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Changes in right ventricular structure and function assessed using cardiac magnetic resonance imaging in bosentan-treated patients with pulmonary arterial hypertension.
Am J Cardiol. 2008 Jun 01; 101(11):1669-72.AJ

Abstract

Patients with pulmonary arterial hypertension (PAH) usually show improvements in symptoms, exercise capacity, and hemodynamics after treatment with approved medical therapies. This study sought to determine whether improvement in right-sided cardiac function measured using cardiac magnetic resonance imaging would also be seen and whether these changes would correlate with improvement in exercise capacity. Sixteen patients with PAH underwent evaluation at baseline and after 12 months of treatment with bosentan. After treatment, cardiac index, pulmonary vascular resistance, and 6-minute walk distance improved, and there was a trend toward improvement in right ventricular (RV) stroke volume (70 +/- 27 to 81 +/- 30 ml; p = 0.08), but no change in RV ejection fraction (RVEF) or RV end-diastolic volume. Six-minute walk distance improved by 59 m (p <0.05) in the overall cohort and improved more in patients in whom RVEF increased compared with those with stable or decreased RVEF (+98 vs -37 m, respectively; p = 0.01). Three patients died during follow-up, and these patients had significantly lower RVEF and left ventricular end-diastolic volume indexes than surviving patients. In conclusion, these results suggest that cardiac magnetic resonance imaging may have value in determining response to therapy and prognosis in patients with PAH.

Authors+Show Affiliations

UT Southwestern Medical Center, Dallas, Texas, USA. kelly.chin@utsouthwestern.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18489949

Citation

Chin, Kelly M., et al. "Changes in Right Ventricular Structure and Function Assessed Using Cardiac Magnetic Resonance Imaging in Bosentan-treated Patients With Pulmonary Arterial Hypertension." The American Journal of Cardiology, vol. 101, no. 11, 2008, pp. 1669-72.
Chin KM, Kingman M, de Lemos JA, et al. Changes in right ventricular structure and function assessed using cardiac magnetic resonance imaging in bosentan-treated patients with pulmonary arterial hypertension. Am J Cardiol. 2008;101(11):1669-72.
Chin, K. M., Kingman, M., de Lemos, J. A., Warner, J. J., Reimold, S., Peshock, R., & Torres, F. (2008). Changes in right ventricular structure and function assessed using cardiac magnetic resonance imaging in bosentan-treated patients with pulmonary arterial hypertension. The American Journal of Cardiology, 101(11), 1669-72. https://doi.org/10.1016/j.amjcard.2008.01.055
Chin KM, et al. Changes in Right Ventricular Structure and Function Assessed Using Cardiac Magnetic Resonance Imaging in Bosentan-treated Patients With Pulmonary Arterial Hypertension. Am J Cardiol. 2008 Jun 1;101(11):1669-72. PubMed PMID: 18489949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in right ventricular structure and function assessed using cardiac magnetic resonance imaging in bosentan-treated patients with pulmonary arterial hypertension. AU - Chin,Kelly M, AU - Kingman,Martha, AU - de Lemos,James A, AU - Warner,John J, AU - Reimold,Sharon, AU - Peshock,Ron, AU - Torres,Fernando, Y1 - 2008/04/18/ PY - 2007/10/28/received PY - 2008/01/21/revised PY - 2008/01/21/accepted PY - 2008/5/21/pubmed PY - 2008/7/17/medline PY - 2008/5/21/entrez SP - 1669 EP - 72 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 101 IS - 11 N2 - Patients with pulmonary arterial hypertension (PAH) usually show improvements in symptoms, exercise capacity, and hemodynamics after treatment with approved medical therapies. This study sought to determine whether improvement in right-sided cardiac function measured using cardiac magnetic resonance imaging would also be seen and whether these changes would correlate with improvement in exercise capacity. Sixteen patients with PAH underwent evaluation at baseline and after 12 months of treatment with bosentan. After treatment, cardiac index, pulmonary vascular resistance, and 6-minute walk distance improved, and there was a trend toward improvement in right ventricular (RV) stroke volume (70 +/- 27 to 81 +/- 30 ml; p = 0.08), but no change in RV ejection fraction (RVEF) or RV end-diastolic volume. Six-minute walk distance improved by 59 m (p <0.05) in the overall cohort and improved more in patients in whom RVEF increased compared with those with stable or decreased RVEF (+98 vs -37 m, respectively; p = 0.01). Three patients died during follow-up, and these patients had significantly lower RVEF and left ventricular end-diastolic volume indexes than surviving patients. In conclusion, these results suggest that cardiac magnetic resonance imaging may have value in determining response to therapy and prognosis in patients with PAH. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/18489949/Changes_in_right_ventricular_structure_and_function_assessed_using_cardiac_magnetic_resonance_imaging_in_bosentan_treated_patients_with_pulmonary_arterial_hypertension_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(08)00264-6 DB - PRIME DP - Unbound Medicine ER -