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Alcohol and risk of lung cancer among Japanese men: data from a large-scale population-based cohort study, the JPHC study.
Cancer Causes Control. 2008 Dec; 19(10):1095-102.CC

Abstract

OBJECTIVE

Although large-scale studies, including meta-analyses, on the association between alcohol consumption and lung cancer have been reported, the risk of lung cancer in extremely high consumption groups (>or=450 g ethanol/week) in both current smokers and nonsmokers remains unclear. Here, we investigated the association between alcohol consumption and lung cancer incidence.

METHODS

We conducted a population-based prospective cohort study in 46,347 Japanese men aged 40-69 years with no history of cancer at baseline in 1990-1994. We used Cox proportional hazards regression analysis to estimate the hazard ratio (HR) and 95% confidence interval (CI) of lung cancer incidence according to alcohol consumption.

RESULTS

During the 14-year follow-up period, we documented 651 cases of lung cancer. We found a positive association between alcohol consumption and lung cancer risk confined to current smokers. Compared with occasional drinkers, the multivariate HRs (95% CI) in the highest category (>or=450 g ethanol/week) were 1.31 (0.89-1.94) among total participants, 0.58 (0.26-1.30) (p for trend = 0.49) among nonsmokers, and 1.69 (1.05-2.72) (p for trend = 0.02) among current smokers.

CONCLUSIONS

Among this population with a large variation in alcohol consumption, alcohol consumption was not an independent risk factor for lung cancer except for current smokers.

Authors+Show Affiliations

Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan. tshimazu@gan2.res.ncc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18493860

Citation

Shimazu, Taichi, et al. "Alcohol and Risk of Lung Cancer Among Japanese Men: Data From a Large-scale Population-based Cohort Study, the JPHC Study." Cancer Causes & Control : CCC, vol. 19, no. 10, 2008, pp. 1095-102.
Shimazu T, Inoue M, Sasazuki S, et al. Alcohol and risk of lung cancer among Japanese men: data from a large-scale population-based cohort study, the JPHC study. Cancer Causes Control. 2008;19(10):1095-102.
Shimazu, T., Inoue, M., Sasazuki, S., Iwasaki, M., Kurahashi, N., Yamaji, T., & Tsugane, S. (2008). Alcohol and risk of lung cancer among Japanese men: data from a large-scale population-based cohort study, the JPHC study. Cancer Causes & Control : CCC, 19(10), 1095-102. https://doi.org/10.1007/s10552-008-9173-2
Shimazu T, et al. Alcohol and Risk of Lung Cancer Among Japanese Men: Data From a Large-scale Population-based Cohort Study, the JPHC Study. Cancer Causes Control. 2008;19(10):1095-102. PubMed PMID: 18493860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol and risk of lung cancer among Japanese men: data from a large-scale population-based cohort study, the JPHC study. AU - Shimazu,Taichi, AU - Inoue,Manami, AU - Sasazuki,Shizuka, AU - Iwasaki,Motoki, AU - Kurahashi,Norie, AU - Yamaji,Taiki, AU - Tsugane,Shoichiro, AU - ,, Y1 - 2008/05/21/ PY - 2007/10/18/received PY - 2008/04/29/accepted PY - 2008/5/22/pubmed PY - 2009/2/13/medline PY - 2008/5/22/entrez SP - 1095 EP - 102 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 19 IS - 10 N2 - OBJECTIVE: Although large-scale studies, including meta-analyses, on the association between alcohol consumption and lung cancer have been reported, the risk of lung cancer in extremely high consumption groups (>or=450 g ethanol/week) in both current smokers and nonsmokers remains unclear. Here, we investigated the association between alcohol consumption and lung cancer incidence. METHODS: We conducted a population-based prospective cohort study in 46,347 Japanese men aged 40-69 years with no history of cancer at baseline in 1990-1994. We used Cox proportional hazards regression analysis to estimate the hazard ratio (HR) and 95% confidence interval (CI) of lung cancer incidence according to alcohol consumption. RESULTS: During the 14-year follow-up period, we documented 651 cases of lung cancer. We found a positive association between alcohol consumption and lung cancer risk confined to current smokers. Compared with occasional drinkers, the multivariate HRs (95% CI) in the highest category (>or=450 g ethanol/week) were 1.31 (0.89-1.94) among total participants, 0.58 (0.26-1.30) (p for trend = 0.49) among nonsmokers, and 1.69 (1.05-2.72) (p for trend = 0.02) among current smokers. CONCLUSIONS: Among this population with a large variation in alcohol consumption, alcohol consumption was not an independent risk factor for lung cancer except for current smokers. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/18493860/Alcohol_and_risk_of_lung_cancer_among_Japanese_men:_data_from_a_large_scale_population_based_cohort_study_the_JPHC_study_ L2 - https://doi.org/10.1007/s10552-008-9173-2 DB - PRIME DP - Unbound Medicine ER -