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The risk of chikungunya fever in a dengue-endemic area.
J Travel Med. 2008 May-Jun; 15(3):147-55.JT

Abstract

BACKGROUND

Chikungunya, an alphavirus of the Togaviridae family, causes a febrile disease transmitted to humans by the bite of infected Aedes mosquitoes. This infection is reaching endemic levels in many Southeast Asian countries. Symptoms include sudden onset of fever, chills, headache, nausea, vomiting, joint pain with or without swelling, low back pain, and rash. According to the World Health Organization, there are 2 billion people living in Aedes-infested areas. In addition, traveling to these areas is popular, making the potential risk of infections transmitted by the bite of infected Aedes mosquitoes very high.

METHODS

We proposed a mathematical model to estimate the risk of acquiring chikungunya fever in an Aedes-infested area by taking the prevalence of dengue fever into account. The basic reproduction number for chikungunya fever R(0chik) can be written as a function of the basic reproduction number of dengue R(0dengue) by calculating the ratio R(0chik)/R(0dengue). From R(0chik), we estimated the force of infection and the risk of acquiring the disease both for local residents of a dengue-endemic area and for travelers to this area.

RESULTS

We calculated that R(0chik) is 64.4% that of R(0dengue). The model was applied to a hypothetical situation, namely, estimating the individual risk of acquiring chikungunya fever in a dengue-endemic area, both for local inhabitants (22% in steady state) and for visiting travelers (from 0.31% to 1.23% depending on the time spent in the area).

CONCLUSIONS

The method proposed based on the output of a dynamical model is innovative and provided an estimation of the risk of infection, both for local inhabitants and for visiting travelers.

Authors+Show Affiliations

School of Medicine, University of São Paulo, LIM 01-HCFMUSP, São Paulo, Brazil. edmassad@usp.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18494691

Citation

Massad, Eduardo, et al. "The Risk of Chikungunya Fever in a Dengue-endemic Area." Journal of Travel Medicine, vol. 15, no. 3, 2008, pp. 147-55.
Massad E, Ma S, Burattini MN, et al. The risk of chikungunya fever in a dengue-endemic area. J Travel Med. 2008;15(3):147-55.
Massad, E., Ma, S., Burattini, M. N., Tun, Y., Coutinho, F. A., & Ang, L. W. (2008). The risk of chikungunya fever in a dengue-endemic area. Journal of Travel Medicine, 15(3), 147-55. https://doi.org/10.1111/j.1708-8305.2008.00186.x
Massad E, et al. The Risk of Chikungunya Fever in a Dengue-endemic Area. J Travel Med. 2008 May-Jun;15(3):147-55. PubMed PMID: 18494691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The risk of chikungunya fever in a dengue-endemic area. AU - Massad,Eduardo, AU - Ma,Stefan, AU - Burattini,Marcelo Nascimento, AU - Tun,Ye, AU - Coutinho,Francisco Antonio Bezerra, AU - Ang,Li Wei, PY - 2008/5/23/pubmed PY - 2008/6/10/medline PY - 2008/5/23/entrez SP - 147 EP - 55 JF - Journal of travel medicine JO - J Travel Med VL - 15 IS - 3 N2 - BACKGROUND: Chikungunya, an alphavirus of the Togaviridae family, causes a febrile disease transmitted to humans by the bite of infected Aedes mosquitoes. This infection is reaching endemic levels in many Southeast Asian countries. Symptoms include sudden onset of fever, chills, headache, nausea, vomiting, joint pain with or without swelling, low back pain, and rash. According to the World Health Organization, there are 2 billion people living in Aedes-infested areas. In addition, traveling to these areas is popular, making the potential risk of infections transmitted by the bite of infected Aedes mosquitoes very high. METHODS: We proposed a mathematical model to estimate the risk of acquiring chikungunya fever in an Aedes-infested area by taking the prevalence of dengue fever into account. The basic reproduction number for chikungunya fever R(0chik) can be written as a function of the basic reproduction number of dengue R(0dengue) by calculating the ratio R(0chik)/R(0dengue). From R(0chik), we estimated the force of infection and the risk of acquiring the disease both for local residents of a dengue-endemic area and for travelers to this area. RESULTS: We calculated that R(0chik) is 64.4% that of R(0dengue). The model was applied to a hypothetical situation, namely, estimating the individual risk of acquiring chikungunya fever in a dengue-endemic area, both for local inhabitants (22% in steady state) and for visiting travelers (from 0.31% to 1.23% depending on the time spent in the area). CONCLUSIONS: The method proposed based on the output of a dynamical model is innovative and provided an estimation of the risk of infection, both for local inhabitants and for visiting travelers. SN - 1708-8305 UR - https://www.unboundmedicine.com/medline/citation/18494691/The_risk_of_chikungunya_fever_in_a_dengue_endemic_area_ L2 - https://academic.oup.com/jtm/article-lookup/doi/10.1111/j.1708-8305.2008.00186.x DB - PRIME DP - Unbound Medicine ER -