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Antioxidant protection of resveratrol and catechin in Saccharomyces cerevisiae.
J Agric Food Chem. 2008 Jun 11; 56(11):4268-72.JA

Abstract

Moderate consumption of red wine reduces the risk of heart disease and extends lifespan, but the relative contribution of wine polyphenols to these effects is unclear. In this work, the capacity of resveratrol and catechin to protect the eukaryotic microorganism Saccharomyces cerevisiae against oxidative stress caused by different agents, hydrogen peroxide, carbon tetrachloride, and cadmium, was evaluated. Under all stress conditions, both polyphenols increased tolerance, although their protection was more evident under peroxide exposure. By using mutant strains deficient in specific antioxidant defense systems (superoxide dismutases, catalase, or glutathione), it was observed that increased H2O2 tolerance produced by both polyphenols was associated with catalase, as well as the rise in survival rates caused by resveratrol under CCl4. The acquisition of tolerance was correlated with a reduction in lipid peroxidation, indicating that the antioxidant property of resveratrol and catechin involves protection against membrane oxidation.

Authors+Show Affiliations

Universidade de Caxias do Sul, Institute Quimica, UFRJ, and Dep. Biofísica, UFRGS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18489120

Citation

Dani, Caroline, et al. "Antioxidant Protection of Resveratrol and Catechin in Saccharomyces Cerevisiae." Journal of Agricultural and Food Chemistry, vol. 56, no. 11, 2008, pp. 4268-72.
Dani C, Bonatto D, Salvador M, et al. Antioxidant protection of resveratrol and catechin in Saccharomyces cerevisiae. J Agric Food Chem. 2008;56(11):4268-72.
Dani, C., Bonatto, D., Salvador, M., Pereira, M. D., Henriques, J. A., & Eleutherio, E. (2008). Antioxidant protection of resveratrol and catechin in Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry, 56(11), 4268-72. https://doi.org/10.1021/jf800752s
Dani C, et al. Antioxidant Protection of Resveratrol and Catechin in Saccharomyces Cerevisiae. J Agric Food Chem. 2008 Jun 11;56(11):4268-72. PubMed PMID: 18489120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant protection of resveratrol and catechin in Saccharomyces cerevisiae. AU - Dani,Caroline, AU - Bonatto,Diego, AU - Salvador,Mirian, AU - Pereira,Marcos D, AU - Henriques,João A P, AU - Eleutherio,Elis, Y1 - 2008/05/20/ PY - 2008/5/21/pubmed PY - 2008/7/31/medline PY - 2008/5/21/entrez SP - 4268 EP - 72 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 56 IS - 11 N2 - Moderate consumption of red wine reduces the risk of heart disease and extends lifespan, but the relative contribution of wine polyphenols to these effects is unclear. In this work, the capacity of resveratrol and catechin to protect the eukaryotic microorganism Saccharomyces cerevisiae against oxidative stress caused by different agents, hydrogen peroxide, carbon tetrachloride, and cadmium, was evaluated. Under all stress conditions, both polyphenols increased tolerance, although their protection was more evident under peroxide exposure. By using mutant strains deficient in specific antioxidant defense systems (superoxide dismutases, catalase, or glutathione), it was observed that increased H2O2 tolerance produced by both polyphenols was associated with catalase, as well as the rise in survival rates caused by resveratrol under CCl4. The acquisition of tolerance was correlated with a reduction in lipid peroxidation, indicating that the antioxidant property of resveratrol and catechin involves protection against membrane oxidation. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/18489120/Antioxidant_protection_of_resveratrol_and_catechin_in_Saccharomyces_cerevisiae_ L2 - https://doi.org/10.1021/jf800752s DB - PRIME DP - Unbound Medicine ER -