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Similar cytokine profiles in response to infection with respiratory syncytial virus type a and type B in the upper respiratory tract in infants.
Intervirology. 2008; 51(2):112-5.I

Abstract

Human respiratory syncytial virus (RSV) is the leading viral cause of severe respiratory illness in infants and young children worldwide. RSV isolates can be divided into 2 subgroups, type A and type B. Here, we compare for the first time the nasal profiles of 27 immune mediators in response to both viral subtypes in 14 children infected with RSV/A, 8 children infected with RSV/B, 11 children coinfected with RSV/A plus other respiratory viruses, and finally, 27 control children, all <2 years old. Our results evidence that children's infection with both RSV subtypes induces very similar profiles of immune mediators in the upper respiratory tract, characterized by the elevation of Th1 and Th2 cytokines, chemokines and growth factors. Interestingly, no major differences in the profiles of the immune mediators were found between the children infected exclusively with RSV/A and those infected with RSV/A plus other respiratory viruses.

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Authors+Show Affiliations

Bermejo-Martin JF
Laboratorio de Inmunología de Mucosas, IBGM, Universidad de Valladolid, Valladolid, Spain. bermejo@ped.uva.es
Tenorio A
No affiliation info available
Ortiz de Lejarazu R
No affiliation info available
Eiros JM
No affiliation info available
Matías V
No affiliation info available
Dominguez-Gil M
No affiliation info available
Pino M
No affiliation info available
Alonso A
No affiliation info available
Blanco-Quiros A
No affiliation info available
Arranz E
No affiliation info available
Ardura J
No affiliation info available

MeSH

CytokinesFemaleHumansInfantMaleNasopharynxRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus, HumanRespiratory Tract InfectionsTh1 CellsTh2 Cells

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18493154

Citation

Bermejo-Martin, Jesus F., et al. "Similar Cytokine Profiles in Response to Infection With Respiratory Syncytial Virus Type a and Type B in the Upper Respiratory Tract in Infants." Intervirology, vol. 51, no. 2, 2008, pp. 112-5.
Bermejo-Martin JF, Tenorio A, Ortiz de Lejarazu R, et al. Similar cytokine profiles in response to infection with respiratory syncytial virus type a and type B in the upper respiratory tract in infants. Intervirology. 2008;51(2):112-5.
Bermejo-Martin, J. F., Tenorio, A., Ortiz de Lejarazu, R., Eiros, J. M., Matías, V., Dominguez-Gil, M., Pino, M., Alonso, A., Blanco-Quiros, A., Arranz, E., & Ardura, J. (2008). Similar cytokine profiles in response to infection with respiratory syncytial virus type a and type B in the upper respiratory tract in infants. Intervirology, 51(2), 112-5. https://doi.org/10.1159/000134268
Bermejo-Martin JF, et al. Similar Cytokine Profiles in Response to Infection With Respiratory Syncytial Virus Type a and Type B in the Upper Respiratory Tract in Infants. Intervirology. 2008;51(2):112-5. PubMed PMID: 18493154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Similar cytokine profiles in response to infection with respiratory syncytial virus type a and type B in the upper respiratory tract in infants. AU - Bermejo-Martin,Jesus F, AU - Tenorio,Alberto, AU - Ortiz de Lejarazu,Raul, AU - Eiros,Jose M, AU - Matías,Vanesa, AU - Dominguez-Gil,Marta, AU - Pino,Maria, AU - Alonso,Ana, AU - Blanco-Quiros,Alfredo, AU - Arranz,Eduardo, AU - Ardura,Julio, Y1 - 2008/05/21/ PY - 2007/09/04/received PY - 2008/03/04/accepted PY - 2008/5/22/pubmed PY - 2008/9/3/medline PY - 2008/5/22/entrez SP - 112 EP - 5 JF - Intervirology JO - Intervirology VL - 51 IS - 2 N2 - Human respiratory syncytial virus (RSV) is the leading viral cause of severe respiratory illness in infants and young children worldwide. RSV isolates can be divided into 2 subgroups, type A and type B. Here, we compare for the first time the nasal profiles of 27 immune mediators in response to both viral subtypes in 14 children infected with RSV/A, 8 children infected with RSV/B, 11 children coinfected with RSV/A plus other respiratory viruses, and finally, 27 control children, all <2 years old. Our results evidence that children's infection with both RSV subtypes induces very similar profiles of immune mediators in the upper respiratory tract, characterized by the elevation of Th1 and Th2 cytokines, chemokines and growth factors. Interestingly, no major differences in the profiles of the immune mediators were found between the children infected exclusively with RSV/A and those infected with RSV/A plus other respiratory viruses. SN - 1423-0100 UR - https://www.unboundmedicine.com/medline/citation/18493154/Similar_cytokine_profiles_in_response_to_infection_with_respiratory_syncytial_virus_type_a_and_type_B_in_the_upper_respiratory_tract_in_infants_ L2 - https://www.karger.com?DOI=10.1159/000134268 DB - PRIME DP - Unbound Medicine ER -