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Highlighting the immunohistochemical profile of melanocytomas: review.
Oncol Rep 2008; 19(6):1367-72OR

Abstract

The histological assessment of atypical melanocytic neoplasms is mandatory to ensure proper diagnosis and treatment. However, for some atypical lesions, expert pathologists report only moderate concordance in the diagnosis. In addition, certain atypical neoplasms have been coined differently in the literature. These designations include among others atypical and metastasizing Spitz tumor, malignant Spitz naevus, borderline and intermediate melanocytic tumor, and melanocytic tumor of uncertain malignant potential (MELTUMP) or Spitzoid melanocytic tumor of uncertain malignant potential (STUMP). These neoplasms are grouped here under the heading melanocytoma. Such melanocytic lesions have a benign outcome but exhibit an atypical and worrisome aspect. Rare individual cases of melanocytomas can progress to locoregional disease (agminate melanocytomas), and even beyond. At times, the distinction between melanocytoma and melanoma is difficult and may even be impossible. However, multipronged immunohistochemistry can help define malignancy risk stratification and therapeutic guidelines.

Authors+Show Affiliations

Department of Dermatopathology, University Hospital of Liège, Liège, Belgium.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18497938

Citation

Quatresooz, Pascale, et al. "Highlighting the Immunohistochemical Profile of Melanocytomas: Review." Oncology Reports, vol. 19, no. 6, 2008, pp. 1367-72.
Quatresooz P, Piérard-Franchimont C, Piérard GE. Highlighting the immunohistochemical profile of melanocytomas: review. Oncol Rep. 2008;19(6):1367-72.
Quatresooz, P., Piérard-Franchimont, C., & Piérard, G. E. (2008). Highlighting the immunohistochemical profile of melanocytomas: review. Oncology Reports, 19(6), pp. 1367-72.
Quatresooz P, Piérard-Franchimont C, Piérard GE. Highlighting the Immunohistochemical Profile of Melanocytomas: Review. Oncol Rep. 2008;19(6):1367-72. PubMed PMID: 18497938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Highlighting the immunohistochemical profile of melanocytomas: review. AU - Quatresooz,Pascale, AU - Piérard-Franchimont,Claudine, AU - Piérard,Gérald E, PY - 2008/5/24/pubmed PY - 2008/8/8/medline PY - 2008/5/24/entrez SP - 1367 EP - 72 JF - Oncology reports JO - Oncol. Rep. VL - 19 IS - 6 N2 - The histological assessment of atypical melanocytic neoplasms is mandatory to ensure proper diagnosis and treatment. However, for some atypical lesions, expert pathologists report only moderate concordance in the diagnosis. In addition, certain atypical neoplasms have been coined differently in the literature. These designations include among others atypical and metastasizing Spitz tumor, malignant Spitz naevus, borderline and intermediate melanocytic tumor, and melanocytic tumor of uncertain malignant potential (MELTUMP) or Spitzoid melanocytic tumor of uncertain malignant potential (STUMP). These neoplasms are grouped here under the heading melanocytoma. Such melanocytic lesions have a benign outcome but exhibit an atypical and worrisome aspect. Rare individual cases of melanocytomas can progress to locoregional disease (agminate melanocytomas), and even beyond. At times, the distinction between melanocytoma and melanoma is difficult and may even be impossible. However, multipronged immunohistochemistry can help define malignancy risk stratification and therapeutic guidelines. SN - 1021-335X UR - https://www.unboundmedicine.com/medline/citation/18497938/Highlighting_the_immunohistochemical_profile_of_melanocytomas:_review_ L2 - http://www.spandidos-publications.com/or/19/6/1367 DB - PRIME DP - Unbound Medicine ER -