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The physiology of vitamin D : current concepts.
Indian J Med Res. 2008 Mar; 127(3):256-62.IJ

Abstract

The vitamin D endocrine system, besides playing pivotal roles in calcium homeostasis & bone mineral metabolism, is now recognized to subserve a wide range of fundamental biological functions in cell differentiation, inhibition of cell growth as well as immuno modulation. Vitamin D is a prohormone which is converted into its active hormonal form 1, 25 (OH)D2 D, 1, 25 (OH)D2 D activates its cellular receptor (VDR) which activate target genes to engender its biological actions. This review provides a summary of recent understanding of the complex actions of the vitamin D hormone 1, 25 (OH)2 D which is a final product of 1alpha hydroxylation in the proximal tubular cells of kidneys. Emerging evidence also indicates both 1, 25 (OH)2 D3 independent as well as depended action of vitamin D receptor (VDR). Thus, the vitamin D system action may involve more than one single receptor and legand. The presence of 1alpha hydroxylase in many target cells other than proximal renal tubular cells indicates autocrine and paracrine functions for 1, 25 (OH)2 D3 in the control of cell proliferation and differentiation. Vitamin D and related molecules belong to a elaborate endocrine system that acts on target genomic receptors in several organ systems to control cell proliferation and differentiation.

Authors+Show Affiliations

M.S. Ramaiah Medical College & Hospitals, Bangalore, India. kochupillai@gmail.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18497440

Citation

Kochupillai, N. "The Physiology of Vitamin D : Current Concepts." The Indian Journal of Medical Research, vol. 127, no. 3, 2008, pp. 256-62.
Kochupillai N. The physiology of vitamin D : current concepts. Indian J Med Res. 2008;127(3):256-62.
Kochupillai, N. (2008). The physiology of vitamin D : current concepts. The Indian Journal of Medical Research, 127(3), 256-62.
Kochupillai N. The Physiology of Vitamin D : Current Concepts. Indian J Med Res. 2008;127(3):256-62. PubMed PMID: 18497440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The physiology of vitamin D : current concepts. A1 - Kochupillai,N, PY - 2008/5/24/pubmed PY - 2008/9/16/medline PY - 2008/5/24/entrez SP - 256 EP - 62 JF - The Indian journal of medical research JO - Indian J. Med. Res. VL - 127 IS - 3 N2 - The vitamin D endocrine system, besides playing pivotal roles in calcium homeostasis & bone mineral metabolism, is now recognized to subserve a wide range of fundamental biological functions in cell differentiation, inhibition of cell growth as well as immuno modulation. Vitamin D is a prohormone which is converted into its active hormonal form 1, 25 (OH)D2 D, 1, 25 (OH)D2 D activates its cellular receptor (VDR) which activate target genes to engender its biological actions. This review provides a summary of recent understanding of the complex actions of the vitamin D hormone 1, 25 (OH)2 D which is a final product of 1alpha hydroxylation in the proximal tubular cells of kidneys. Emerging evidence also indicates both 1, 25 (OH)2 D3 independent as well as depended action of vitamin D receptor (VDR). Thus, the vitamin D system action may involve more than one single receptor and legand. The presence of 1alpha hydroxylase in many target cells other than proximal renal tubular cells indicates autocrine and paracrine functions for 1, 25 (OH)2 D3 in the control of cell proliferation and differentiation. Vitamin D and related molecules belong to a elaborate endocrine system that acts on target genomic receptors in several organ systems to control cell proliferation and differentiation. SN - 0971-5916 UR - https://www.unboundmedicine.com/medline/citation/18497440/The_physiology_of_vitamin_D_:_current_concepts_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -
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