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Toona sinensis Roem (Meliaceae) leaf extract alleviates hyperglycemia via altering adipose glucose transporter 4.
Food Chem Toxicol. 2008 Jul; 46(7):2554-60.FC

Abstract

In this study we tested the effects of Toona sinensis leaf extracted with water (TSL1) on alloxan-induced (50 mg/kgBwt, i.v.) diabetic Long-Even rats. Diabetic rats given TS leaf with water (TSL1), with 50% alcohol (TSL3) or with H2O extract (TSL5) showed lower levels of plasma glucose. Normal rats given Glibenclamide (GC) had lower levels of plasma glucose, but TSL1 administration showed no significant effect on plasma glucose. By contrast, TSL1 or GC given to alloxan-induced diabetic rats showed a 40% reduction in plasma glucose compared to diabetic rats. Diabetic rats had lower levels of insulin. Interestingly, TSL1 or GC given to diabetic rats showed improvements in plasma insulin levels. Diabetic rats had lower expressions of glucose transporter 4 (GLUT4) mRNA (RT-PCR) and GLUT4 protein (Western blot) in brown and white adipose tissues; in contrast, diabetic rats given TSL1 or GC showed a significant increase in both GLUT4 mRNA and protein levels. Moreover, the expressions of GLUT4 mRNA in red and white muscles were not significantly different among diabetic rats, diabetic rats given TSL1 or GC, and the normal rats. Compared to diabetic rats, diabetic rats given TSL1 or GC had lower levels of GLUT4 protein in white muscle but not in red muscle. Conclusively, T. sinensis Roem (Meliaceae) leaf possesses the hypoglycemia effect underlying an increment of insulin to mediate the adipose glucose transporter 4 mechanism.

Authors+Show Affiliations

Department of Physiology, Kaoshiung Medical University, Kaoshiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18495317

Citation

Wang, Pei-Hwei, et al. "Toona Sinensis Roem (Meliaceae) Leaf Extract Alleviates Hyperglycemia Via Altering Adipose Glucose Transporter 4." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 46, no. 7, 2008, pp. 2554-60.
Wang PH, Tsai MJ, Hsu CY, et al. Toona sinensis Roem (Meliaceae) leaf extract alleviates hyperglycemia via altering adipose glucose transporter 4. Food Chem Toxicol. 2008;46(7):2554-60.
Wang, P. H., Tsai, M. J., Hsu, C. Y., Wang, C. Y., Hsu, H. K., & Weng, C. F. (2008). Toona sinensis Roem (Meliaceae) leaf extract alleviates hyperglycemia via altering adipose glucose transporter 4. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 46(7), 2554-60. https://doi.org/10.1016/j.fct.2008.04.011
Wang PH, et al. Toona Sinensis Roem (Meliaceae) Leaf Extract Alleviates Hyperglycemia Via Altering Adipose Glucose Transporter 4. Food Chem Toxicol. 2008;46(7):2554-60. PubMed PMID: 18495317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toona sinensis Roem (Meliaceae) leaf extract alleviates hyperglycemia via altering adipose glucose transporter 4. AU - Wang,Pei-Hwei, AU - Tsai,May-Jywan, AU - Hsu,Chia-Yu, AU - Wang,Chia-Yi, AU - Hsu,Hseng-Kuang, AU - Weng,Ching-Feng, Y1 - 2008/04/15/ PY - 2007/11/23/received PY - 2008/02/12/revised PY - 2008/04/09/accepted PY - 2008/5/23/pubmed PY - 2008/8/6/medline PY - 2008/5/23/entrez SP - 2554 EP - 60 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 46 IS - 7 N2 - In this study we tested the effects of Toona sinensis leaf extracted with water (TSL1) on alloxan-induced (50 mg/kgBwt, i.v.) diabetic Long-Even rats. Diabetic rats given TS leaf with water (TSL1), with 50% alcohol (TSL3) or with H2O extract (TSL5) showed lower levels of plasma glucose. Normal rats given Glibenclamide (GC) had lower levels of plasma glucose, but TSL1 administration showed no significant effect on plasma glucose. By contrast, TSL1 or GC given to alloxan-induced diabetic rats showed a 40% reduction in plasma glucose compared to diabetic rats. Diabetic rats had lower levels of insulin. Interestingly, TSL1 or GC given to diabetic rats showed improvements in plasma insulin levels. Diabetic rats had lower expressions of glucose transporter 4 (GLUT4) mRNA (RT-PCR) and GLUT4 protein (Western blot) in brown and white adipose tissues; in contrast, diabetic rats given TSL1 or GC showed a significant increase in both GLUT4 mRNA and protein levels. Moreover, the expressions of GLUT4 mRNA in red and white muscles were not significantly different among diabetic rats, diabetic rats given TSL1 or GC, and the normal rats. Compared to diabetic rats, diabetic rats given TSL1 or GC had lower levels of GLUT4 protein in white muscle but not in red muscle. Conclusively, T. sinensis Roem (Meliaceae) leaf possesses the hypoglycemia effect underlying an increment of insulin to mediate the adipose glucose transporter 4 mechanism. SN - 0278-6915 UR - https://www.unboundmedicine.com/medline/citation/18495317/Toona_sinensis_Roem__Meliaceae__leaf_extract_alleviates_hyperglycemia_via_altering_adipose_glucose_transporter_4_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(08)00185-3 DB - PRIME DP - Unbound Medicine ER -