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The cardiovascular implications of alcohol and red wine.

Abstract

We reviewed the roles of both alcohol and red wine in cardiovascular disease by discussing key animal and human studies. Included are studies regarding alcohol's association with coronary heart disease and the proposed mechanisms of action of alcohol. Likewise, studies concerning red wine's cardiovascular benefit and the mechanisms of action of red wine are discussed. Lastly, we reviewed studies on the adverse effects of alcohol and the current consumption recommendations as stated by the American Heart Association. Moderate alcohol consumption (<or=2 drinks per day) is associated with a reduced risk of coronary heart disease. This is believed to occur through alcohol's antithrombotic properties and its ability to increase high-density lipoprotein levels. It remains unclear whether polyphenol compounds in red wine make it an especially cardioprotective alcoholic beverage. These compounds are proposed to act by inhibiting low-density lipoprotein oxidation and thrombosis independently of alcohol. Moderate alcohol consumption is not associated with any significant morbidity; however, three or more drinks per day is associated with hypertriglyceridemia, cardiomyopathy, hypertension, and stroke. The American Heart Association does not recommend alcohol as a treatment approach and suggests that men drink no more than two drinks per day and women no more than one drink per day.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, Chicago Medical School, North Chicago, IL 60064, USA.

    Source

    MeSH

    Alcohol Drinking
    American Heart Association
    Animals
    Cardiovascular Diseases
    Clinical Trials as Topic
    Disease Models, Animal
    Ethanol
    Female
    Humans
    Male
    United States
    Wine

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    18496264

    Citation

    Saremi, Adonis, and Rohit Arora. "The Cardiovascular Implications of Alcohol and Red Wine." American Journal of Therapeutics, vol. 15, no. 3, 2008, pp. 265-77.
    Saremi A, Arora R. The cardiovascular implications of alcohol and red wine. Am J Ther. 2008;15(3):265-77.
    Saremi, A., & Arora, R. (2008). The cardiovascular implications of alcohol and red wine. American Journal of Therapeutics, 15(3), pp. 265-77. doi:10.1097/MJT.0b013e3180a5e61a.
    Saremi A, Arora R. The Cardiovascular Implications of Alcohol and Red Wine. Am J Ther. 2008;15(3):265-77. PubMed PMID: 18496264.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The cardiovascular implications of alcohol and red wine. AU - Saremi,Adonis, AU - Arora,Rohit, PY - 2008/5/23/pubmed PY - 2008/7/2/medline PY - 2008/5/23/entrez SP - 265 EP - 77 JF - American journal of therapeutics JO - Am J Ther VL - 15 IS - 3 N2 - We reviewed the roles of both alcohol and red wine in cardiovascular disease by discussing key animal and human studies. Included are studies regarding alcohol's association with coronary heart disease and the proposed mechanisms of action of alcohol. Likewise, studies concerning red wine's cardiovascular benefit and the mechanisms of action of red wine are discussed. Lastly, we reviewed studies on the adverse effects of alcohol and the current consumption recommendations as stated by the American Heart Association. Moderate alcohol consumption (<or=2 drinks per day) is associated with a reduced risk of coronary heart disease. This is believed to occur through alcohol's antithrombotic properties and its ability to increase high-density lipoprotein levels. It remains unclear whether polyphenol compounds in red wine make it an especially cardioprotective alcoholic beverage. These compounds are proposed to act by inhibiting low-density lipoprotein oxidation and thrombosis independently of alcohol. Moderate alcohol consumption is not associated with any significant morbidity; however, three or more drinks per day is associated with hypertriglyceridemia, cardiomyopathy, hypertension, and stroke. The American Heart Association does not recommend alcohol as a treatment approach and suggests that men drink no more than two drinks per day and women no more than one drink per day. SN - 1536-3686 UR - https://www.unboundmedicine.com/medline/citation/18496264/The_cardiovascular_implications_of_alcohol_and_red_wine_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=18496264.ui DB - PRIME DP - Unbound Medicine ER -