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Human chitotriosidase: a potential new marker of sarcoidosis severity.
Respiration. 2008; 76(2):234-8.R

Abstract

Sarcoidosis is a multisystemic granulomatous disorder of unknown etiology. The unpredictable clinical course of the disease has prompted research into biomarkers useful for predicting outcome. Among the potential markers of sarcoidosis, a recently proposed indicator was chitotriosidase, a chitinase produced by activated macrophages. Chitotriosidase is involved in the defense against pathogens containing chitin. Increased concentrations of chitotriosidase have been observed in a number of lysosomal storage diseases including Gaucher disease and more recently also in sarcoidosis. In 2004, significantly higher serum chitotriosidase activity was reported for the first time in sarcoidosis patients with respect to controls (p < 0.01); a similar increase was subsequently observed in bronchoalveolar lavage of these patients. In 2007, an increase in enzyme activity was described in juvenile sarcoidosis. Chitotriosidase activity was found to be correlated with angiotensin-converting enzyme levels in serum, radiological stages and quantitative high-resonance CT score for sarcoidosis, suggesting that this enzyme could be a potential marker of disease severity worthy of further study. To evaluate the sensitivity and specificity of this marker, further analysis was done in other granulomatous and diffuse lung diseases. Here, we review the principal literature and the recent evidence of chitotriosidase as a possible marker of sarcoidosis.

Authors+Show Affiliations

Department of Clinical Medicine and Immunological Sciences, Respiratory Diseases Section, Siena University, Siena, Italy. bargagli2@unisi.itNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18487875

Citation

Bargagli, Elena, et al. "Human Chitotriosidase: a Potential New Marker of Sarcoidosis Severity." Respiration; International Review of Thoracic Diseases, vol. 76, no. 2, 2008, pp. 234-8.
Bargagli E, Maggiorelli C, Rottoli P. Human chitotriosidase: a potential new marker of sarcoidosis severity. Respiration. 2008;76(2):234-8.
Bargagli, E., Maggiorelli, C., & Rottoli, P. (2008). Human chitotriosidase: a potential new marker of sarcoidosis severity. Respiration; International Review of Thoracic Diseases, 76(2), 234-8. https://doi.org/10.1159/000134009
Bargagli E, Maggiorelli C, Rottoli P. Human Chitotriosidase: a Potential New Marker of Sarcoidosis Severity. Respiration. 2008;76(2):234-8. PubMed PMID: 18487875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human chitotriosidase: a potential new marker of sarcoidosis severity. AU - Bargagli,Elena, AU - Maggiorelli,Claudia, AU - Rottoli,Paola, Y1 - 2008/05/19/ PY - 2007/11/19/received PY - 2008/02/07/accepted PY - 2008/5/20/pubmed PY - 2008/12/17/medline PY - 2008/5/20/entrez SP - 234 EP - 8 JF - Respiration; international review of thoracic diseases JO - Respiration VL - 76 IS - 2 N2 - Sarcoidosis is a multisystemic granulomatous disorder of unknown etiology. The unpredictable clinical course of the disease has prompted research into biomarkers useful for predicting outcome. Among the potential markers of sarcoidosis, a recently proposed indicator was chitotriosidase, a chitinase produced by activated macrophages. Chitotriosidase is involved in the defense against pathogens containing chitin. Increased concentrations of chitotriosidase have been observed in a number of lysosomal storage diseases including Gaucher disease and more recently also in sarcoidosis. In 2004, significantly higher serum chitotriosidase activity was reported for the first time in sarcoidosis patients with respect to controls (p < 0.01); a similar increase was subsequently observed in bronchoalveolar lavage of these patients. In 2007, an increase in enzyme activity was described in juvenile sarcoidosis. Chitotriosidase activity was found to be correlated with angiotensin-converting enzyme levels in serum, radiological stages and quantitative high-resonance CT score for sarcoidosis, suggesting that this enzyme could be a potential marker of disease severity worthy of further study. To evaluate the sensitivity and specificity of this marker, further analysis was done in other granulomatous and diffuse lung diseases. Here, we review the principal literature and the recent evidence of chitotriosidase as a possible marker of sarcoidosis. SN - 1423-0356 UR - https://www.unboundmedicine.com/medline/citation/18487875/Human_chitotriosidase:_a_potential_new_marker_of_sarcoidosis_severity_ L2 - https://www.karger.com?DOI=10.1159/000134009 DB - PRIME DP - Unbound Medicine ER -