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Serum vitamin D and subsequent occurrence of type 2 diabetes.
Epidemiology. 2008 Sep; 19(5):666-71.E

Abstract

BACKGROUND

Low vitamin D status has been suggested as a risk factor for type 2 diabetes. Although the epidemiologic evidence is scarce, 2 recent studies have suggested an association. The present study investigated the relation of serum vitamin D with type 2 diabetes incidence using pooled data from these 2 cohorts.

METHODS

Two nested case-control studies, collected by the Finnish Mobile Clinic in 1973-1980, were pooled for analysis. The study populations consisted of men and women aged 40-74 years and free of diabetes at baseline. During a follow-up period of 22 years, 412 incident type 2 diabetes cases occurred, and 986 controls were selected by individual matching. Serum vitamin D (serum 25(OH)D) was determined from frozen samples, stored at baseline. Pooled estimates of the relationship between serum vitamin D concentration and type 2 diabetes incidence were calculated.

RESULTS

Men had higher serum vitamin D concentrations than women and showed a reduced risk of type 2 diabetes in their highest vitamin D quartile. The relative odds between the highest and lowest quartiles was 0.28 (95% confidence interval = 0.10-0.81) in men and 1.14 (0.60-2.17) in women after adjustment for smoking, body mass index, physical activity, and education.

CONCLUSIONS

The results support the hypothesis that high vitamin D status provides protection against type 2 diabetes. Residual confounding may contribute to this association.

Authors+Show Affiliations

National Public Health Institute, Department of Health and Functional Capacity, Mannerheimintie 166, 00300 Helsinki, Finland. paul.knekt@ktl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18496468

Citation

Knekt, Paul, et al. "Serum Vitamin D and Subsequent Occurrence of Type 2 Diabetes." Epidemiology (Cambridge, Mass.), vol. 19, no. 5, 2008, pp. 666-71.
Knekt P, Laaksonen M, Mattila C, et al. Serum vitamin D and subsequent occurrence of type 2 diabetes. Epidemiology. 2008;19(5):666-71.
Knekt, P., Laaksonen, M., Mattila, C., Härkänen, T., Marniemi, J., Heliövaara, M., Rissanen, H., Montonen, J., & Reunanen, A. (2008). Serum vitamin D and subsequent occurrence of type 2 diabetes. Epidemiology (Cambridge, Mass.), 19(5), 666-71. https://doi.org/10.1097/EDE.0b013e318176b8ad
Knekt P, et al. Serum Vitamin D and Subsequent Occurrence of Type 2 Diabetes. Epidemiology. 2008;19(5):666-71. PubMed PMID: 18496468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum vitamin D and subsequent occurrence of type 2 diabetes. AU - Knekt,Paul, AU - Laaksonen,Maarit, AU - Mattila,Catharina, AU - Härkänen,Tommi, AU - Marniemi,Jukka, AU - Heliövaara,Markku, AU - Rissanen,Harri, AU - Montonen,Jukka, AU - Reunanen,Antti, PY - 2008/5/23/pubmed PY - 2008/9/3/medline PY - 2008/5/23/entrez SP - 666 EP - 71 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 19 IS - 5 N2 - BACKGROUND: Low vitamin D status has been suggested as a risk factor for type 2 diabetes. Although the epidemiologic evidence is scarce, 2 recent studies have suggested an association. The present study investigated the relation of serum vitamin D with type 2 diabetes incidence using pooled data from these 2 cohorts. METHODS: Two nested case-control studies, collected by the Finnish Mobile Clinic in 1973-1980, were pooled for analysis. The study populations consisted of men and women aged 40-74 years and free of diabetes at baseline. During a follow-up period of 22 years, 412 incident type 2 diabetes cases occurred, and 986 controls were selected by individual matching. Serum vitamin D (serum 25(OH)D) was determined from frozen samples, stored at baseline. Pooled estimates of the relationship between serum vitamin D concentration and type 2 diabetes incidence were calculated. RESULTS: Men had higher serum vitamin D concentrations than women and showed a reduced risk of type 2 diabetes in their highest vitamin D quartile. The relative odds between the highest and lowest quartiles was 0.28 (95% confidence interval = 0.10-0.81) in men and 1.14 (0.60-2.17) in women after adjustment for smoking, body mass index, physical activity, and education. CONCLUSIONS: The results support the hypothesis that high vitamin D status provides protection against type 2 diabetes. Residual confounding may contribute to this association. SN - 1531-5487 UR - https://www.unboundmedicine.com/medline/citation/18496468/Serum_vitamin_D_and_subsequent_occurrence_of_type_2_diabetes_ L2 - https://doi.org/10.1097/EDE.0b013e318176b8ad DB - PRIME DP - Unbound Medicine ER -