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Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study.

Abstract

BACKGROUND

Many patients have preoperative anxiety; therefore, the development of a strong anxiolytic with minimal psychomotor impairment for premedication may be desirable.

METHODS

In this study, 60 patients were randomized into two groups to receive either oral Passiflora incarnata (500 mg, Passipy IranDarouk) (n = 30) or placebo (n = 30) as premedication, 90 min before surgery. A numerical rating scale (NRS) was used for each patient to assess anxiety and sedation before, and 10, 30, 60, and 90 min after premedication. Psychomotor function was assessed with the Trieger Dot Test and the Digit-Symbol Substitution Test at arrival in the operating room, 30 and 90 min after tracheal extubation. The time interval between arrival in the postanesthesia care unit and discharge to home (discharge time) was recorded for each patient.

RESULTS

The demographic characteristics of patients, ASA physical status, duration of surgery, basal NRS score, sedation at the preset time intervals, and discharge time were similar in the two groups. The NRS anxiety scores were significantly lower in the passiflora group than in the control group (P < 0.001). There were no significant differences in psychological variables in the postanesthesia care unit and recovery of psychomotor function was comparable in both groups.

CONCLUSIONS

In outpatient surgery, administration of oral Passiflora incarnata as a premedication reduces anxiety without inducing sedation.

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  • Authors+Show Affiliations

    ,

    Department of Anesthesiology and Critical Care, Dr Ali Shariati Hospital, North Karegar St., Tehran, Iran. movafegh@sina.tums.ac.ir

    , , ,

    Source

    Anesthesia and analgesia 106:6 2008 Jun pg 1728-32

    MeSH

    Administration, Oral
    Adult
    Ambulatory Surgical Procedures
    Anesthesia Recovery Period
    Anti-Anxiety Agents
    Anxiety
    Consciousness
    Double-Blind Method
    Female
    Humans
    Male
    Passiflora
    Patient Discharge
    Plant Extracts
    Preanesthetic Medication
    Psychomotor Performance
    Time Factors
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    18499602

    Citation

    Movafegh, Ali, et al. "Preoperative Oral Passiflora Incarnata Reduces Anxiety in Ambulatory Surgery Patients: a Double-blind, Placebo-controlled Study." Anesthesia and Analgesia, vol. 106, no. 6, 2008, pp. 1728-32.
    Movafegh A, Alizadeh R, Hajimohamadi F, et al. Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. Anesth Analg. 2008;106(6):1728-32.
    Movafegh, A., Alizadeh, R., Hajimohamadi, F., Esfehani, F., & Nejatfar, M. (2008). Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. Anesthesia and Analgesia, 106(6), pp. 1728-32. doi:10.1213/ane.0b013e318172c3f9.
    Movafegh A, et al. Preoperative Oral Passiflora Incarnata Reduces Anxiety in Ambulatory Surgery Patients: a Double-blind, Placebo-controlled Study. Anesth Analg. 2008;106(6):1728-32. PubMed PMID: 18499602.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. AU - Movafegh,Ali, AU - Alizadeh,Reza, AU - Hajimohamadi,Fatimah, AU - Esfehani,Fatimah, AU - Nejatfar,Mohmad, PY - 2008/5/24/pubmed PY - 2008/6/6/medline PY - 2008/5/24/entrez SP - 1728 EP - 32 JF - Anesthesia and analgesia JO - Anesth. Analg. VL - 106 IS - 6 N2 - BACKGROUND: Many patients have preoperative anxiety; therefore, the development of a strong anxiolytic with minimal psychomotor impairment for premedication may be desirable. METHODS: In this study, 60 patients were randomized into two groups to receive either oral Passiflora incarnata (500 mg, Passipy IranDarouk) (n = 30) or placebo (n = 30) as premedication, 90 min before surgery. A numerical rating scale (NRS) was used for each patient to assess anxiety and sedation before, and 10, 30, 60, and 90 min after premedication. Psychomotor function was assessed with the Trieger Dot Test and the Digit-Symbol Substitution Test at arrival in the operating room, 30 and 90 min after tracheal extubation. The time interval between arrival in the postanesthesia care unit and discharge to home (discharge time) was recorded for each patient. RESULTS: The demographic characteristics of patients, ASA physical status, duration of surgery, basal NRS score, sedation at the preset time intervals, and discharge time were similar in the two groups. The NRS anxiety scores were significantly lower in the passiflora group than in the control group (P < 0.001). There were no significant differences in psychological variables in the postanesthesia care unit and recovery of psychomotor function was comparable in both groups. CONCLUSIONS: In outpatient surgery, administration of oral Passiflora incarnata as a premedication reduces anxiety without inducing sedation. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/18499602/Preoperative_oral_Passiflora_incarnata_reduces_anxiety_in_ambulatory_surgery_patients:_a_double_blind_placebo_controlled_study_ L2 - http://Insights.ovid.com/pubmed?pmid=18499602 DB - PRIME DP - Unbound Medicine ER -