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Potassium, calcium, magnesium, and sodium levels in biological samples of hypertensive and nonhypertensive diabetes mellitus patients.
Biol Trace Elem Res. 2008 Sep; 124(3):206-24.BT

Abstract

There is accumulating evidence that the metabolism of several essential elements is altered in diabetes mellitus and that these nutrients might have specific roles in the pathogenesis and progress of this disease. The aim of the present study was to compare the level of essential elements, potassium (K), calcium (Ca), magnesium (Mg), and sodium (Na), in biological samples (whole blood, urine, and scalp hair) of patients who have hypertensive diabetes mellitus type 2 (n = 254) and nonhypertensive diabetes mellitus type 2 (n = 228) with those of nondiabetic as control subjects (n = 182; age range of both genders 45-75). The element concentrations were measured by means of an atomic absorption spectrophotometer after microwave-induced acid digestion. The validity and accuracy was checked by conventional wet acid digestion method and using certified reference materials. The overall recoveries of all elements were found in the range of 99.1-99.9% of certified values. The results of this study showed that the mean values of K, Mg, and Ca were significantly reduced, while Na level were higher in blood and scalp hair samples of hypertensive diabetic (HD) patients and nonhypertensive diabetic (NHD) patients as compared to control subjects of both genders (p < 0.05), but level of K in the biological samples of nonhypertensive diabetic patient was found to be higher, but it was not significant (p = 0.05).The urinary levels of these elements were found to be higher in both HD and NHD patients than in the age-matched healthy controls. These results are consistent with those obtained in other studies, confirming that deficiency and efficiency of some essential trace metals may play a role in the development of diabetes mellitus.

Authors+Show Affiliations

National Center of Excellence in Analytical Chemistry, Sindh University, Jamshoro, 76080, Pakistan. hassanimranafridi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18488152

Citation

Afridi, Hassan Imran, et al. "Potassium, Calcium, Magnesium, and Sodium Levels in Biological Samples of Hypertensive and Nonhypertensive Diabetes Mellitus Patients." Biological Trace Element Research, vol. 124, no. 3, 2008, pp. 206-24.
Afridi HI, Kazi TG, Kazi N, et al. Potassium, calcium, magnesium, and sodium levels in biological samples of hypertensive and nonhypertensive diabetes mellitus patients. Biol Trace Elem Res. 2008;124(3):206-24.
Afridi, H. I., Kazi, T. G., Kazi, N., Jamali, M. K., Arain, M. B., Jalbani, N., Sarfaraz, R. A., Shah, A., Kandhro, G. A., Shah, A. Q., & Baig, J. A. (2008). Potassium, calcium, magnesium, and sodium levels in biological samples of hypertensive and nonhypertensive diabetes mellitus patients. Biological Trace Element Research, 124(3), 206-24. https://doi.org/10.1007/s12011-008-8142-7
Afridi HI, et al. Potassium, Calcium, Magnesium, and Sodium Levels in Biological Samples of Hypertensive and Nonhypertensive Diabetes Mellitus Patients. Biol Trace Elem Res. 2008;124(3):206-24. PubMed PMID: 18488152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potassium, calcium, magnesium, and sodium levels in biological samples of hypertensive and nonhypertensive diabetes mellitus patients. AU - Afridi,Hassan Imran, AU - Kazi,Tasneem Gul, AU - Kazi,Naveed, AU - Jamali,Mohammad Khan, AU - Arain,Mohammad Bilal, AU - Jalbani,Nusrst, AU - Sarfaraz,Raja Adil, AU - Shah,Afzal, AU - Kandhro,Ghulam Abbas, AU - Shah,Abdul Qadir, AU - Baig,Jameel Ahmed, Y1 - 2008/05/17/ PY - 2008/04/09/received PY - 2008/04/11/accepted PY - 2008/5/20/pubmed PY - 2009/1/13/medline PY - 2008/5/20/entrez SP - 206 EP - 24 JF - Biological trace element research JO - Biol Trace Elem Res VL - 124 IS - 3 N2 - There is accumulating evidence that the metabolism of several essential elements is altered in diabetes mellitus and that these nutrients might have specific roles in the pathogenesis and progress of this disease. The aim of the present study was to compare the level of essential elements, potassium (K), calcium (Ca), magnesium (Mg), and sodium (Na), in biological samples (whole blood, urine, and scalp hair) of patients who have hypertensive diabetes mellitus type 2 (n = 254) and nonhypertensive diabetes mellitus type 2 (n = 228) with those of nondiabetic as control subjects (n = 182; age range of both genders 45-75). The element concentrations were measured by means of an atomic absorption spectrophotometer after microwave-induced acid digestion. The validity and accuracy was checked by conventional wet acid digestion method and using certified reference materials. The overall recoveries of all elements were found in the range of 99.1-99.9% of certified values. The results of this study showed that the mean values of K, Mg, and Ca were significantly reduced, while Na level were higher in blood and scalp hair samples of hypertensive diabetic (HD) patients and nonhypertensive diabetic (NHD) patients as compared to control subjects of both genders (p < 0.05), but level of K in the biological samples of nonhypertensive diabetic patient was found to be higher, but it was not significant (p = 0.05).The urinary levels of these elements were found to be higher in both HD and NHD patients than in the age-matched healthy controls. These results are consistent with those obtained in other studies, confirming that deficiency and efficiency of some essential trace metals may play a role in the development of diabetes mellitus. SN - 0163-4984 UR - https://www.unboundmedicine.com/medline/citation/18488152/Potassium_calcium_magnesium_and_sodium_levels_in_biological_samples_of_hypertensive_and_nonhypertensive_diabetes_mellitus_patients_ L2 - https://dx.doi.org/10.1007/s12011-008-8142-7 DB - PRIME DP - Unbound Medicine ER -