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Ewing sarcoma and primitive neuroectodermal tumor of the esophagus: report of a case and review of literature.
Int J Surg Pathol. 2010 Oct; 18(5):388-93.IJ

Abstract

This study presents a case of Ewing sarcoma and primitive neuroectodermal tumor arising in the esophagus of a 44-year-old woman who presented with progressive dysphagia. Imaging studies demonstrated a polypoid lesion in the esophagus. The tumor was characterized by corded and pseudopapillary architecture, cytologic monotony, and low proliferative activity. Immunohistochemical stains were positive for CD99, neuron-specific enolase, vimentin, cyclin D1, p53, and FLI1 gene product. Fluorescence in situ hybridization demonstrated a 22q12 translocation, associated with primitive neuroectodermal tumor in the tumor cells, whereas reverse transcription polymerase chain reaction conformed expression of Ewing sarcoma/FLI1 fusion transcript in the patient's bone marrow aspirate. Although this is a rare site for this type of tumor to occur, primitive neuroectodermal tumor should be considered in the differential diagnosis of mesenchymal tumors of the esophagus. Genetic analysis is crucial to establish the diagnosis and can be successfully performed on formalin-fixed, paraffin-embedded material and hematopoietic tissue.

Authors+Show Affiliations

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

18499684

Citation

Johnson, Andrew D., et al. "Ewing Sarcoma and Primitive Neuroectodermal Tumor of the Esophagus: Report of a Case and Review of Literature." International Journal of Surgical Pathology, vol. 18, no. 5, 2010, pp. 388-93.
Johnson AD, Pambuccian SE, Andrade RS, et al. Ewing sarcoma and primitive neuroectodermal tumor of the esophagus: report of a case and review of literature. Int J Surg Pathol. 2010;18(5):388-93.
Johnson, A. D., Pambuccian, S. E., Andrade, R. S., Dolan, M. M., & Aslan, D. L. (2010). Ewing sarcoma and primitive neuroectodermal tumor of the esophagus: report of a case and review of literature. International Journal of Surgical Pathology, 18(5), 388-93. https://doi.org/10.1177/1066896908316903
Johnson AD, et al. Ewing Sarcoma and Primitive Neuroectodermal Tumor of the Esophagus: Report of a Case and Review of Literature. Int J Surg Pathol. 2010;18(5):388-93. PubMed PMID: 18499684.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ewing sarcoma and primitive neuroectodermal tumor of the esophagus: report of a case and review of literature. AU - Johnson,Andrew D, AU - Pambuccian,Stefan E, AU - Andrade,Rafael S, AU - Dolan,Michelle M, AU - Aslan,Deniz L, Y1 - 2008/05/21/ PY - 2008/5/24/pubmed PY - 2011/2/23/medline PY - 2008/5/24/entrez SP - 388 EP - 93 JF - International journal of surgical pathology JO - Int. J. Surg. Pathol. VL - 18 IS - 5 N2 - This study presents a case of Ewing sarcoma and primitive neuroectodermal tumor arising in the esophagus of a 44-year-old woman who presented with progressive dysphagia. Imaging studies demonstrated a polypoid lesion in the esophagus. The tumor was characterized by corded and pseudopapillary architecture, cytologic monotony, and low proliferative activity. Immunohistochemical stains were positive for CD99, neuron-specific enolase, vimentin, cyclin D1, p53, and FLI1 gene product. Fluorescence in situ hybridization demonstrated a 22q12 translocation, associated with primitive neuroectodermal tumor in the tumor cells, whereas reverse transcription polymerase chain reaction conformed expression of Ewing sarcoma/FLI1 fusion transcript in the patient's bone marrow aspirate. Although this is a rare site for this type of tumor to occur, primitive neuroectodermal tumor should be considered in the differential diagnosis of mesenchymal tumors of the esophagus. Genetic analysis is crucial to establish the diagnosis and can be successfully performed on formalin-fixed, paraffin-embedded material and hematopoietic tissue. SN - 1940-2465 UR - https://www.unboundmedicine.com/medline/citation/18499684/Ewing_sarcoma_and_primitive_neuroectodermal_tumor_of_the_esophagus:_report_of_a_case_and_review_of_literature_ L2 - http://journals.sagepub.com/doi/full/10.1177/1066896908316903?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -