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Variables influencing drug release from layered matrix system comprising hydroxypropyl methylcellulose.
AAPS PharmSciTech. 2008; 9(2):668-74.AP

Abstract

The purpose of this study was to prepare and evaluate layered matrix tablets of propranolol HCl containing HPMC and phytowax as matrix component using direct compression technique. Layering with this polymeric matrix could prolong the release of drug and shift the release pattern approach to zero order as described from the least square curve fitting. Increasing the amount of coating layer could apparently prolong the drug release. The longer lag time of drug release from one planar apparently when the amount of coating layer was increased. HPMC concentration and compression force did not affect the drug release from this three-layer tablet. The drug release from this three-layer tablet was influenced by hydrodynamic force. An increase in stirring rate was a corresponding increasing in the release rate. From photoimage and SEM, gel mass of HPMC was increased with time during dissolution and covered the core surface, therefore dissolved drug molecules were allowed to diffuse out from the core through the polymer network of gel layer containing the porous structure. This suggested that HPMC and phytowax could be fabricated into the layered matrix tablet exhibiting sustained drug release.

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Authors+Show Affiliations

Phaechamud T
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand, thawatchaienator@gmail.com.

MeSH

Adrenergic beta-AntagonistsChemistry, PharmaceuticalDelayed-Action PreparationsDiffusionDrug CarriersDrug CompoundingHardnessHydrogen-Ion ConcentrationHypromellose DerivativesKineticsMethylcelluloseMicroscopy, Electron, ScanningModels, ChemicalOlive OilPlant OilsPorosityPropranololSolubilitySurface PropertiesTechnology, Pharmaceutical

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18500559

Citation

Phaechamud, Thawatchai. "Variables Influencing Drug Release From Layered Matrix System Comprising Hydroxypropyl Methylcellulose." AAPS PharmSciTech, vol. 9, no. 2, 2008, pp. 668-74.
Phaechamud T. Variables influencing drug release from layered matrix system comprising hydroxypropyl methylcellulose. AAPS PharmSciTech. 2008;9(2):668-74.
Phaechamud, T. (2008). Variables influencing drug release from layered matrix system comprising hydroxypropyl methylcellulose. AAPS PharmSciTech, 9(2), 668-74. https://doi.org/10.1208/s12249-008-9085-1
Phaechamud T. Variables Influencing Drug Release From Layered Matrix System Comprising Hydroxypropyl Methylcellulose. AAPS PharmSciTech. 2008;9(2):668-74. PubMed PMID: 18500559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variables influencing drug release from layered matrix system comprising hydroxypropyl methylcellulose. A1 - Phaechamud,Thawatchai, Y1 - 2008/05/24/ PY - 2007/10/23/received PY - 2008/02/25/accepted PY - 2008/5/27/pubmed PY - 2008/9/16/medline PY - 2008/5/27/entrez SP - 668 EP - 74 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 9 IS - 2 N2 - The purpose of this study was to prepare and evaluate layered matrix tablets of propranolol HCl containing HPMC and phytowax as matrix component using direct compression technique. Layering with this polymeric matrix could prolong the release of drug and shift the release pattern approach to zero order as described from the least square curve fitting. Increasing the amount of coating layer could apparently prolong the drug release. The longer lag time of drug release from one planar apparently when the amount of coating layer was increased. HPMC concentration and compression force did not affect the drug release from this three-layer tablet. The drug release from this three-layer tablet was influenced by hydrodynamic force. An increase in stirring rate was a corresponding increasing in the release rate. From photoimage and SEM, gel mass of HPMC was increased with time during dissolution and covered the core surface, therefore dissolved drug molecules were allowed to diffuse out from the core through the polymer network of gel layer containing the porous structure. This suggested that HPMC and phytowax could be fabricated into the layered matrix tablet exhibiting sustained drug release. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/18500559/Variables_influencing_drug_release_from_layered_matrix_system_comprising_hydroxypropyl_methylcellulose_ L2 - https://dx.doi.org/10.1208/s12249-008-9085-1 DB - PRIME DP - Unbound Medicine ER -