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Dietary flavonoid intake and risk of cancer in postmenopausal women: the Iowa Women's Health Study.
Int J Cancer 2008; 123(3):664-71IJ

Abstract

Flavonoids, which are found in certain plant foods, are thought to lower cancer risk through their antioxidant, antiestrogenic and antiproliferative properties. We examined the association of intake of total flavonoids and 7 flavonoid subclasses with risk of lung, colorectal, breast, pancreatic and upper aerodigestive cancer among women in a large prospective cohort study. Study participants were 34,708 postmenopausal women in the Iowa Women's Health Study who completed a food frequency questionnaire and were followed for cancer occurrence from 1986 through 2004. Flavonoid intake was estimated from 3 databases developed by the USDA Nutrient Data Laboratory (NDL). Hazard ratios (HR) for cancer risk were calculated across total flavonoid and flavonoid subclass intake categories. Interactions between smoking history and flavonoid intake were also examined. After multivariable adjustment, lung cancer incidence was inversely associated with intakes of flavanones (HR = 0.68; 95% CI: 0.53-0.86, all results highest vs. lowest quintile) and proanthocyanidins (HR = 0.75; 95% CI: 0.57-0.97). Among current and past smokers, those with intakes in the highest quintile for flavanones (HR = 0.66; 95% CI: 0.50-0.86), and proanthocyanidins (HR = 0.66; 95% CI; 0.49-0.89) had significantly lower lung cancer incidence than those in the lowest quintile. Similar associations were not seen in never smokers. Isoflavone intake was inversely associated with overall cancer incidence (HR = 0.93, 95% CI: 0.86-1.00). This study provides further support for a beneficial effect of flavonoid intake on lung cancer risk, especially among current and past smokers.

Authors+Show Affiliations

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18491403

Citation

Cutler, Gretchen J., et al. "Dietary Flavonoid Intake and Risk of Cancer in Postmenopausal Women: the Iowa Women's Health Study." International Journal of Cancer, vol. 123, no. 3, 2008, pp. 664-71.
Cutler GJ, Nettleton JA, Ross JA, et al. Dietary flavonoid intake and risk of cancer in postmenopausal women: the Iowa Women's Health Study. Int J Cancer. 2008;123(3):664-71.
Cutler, G. J., Nettleton, J. A., Ross, J. A., Harnack, L. J., Jacobs, D. R., Scrafford, C. G., ... Robien, K. (2008). Dietary flavonoid intake and risk of cancer in postmenopausal women: the Iowa Women's Health Study. International Journal of Cancer, 123(3), pp. 664-71. doi:10.1002/ijc.23564.
Cutler GJ, et al. Dietary Flavonoid Intake and Risk of Cancer in Postmenopausal Women: the Iowa Women's Health Study. Int J Cancer. 2008 Aug 1;123(3):664-71. PubMed PMID: 18491403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary flavonoid intake and risk of cancer in postmenopausal women: the Iowa Women's Health Study. AU - Cutler,Gretchen J, AU - Nettleton,Jennifer A, AU - Ross,Julie A, AU - Harnack,Lisa J, AU - Jacobs,David R,Jr AU - Scrafford,Carolyn G, AU - Barraj,Leila M, AU - Mink,Pamela J, AU - Robien,Kim, PY - 2008/5/21/pubmed PY - 2008/7/4/medline PY - 2008/5/21/entrez SP - 664 EP - 71 JF - International journal of cancer JO - Int. J. Cancer VL - 123 IS - 3 N2 - Flavonoids, which are found in certain plant foods, are thought to lower cancer risk through their antioxidant, antiestrogenic and antiproliferative properties. We examined the association of intake of total flavonoids and 7 flavonoid subclasses with risk of lung, colorectal, breast, pancreatic and upper aerodigestive cancer among women in a large prospective cohort study. Study participants were 34,708 postmenopausal women in the Iowa Women's Health Study who completed a food frequency questionnaire and were followed for cancer occurrence from 1986 through 2004. Flavonoid intake was estimated from 3 databases developed by the USDA Nutrient Data Laboratory (NDL). Hazard ratios (HR) for cancer risk were calculated across total flavonoid and flavonoid subclass intake categories. Interactions between smoking history and flavonoid intake were also examined. After multivariable adjustment, lung cancer incidence was inversely associated with intakes of flavanones (HR = 0.68; 95% CI: 0.53-0.86, all results highest vs. lowest quintile) and proanthocyanidins (HR = 0.75; 95% CI: 0.57-0.97). Among current and past smokers, those with intakes in the highest quintile for flavanones (HR = 0.66; 95% CI: 0.50-0.86), and proanthocyanidins (HR = 0.66; 95% CI; 0.49-0.89) had significantly lower lung cancer incidence than those in the lowest quintile. Similar associations were not seen in never smokers. Isoflavone intake was inversely associated with overall cancer incidence (HR = 0.93, 95% CI: 0.86-1.00). This study provides further support for a beneficial effect of flavonoid intake on lung cancer risk, especially among current and past smokers. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/18491403/Dietary_flavonoid_intake_and_risk_of_cancer_in_postmenopausal_women:_the_Iowa_Women's_Health_Study_ L2 - https://doi.org/10.1002/ijc.23564 DB - PRIME DP - Unbound Medicine ER -