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[Acute generalized exanthematous pustulosis associated with diltiazem].
Acta Med Port. 2008 Jan-Feb; 21(1):99-102.AM

Abstract

Acute generalized exanthematous pustulosis (AGEP) usually presents with the acute appearance of oedematous and erythematous lesions, on which multiple sterile pustules appear, associated with fever. Almost 90% of cases are associated with drugs, with antibiotics (penicillins and macrolides) being the most frequent causative agents. We describe a 36-year-old female patient, which started diltiazem 120mg/day for hypertension. After 6 days of therapy, multiple erythematous and oedematous lesions appeared, with associated multiple small non-follicular pustules. Oral corticosteroids were started, with progressive and complete improvement. Patch-tests were performed, which revealed positivity for diltiazem. Although a rare entity, AGEP must be considered in cases of acute eruptions with disseminated pustules and fever. The use of patch tests in this disease may be useful as positive reactions are frequent.

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Authors+Show Affiliations

Serrão V
Serviço de Dermatologia, Hospital dos Capuchos, Lisboa.
Caldas Lopes L
No affiliation info available
Campos Lopes JM
No affiliation info available
Lobo L
No affiliation info available
Ferreira A
No affiliation info available

MeSH

Acute DiseaseAdultAntihypertensive AgentsDiltiazemDrug EruptionsExanthemaFemaleHumansSkin Diseases, Vesiculobullous

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

por

PubMed ID

18489841

Citation

Serrão, Vasco, et al. "[Acute Generalized Exanthematous Pustulosis Associated With Diltiazem]." Acta Medica Portuguesa, vol. 21, no. 1, 2008, pp. 99-102.
Serrão V, Caldas Lopes L, Campos Lopes JM, et al. [Acute generalized exanthematous pustulosis associated with diltiazem]. Acta Med Port. 2008;21(1):99-102.
Serrão, V., Caldas Lopes, L., Campos Lopes, J. M., Lobo, L., & Ferreira, A. (2008). [Acute generalized exanthematous pustulosis associated with diltiazem]. Acta Medica Portuguesa, 21(1), 99-102.
Serrão V, et al. [Acute Generalized Exanthematous Pustulosis Associated With Diltiazem]. Acta Med Port. 2008 Jan-Feb;21(1):99-102. PubMed PMID: 18489841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Acute generalized exanthematous pustulosis associated with diltiazem]. AU - Serrão,Vasco, AU - Caldas Lopes,Luísa, AU - Campos Lopes,J M, AU - Lobo,Lurdes, AU - Ferreira,Ana, Y1 - 2008/04/18/ PY - 2007/06/08/received PY - 2007/12/12/accepted PY - 2008/5/21/pubmed PY - 2008/9/19/medline PY - 2008/5/21/entrez SP - 99 EP - 102 JF - Acta medica portuguesa JO - Acta Med Port VL - 21 IS - 1 N2 - Acute generalized exanthematous pustulosis (AGEP) usually presents with the acute appearance of oedematous and erythematous lesions, on which multiple sterile pustules appear, associated with fever. Almost 90% of cases are associated with drugs, with antibiotics (penicillins and macrolides) being the most frequent causative agents. We describe a 36-year-old female patient, which started diltiazem 120mg/day for hypertension. After 6 days of therapy, multiple erythematous and oedematous lesions appeared, with associated multiple small non-follicular pustules. Oral corticosteroids were started, with progressive and complete improvement. Patch-tests were performed, which revealed positivity for diltiazem. Although a rare entity, AGEP must be considered in cases of acute eruptions with disseminated pustules and fever. The use of patch tests in this disease may be useful as positive reactions are frequent. SN - 1646-0758 UR - https://www.unboundmedicine.com/medline/citation/18489841/[Acute_generalized_exanthematous_pustulosis_associated_with_diltiazem]_ L2 - http://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/757/434 DB - PRIME DP - Unbound Medicine ER -