Tags

Type your tag names separated by a space and hit enter

Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility.
J Child Psychol Psychiatry. 2008 Oct; 49(10):1020-30.JC

Abstract

Attention-deficit hyperactivity disorder (ADHD) is a common childhood neurobehavioural disorder defined by symptoms of developmentally inappropriate inattention, impulsivity and hyperactivity. As is the norm for most psychiatric phenotypes, traditional aetiological studies have focused primarily on the interplay between genetic and environmental factors. It is likely that epigenetic factors, i.e., heritable, but reversible changes to genomic function that are independent of DNA sequence, are also important. It is known that epigenetic processes can be induced following exposure to a range of external factors, and thus provide a mechanism by which the environment can lead to long-term alterations in phenotype. In this article we hypothesise that epigenetic dysregulation may mediate the association observed between early-development environmental insults and ADHD. We propose that understanding the epigenetic processes involved in linking specific environmental pathogens to an increased risk for ADHD may offer new possibilities for preventative and therapeutic intervention.

Authors+Show Affiliations

Institute of Psychiatry, SGDP Research Centre, London, UK. jonathan.mill@iop.kcl.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18492038

Citation

Mill, Jonathan, and Arturas Petronis. "Pre- and Peri-natal Environmental Risks for Attention-deficit Hyperactivity Disorder (ADHD): the Potential Role of Epigenetic Processes in Mediating Susceptibility." Journal of Child Psychology and Psychiatry, and Allied Disciplines, vol. 49, no. 10, 2008, pp. 1020-30.
Mill J, Petronis A. Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility. J Child Psychol Psychiatry. 2008;49(10):1020-30.
Mill, J., & Petronis, A. (2008). Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 49(10), 1020-30. https://doi.org/10.1111/j.1469-7610.2008.01909.x
Mill J, Petronis A. Pre- and Peri-natal Environmental Risks for Attention-deficit Hyperactivity Disorder (ADHD): the Potential Role of Epigenetic Processes in Mediating Susceptibility. J Child Psychol Psychiatry. 2008;49(10):1020-30. PubMed PMID: 18492038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility. AU - Mill,Jonathan, AU - Petronis,Arturas, Y1 - 2008/05/19/ PY - 2008/5/22/pubmed PY - 2009/3/6/medline PY - 2008/5/22/entrez SP - 1020 EP - 30 JF - Journal of child psychology and psychiatry, and allied disciplines JO - J Child Psychol Psychiatry VL - 49 IS - 10 N2 - Attention-deficit hyperactivity disorder (ADHD) is a common childhood neurobehavioural disorder defined by symptoms of developmentally inappropriate inattention, impulsivity and hyperactivity. As is the norm for most psychiatric phenotypes, traditional aetiological studies have focused primarily on the interplay between genetic and environmental factors. It is likely that epigenetic factors, i.e., heritable, but reversible changes to genomic function that are independent of DNA sequence, are also important. It is known that epigenetic processes can be induced following exposure to a range of external factors, and thus provide a mechanism by which the environment can lead to long-term alterations in phenotype. In this article we hypothesise that epigenetic dysregulation may mediate the association observed between early-development environmental insults and ADHD. We propose that understanding the epigenetic processes involved in linking specific environmental pathogens to an increased risk for ADHD may offer new possibilities for preventative and therapeutic intervention. SN - 1469-7610 UR - https://www.unboundmedicine.com/medline/citation/18492038/Pre__and_peri_natal_environmental_risks_for_attention_deficit_hyperactivity_disorder__ADHD_:_the_potential_role_of_epigenetic_processes_in_mediating_susceptibility_ L2 - https://doi.org/10.1111/j.1469-7610.2008.01909.x DB - PRIME DP - Unbound Medicine ER -