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Oral and intestinal Candida colonization in patients undergoing hematopoietic stem-cell transplantation.
J Infect Dis. 2008 Jul 01; 198(1):150-3.JI

Abstract

We investigated (1) the prevalence and quantity of, as well as risk factors for, orointestinal Candida colonization in patients undergoing hematopoietic stem-cell transplantation (HSCT) and (2) the genetic relatedness of colonizing C. albicans strains. Mouth-wash and stool samples were collected from 77 patients before they underwent HSCT and on days 1, 8, and 15 and were quantitatively cultured. C. albicans isolates were genotyped by microsatellite-marker analysis. The prevalence and quantity of orointestinal Candida colonization varied over time. In 48% (13/27) of multicolonized patients, the same Candida genotype was present in oral and intestinal samples. Oral colonization and decontamination of the gut by vancomycin and paromomycin were risk factors for intestinal Candida colonization.

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Authors+Show Affiliations

Zollner-Schwetz I
Division of Infectious Diseases, Department of Pulmonology, Medical University of Graz, Graz, Austria.
Auner HW
No affiliation info available
Paulitsch A
No affiliation info available
Buzina W
No affiliation info available
Staber PB
No affiliation info available
Ofner-Kopeinig P
No affiliation info available
Reisinger EC
No affiliation info available
Olschewski H
No affiliation info available
Krause R
No affiliation info available

MeSH

AdultAgedAnti-Bacterial AgentsCandida albicansCandidiasisCarrier StateFemaleHematopoietic Stem Cell TransplantationHumansImmunocompromised HostIntestinesMaleMiddle AgedMouthParomomycinPrevalenceRisk FactorsVancomycin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18491972

Citation

Zollner-Schwetz, Ines, et al. "Oral and Intestinal Candida Colonization in Patients Undergoing Hematopoietic Stem-cell Transplantation." The Journal of Infectious Diseases, vol. 198, no. 1, 2008, pp. 150-3.
Zollner-Schwetz I, Auner HW, Paulitsch A, et al. Oral and intestinal Candida colonization in patients undergoing hematopoietic stem-cell transplantation. J Infect Dis. 2008;198(1):150-3.
Zollner-Schwetz, I., Auner, H. W., Paulitsch, A., Buzina, W., Staber, P. B., Ofner-Kopeinig, P., Reisinger, E. C., Olschewski, H., & Krause, R. (2008). Oral and intestinal Candida colonization in patients undergoing hematopoietic stem-cell transplantation. The Journal of Infectious Diseases, 198(1), 150-3. https://doi.org/10.1086/588827
Zollner-Schwetz I, et al. Oral and Intestinal Candida Colonization in Patients Undergoing Hematopoietic Stem-cell Transplantation. J Infect Dis. 2008 Jul 1;198(1):150-3. PubMed PMID: 18491972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral and intestinal Candida colonization in patients undergoing hematopoietic stem-cell transplantation. AU - Zollner-Schwetz,Ines, AU - Auner,Holger W, AU - Paulitsch,Astrid, AU - Buzina,Walter, AU - Staber,Philipp B, AU - Ofner-Kopeinig,Petra, AU - Reisinger,Emil C, AU - Olschewski,Horst, AU - Krause,Robert, PY - 2008/5/22/pubmed PY - 2008/7/31/medline PY - 2008/5/22/entrez SP - 150 EP - 3 JF - The Journal of infectious diseases JO - J Infect Dis VL - 198 IS - 1 N2 - We investigated (1) the prevalence and quantity of, as well as risk factors for, orointestinal Candida colonization in patients undergoing hematopoietic stem-cell transplantation (HSCT) and (2) the genetic relatedness of colonizing C. albicans strains. Mouth-wash and stool samples were collected from 77 patients before they underwent HSCT and on days 1, 8, and 15 and were quantitatively cultured. C. albicans isolates were genotyped by microsatellite-marker analysis. The prevalence and quantity of orointestinal Candida colonization varied over time. In 48% (13/27) of multicolonized patients, the same Candida genotype was present in oral and intestinal samples. Oral colonization and decontamination of the gut by vancomycin and paromomycin were risk factors for intestinal Candida colonization. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/18491972/Oral_and_intestinal_Candida_colonization_in_patients_undergoing_hematopoietic_stem_cell_transplantation_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/588827 DB - PRIME DP - Unbound Medicine ER -