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Synchronous primary perianal Paget's disease and rectal adenocarcinoma: report of a hitherto undescribed phenomenon.
Int J Surg Pathol 2009; 17(1):42-5IJ

Abstract

Perianal Paget's disease is rare. It usually represents intraepidermal extension of an invasive carcinoma from an adjacent internal organ, but some cases represent primary intraepithelial cutaneous apocrine adenocarcinomas. Here, we report a unique case, which we interpret as synchronous primary perianal Paget's disease and lower rectal adenocarcinoma. Immunohistochemical stains demonstrated that the Paget's cells were CK7+/ CK20-/GCDFP+, whereas the rectal adenocarcinoma was CK7+(variable)/CK20+/GCDFP-. This discordant immunoprofile supported our impression that the Paget's disease in this patient was of cutaneous apocrine origin rather than a pagetoid extension from the patient's nearby rectal adenocarcinoma-to our knowledge a hitherto undocumented occurrence.

Authors+Show Affiliations

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.No affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18499687

Citation

Chanjuan Shi, , and Pedram Argani. "Synchronous Primary Perianal Paget's Disease and Rectal Adenocarcinoma: Report of a Hitherto Undescribed Phenomenon." International Journal of Surgical Pathology, vol. 17, no. 1, 2009, pp. 42-5.
Chanjuan Shi , Argani P. Synchronous primary perianal Paget's disease and rectal adenocarcinoma: report of a hitherto undescribed phenomenon. Int J Surg Pathol. 2009;17(1):42-5.
Chanjuan Shi, ., & Argani, P. (2009). Synchronous primary perianal Paget's disease and rectal adenocarcinoma: report of a hitherto undescribed phenomenon. International Journal of Surgical Pathology, 17(1), pp. 42-5. doi:10.1177/1066896908316069.
Chanjuan Shi , Argani P. Synchronous Primary Perianal Paget's Disease and Rectal Adenocarcinoma: Report of a Hitherto Undescribed Phenomenon. Int J Surg Pathol. 2009;17(1):42-5. PubMed PMID: 18499687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synchronous primary perianal Paget's disease and rectal adenocarcinoma: report of a hitherto undescribed phenomenon. AU - Chanjuan Shi,, AU - Argani,Pedram, Y1 - 2008/05/21/ PY - 2008/5/24/pubmed PY - 2009/3/25/medline PY - 2008/5/24/entrez SP - 42 EP - 5 JF - International journal of surgical pathology JO - Int. J. Surg. Pathol. VL - 17 IS - 1 N2 - Perianal Paget's disease is rare. It usually represents intraepidermal extension of an invasive carcinoma from an adjacent internal organ, but some cases represent primary intraepithelial cutaneous apocrine adenocarcinomas. Here, we report a unique case, which we interpret as synchronous primary perianal Paget's disease and lower rectal adenocarcinoma. Immunohistochemical stains demonstrated that the Paget's cells were CK7+/ CK20-/GCDFP+, whereas the rectal adenocarcinoma was CK7+(variable)/CK20+/GCDFP-. This discordant immunoprofile supported our impression that the Paget's disease in this patient was of cutaneous apocrine origin rather than a pagetoid extension from the patient's nearby rectal adenocarcinoma-to our knowledge a hitherto undocumented occurrence. SN - 1066-8969 UR - https://www.unboundmedicine.com/medline/citation/18499687/Synchronous_primary_perianal_Paget's_disease_and_rectal_adenocarcinoma:_report_of_a_hitherto_undescribed_phenomenon_ L2 - http://journals.sagepub.com/doi/full/10.1177/1066896908316069?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -