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Evaluation of preterm births and birth defects in liveborn infants of US military women who received smallpox vaccine.
Birth Defects Res A Clin Mol Teratol. 2008 Jul; 82(7):533-9.BD

Abstract

BACKGROUND

Women serving in the US military have some unique occupational exposures, including exposure to vaccinations that are rarely required in civilian professions. When vaccinations are inadvertently given during pregnancy, such exposures raise special concerns. These analyses address health outcomes, particularly preterm births and birth defects, among infants who appear to have been exposed to maternal smallpox vaccination in pregnancy.

METHODS

This retrospective cohort study included 31,420 infants born to active-duty military women during 2003-2004. We used Department of Defense databases to define maternal vaccination and infant health outcomes. Multivariable regression models were developed to describe associations between maternal smallpox vaccination and preterm births and birth defects in liveborn infants.

RESULTS

There were 7,735 infants identified as born to women ever vaccinated against smallpox, and 672 infants born to women vaccinated in the first trimester of pregnancy. In multivariable modeling, maternal smallpox vaccination in pregnancy was not associated with preterm or extreme preterm delivery. Maternal smallpox vaccination in the first trimester of pregnancy was not significantly associated with overall birth defects (OR 1.40; 95% CI: 0.94, 2.07), or any of seven specific defects individually modeled.

CONCLUSIONS

Results may be reassuring that smallpox vaccine, when inadvertently administered to pregnant women, is not associated with preterm delivery or birth defects in liveborn infants.

Authors+Show Affiliations

US Department of Defense Center for Deployment Health Research, Naval Health Research Center, San Diego, California 92106, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18496830

Citation

Ryan, Margaret A K., et al. "Evaluation of Preterm Births and Birth Defects in Liveborn Infants of US Military Women Who Received Smallpox Vaccine." Birth Defects Research. Part A, Clinical and Molecular Teratology, vol. 82, no. 7, 2008, pp. 533-9.
Ryan MA, Gumbs GR, Conlin AM, et al. Evaluation of preterm births and birth defects in liveborn infants of US military women who received smallpox vaccine. Birth Defects Res A Clin Mol Teratol. 2008;82(7):533-9.
Ryan, M. A., Gumbs, G. R., Conlin, A. M., Sevick, C. J., Jacobson, I. G., Snell, K. J., Spooner, C. N., & Smith, T. C. (2008). Evaluation of preterm births and birth defects in liveborn infants of US military women who received smallpox vaccine. Birth Defects Research. Part A, Clinical and Molecular Teratology, 82(7), 533-9. https://doi.org/10.1002/bdra.20470
Ryan MA, et al. Evaluation of Preterm Births and Birth Defects in Liveborn Infants of US Military Women Who Received Smallpox Vaccine. Birth Defects Res A Clin Mol Teratol. 2008;82(7):533-9. PubMed PMID: 18496830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of preterm births and birth defects in liveborn infants of US military women who received smallpox vaccine. AU - Ryan,Margaret A K, AU - Gumbs,Gia R, AU - Conlin,Ava Marie S, AU - Sevick,Carter J, AU - Jacobson,Isabel G, AU - Snell,Katherine J, AU - Spooner,Christina N, AU - Smith,Tyler C, AU - ,, PY - 2008/5/23/pubmed PY - 2008/8/12/medline PY - 2008/5/23/entrez SP - 533 EP - 9 JF - Birth defects research. Part A, Clinical and molecular teratology JO - Birth Defects Res A Clin Mol Teratol VL - 82 IS - 7 N2 - BACKGROUND: Women serving in the US military have some unique occupational exposures, including exposure to vaccinations that are rarely required in civilian professions. When vaccinations are inadvertently given during pregnancy, such exposures raise special concerns. These analyses address health outcomes, particularly preterm births and birth defects, among infants who appear to have been exposed to maternal smallpox vaccination in pregnancy. METHODS: This retrospective cohort study included 31,420 infants born to active-duty military women during 2003-2004. We used Department of Defense databases to define maternal vaccination and infant health outcomes. Multivariable regression models were developed to describe associations between maternal smallpox vaccination and preterm births and birth defects in liveborn infants. RESULTS: There were 7,735 infants identified as born to women ever vaccinated against smallpox, and 672 infants born to women vaccinated in the first trimester of pregnancy. In multivariable modeling, maternal smallpox vaccination in pregnancy was not associated with preterm or extreme preterm delivery. Maternal smallpox vaccination in the first trimester of pregnancy was not significantly associated with overall birth defects (OR 1.40; 95% CI: 0.94, 2.07), or any of seven specific defects individually modeled. CONCLUSIONS: Results may be reassuring that smallpox vaccine, when inadvertently administered to pregnant women, is not associated with preterm delivery or birth defects in liveborn infants. SN - 1542-0760 UR - https://www.unboundmedicine.com/medline/citation/18496830/Evaluation_of_preterm_births_and_birth_defects_in_liveborn_infants_of_US_military_women_who_received_smallpox_vaccine_ L2 - https://doi.org/10.1002/bdra.20470 DB - PRIME DP - Unbound Medicine ER -