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Overview of the clinical problem: facts and current issues of mucinous cystic neoplasms of the pancreas.
Dig Liver Dis. 2008 Nov; 40(11):837-46.DL

Abstract

Pancreatic cystic lesions are uncommon and consist of pseudocysts, congenital cysts and cystic neoplasms including mucinous cystic neoplasms, intraductal papillary mucinous neoplasms and serous cystic neoplasms. Mucinous cystic neoplasms are large septated cysts without connection to the ductal system, characterised by the presence of thick-walled ovarian-type stroma and mucin. They occur predominantly in women and often are malignant. Therefore, surgical resection is recommended. Intraductal papillary mucinous neoplasms are neoplasms with tall, columnar, mucin-containing epithelium involving the main pancreatic ducts or major side branches. Intraductal papillary mucinous neoplasms occur in men and women in their 60s and 70s and may differentiate into malignant neoplasms. Therefore, surgical resection is mandatory. Serous cystic neoplasms appear as multiple cysts lined with cubic flat epithelium containing glycogen-rich cells with clear cytoplasm. They mainly occur in women in their 50s and are generally benign. Therefore, a conservative approach is recommended. As both mucinous cystic neoplasm and intraductal papillary mucinous neoplasms have a high malignant potential, it is important to differentiate between the various pancreatic cystic lesions. Several imaging techniques and tumour markers have been evaluated. Nonetheless, definitive guidelines to differentiate between serous cystic neoplasms, mucinous cystic neoplasms and intraductal papillary mucinous neoplasms are still poorly defined. A number of management issues regarding these neoplasms are still under debate, for example which imaging technique to use, differentiation between malignant or benign lesions and the preferred treatment modality for each pancreatic cystic neoplasm. Further research may lead to a definitive guideline for the diagnosis and treatment of mucinous cystic neoplasms, intraductal papillary mucinous neoplasms and serous cystic neoplasms.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Centre Rotterdam, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18499541

Citation

Jeurnink, S M., et al. "Overview of the Clinical Problem: Facts and Current Issues of Mucinous Cystic Neoplasms of the Pancreas." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 40, no. 11, 2008, pp. 837-46.
Jeurnink SM, Vleggaar FP, Siersema PD. Overview of the clinical problem: facts and current issues of mucinous cystic neoplasms of the pancreas. Dig Liver Dis. 2008;40(11):837-46.
Jeurnink, S. M., Vleggaar, F. P., & Siersema, P. D. (2008). Overview of the clinical problem: facts and current issues of mucinous cystic neoplasms of the pancreas. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 40(11), 837-46. https://doi.org/10.1016/j.dld.2008.03.018
Jeurnink SM, Vleggaar FP, Siersema PD. Overview of the Clinical Problem: Facts and Current Issues of Mucinous Cystic Neoplasms of the Pancreas. Dig Liver Dis. 2008;40(11):837-46. PubMed PMID: 18499541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overview of the clinical problem: facts and current issues of mucinous cystic neoplasms of the pancreas. AU - Jeurnink,S M, AU - Vleggaar,F P, AU - Siersema,P D, Y1 - 2008/05/22/ PY - 2008/02/29/received PY - 2008/03/31/accepted PY - 2008/5/24/pubmed PY - 2009/1/16/medline PY - 2008/5/24/entrez SP - 837 EP - 46 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 40 IS - 11 N2 - Pancreatic cystic lesions are uncommon and consist of pseudocysts, congenital cysts and cystic neoplasms including mucinous cystic neoplasms, intraductal papillary mucinous neoplasms and serous cystic neoplasms. Mucinous cystic neoplasms are large septated cysts without connection to the ductal system, characterised by the presence of thick-walled ovarian-type stroma and mucin. They occur predominantly in women and often are malignant. Therefore, surgical resection is recommended. Intraductal papillary mucinous neoplasms are neoplasms with tall, columnar, mucin-containing epithelium involving the main pancreatic ducts or major side branches. Intraductal papillary mucinous neoplasms occur in men and women in their 60s and 70s and may differentiate into malignant neoplasms. Therefore, surgical resection is mandatory. Serous cystic neoplasms appear as multiple cysts lined with cubic flat epithelium containing glycogen-rich cells with clear cytoplasm. They mainly occur in women in their 50s and are generally benign. Therefore, a conservative approach is recommended. As both mucinous cystic neoplasm and intraductal papillary mucinous neoplasms have a high malignant potential, it is important to differentiate between the various pancreatic cystic lesions. Several imaging techniques and tumour markers have been evaluated. Nonetheless, definitive guidelines to differentiate between serous cystic neoplasms, mucinous cystic neoplasms and intraductal papillary mucinous neoplasms are still poorly defined. A number of management issues regarding these neoplasms are still under debate, for example which imaging technique to use, differentiation between malignant or benign lesions and the preferred treatment modality for each pancreatic cystic neoplasm. Further research may lead to a definitive guideline for the diagnosis and treatment of mucinous cystic neoplasms, intraductal papillary mucinous neoplasms and serous cystic neoplasms. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/18499541/Overview_of_the_clinical_problem:_facts_and_current_issues_of_mucinous_cystic_neoplasms_of_the_pancreas_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(08)00150-3 DB - PRIME DP - Unbound Medicine ER -