damage. The LGL-BuOH (7.1-30.4%) and LGP-BuOH (5.9-24.1%) extracts also displayed potent anti-inflammatory activity against PGE(2)-induced hind paw edema model. LGL-BuOH and LGP-BuOH were also found to exhibit remarkable antinociceptive activity in p-benzoquinone-induced abdominal constriction test at a dose of 200 mg/kg (25.0 and 24.3%, respectively).

CONCLUSION

The experimental data demonstrated that Lamium garganicum subsp. laevigatum and Lamium garganicum subsp. pulchrum displayed remarkable anti-inflammatory and antinociceptive activities.

Authors+Show Affiliations

Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, Ankara, Turkey. esrak@gazi.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18486371

Citation

Akkol, Esra Küpeli, et al. "In Vivo Anti-inflammatory and Antinociceptive Actions of some Lamium Species." Journal of Ethnopharmacology, vol. 118, no. 1, 2008, pp. 166-72.
Akkol EK, Yalçin FN, Kaya D, et al. In vivo anti-inflammatory and antinociceptive actions of some Lamium species. J Ethnopharmacol. 2008;118(1):166-72.
Akkol, E. K., Yalçin, F. N., Kaya, D., Caliş, I., Yesilada, E., & Ersöz, T. (2008). In vivo anti-inflammatory and antinociceptive actions of some Lamium species. Journal of Ethnopharmacology, 118(1), 166-72. https://doi.org/10.1016/j.jep.2008.04.001
Akkol EK, et al. In Vivo Anti-inflammatory and Antinociceptive Actions of some Lamium Species. J Ethnopharmacol. 2008 Jun 19;118(1):166-72. PubMed PMID: 18486371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo anti-inflammatory and antinociceptive actions of some Lamium species. AU - Akkol,Esra Küpeli, AU - Yalçin,Funda Nuray, AU - Kaya,Duygu, AU - Caliş,Ihsan, AU - Yesilada,Erdem, AU - Ersöz,Tayfun, Y1 - 2008/04/11/ PY - 2008/01/03/received PY - 2008/03/25/revised PY - 2008/04/04/accepted PY - 2008/5/20/pubmed PY - 2008/11/11/medline PY - 2008/5/20/entrez SP - 166 EP - 72 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 118 IS - 1 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Several Lamium species have been used to relieve pain in arthritic ailments in Turkish folk medicine. AIM OF THE STUDY: To evaluate the anti-inflammatory and antinociceptive activities of different extracts prepared with methanol, dichloromethane, n-butanol and water from the aerial parts of some Lamium species of Turkish origin. MATERIALS AND METHODS: Lamium eriocephalum subsp. eriocephalum, Lamium garganicum subsp. laevigatum, Lamium garganicum subsp. pulchrum and Lamium purpureum var. purpureum (Lamiaceae); for the anti-inflammatory activity, carrageenan-induced hind paw edema model, PGE(2)-induced hind paw edema model, and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema model and for the antinociceptive activity p-benzoquinone (PBQ)-induced writhing test in mice were employed. RESULTS: The n-butanol extracts of Lamium garganicum subsp. laevigatum (LGL-BuOH), Lamium garganicum subsp. pulchrum (LGP-BuOH), and Lamium purpureum var. purpureum (LPP-BuOH) exhibited notable inhibition (16.5-28.9, 14.5-26.9, 12.3-21.5%, resp.) in carrageenan-induced hind paw edema model at doses of 200mg/kg without inducing any gastric damage. The LGL-BuOH (7.1-30.4%) and LGP-BuOH (5.9-24.1%) extracts also displayed potent anti-inflammatory activity against PGE(2)-induced hind paw edema model. LGL-BuOH and LGP-BuOH were also found to exhibit remarkable antinociceptive activity in p-benzoquinone-induced abdominal constriction test at a dose of 200 mg/kg (25.0 and 24.3%, respectively). CONCLUSION: The experimental data demonstrated that Lamium garganicum subsp. laevigatum and Lamium garganicum subsp. pulchrum displayed remarkable anti-inflammatory and antinociceptive activities. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18486371/In_vivo_anti_inflammatory_and_antinociceptive_actions_of_some_Lamium_species_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00189-X DB - PRIME DP - Unbound Medicine ER -