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High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study.
BMC Public Health 2008; 8:176BP

Abstract

BACKGROUND

To estimate the prevalence of diagnosed and undiagnosed diabetes mellitus, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and combined IFG/IGT in a large urban Iranian population aged > or = 20 years.

METHODS

The study population included 9,489 participants of the Tehran Lipid and Glucose Study with full relevant clinical data. Age-standardized prevalence of diabetes and glucose intolerance categories were reported according to the 2003 American Diabetes Association definitions. Age-adjusted logistic regression models were used to estimate the numbers needed to screen (NNTS) to find one person with undiagnosed diabetes.

RESULTS

The prevalence of diagnosed and undiagnosed diabetes, isolated IFG, isolated IGT, and combined IFG/IGT were 8.1%, 5.1%, 8.7%, 5.4% and 4.0% in men and 10%, 4.7%, 6.3%, 7.6%, and 4.5% in women respectively. Participants with undiagnosed diabetes had higher age, body mass index (BMI), waist circumference, systolic and diastolic blood pressures, triglycerides (all p values <0.001) and lower HDL-cholesterol (only in women, p < 0.01) compared to normoglycemic subjects. Undiagnosed diabetes was associated with family history of diabetes, increased BMI (> or = 25 kg/m2), abdominal obesity, hypertriglyceridemia, hypertension and low HDL-cholesterol levels. Among men, a combination of increased BMI, hypertension, and family history of diabetes led to a NNTS of 1.6 (95% CI: 1.57-1.71) and among women a combination of family history of diabetes and abdominal obesity, yielded a NNTS of 2.2 (95% CI: 2.1-2.4).

CONCLUSION

In conclusion, about one third of Tehranian adults had disturbed glucose tolerance or diabetes. One- third of total cases with diabetes were undiagnosed. Screening individuals with BMI > or = 25 kg/m2 (men), hypertension (men), abdominal obesity (women) and family history of diabetes may be more efficient.

Authors+Show Affiliations

Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (M.C), Tehran, Iran. fzhadaegh@endocrine.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18501007

Citation

Hadaegh, Farzad, et al. "High Prevalence of Undiagnosed Diabetes and Abnormal Glucose Tolerance in the Iranian Urban Population: Tehran Lipid and Glucose Study." BMC Public Health, vol. 8, 2008, p. 176.
Hadaegh F, Bozorgmanesh MR, Ghasemi A, et al. High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study. BMC Public Health. 2008;8:176.
Hadaegh, F., Bozorgmanesh, M. R., Ghasemi, A., Harati, H., Saadat, N., & Azizi, F. (2008). High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study. BMC Public Health, 8, p. 176. doi:10.1186/1471-2458-8-176.
Hadaegh F, et al. High Prevalence of Undiagnosed Diabetes and Abnormal Glucose Tolerance in the Iranian Urban Population: Tehran Lipid and Glucose Study. BMC Public Health. 2008 May 24;8:176. PubMed PMID: 18501007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High prevalence of undiagnosed diabetes and abnormal glucose tolerance in the Iranian urban population: Tehran Lipid and Glucose Study. AU - Hadaegh,Farzad, AU - Bozorgmanesh,Mohammad Reza, AU - Ghasemi,Asghar, AU - Harati,Hadi, AU - Saadat,Navid, AU - Azizi,Fereidoun, Y1 - 2008/05/24/ PY - 2007/12/10/received PY - 2008/05/24/accepted PY - 2008/5/27/pubmed PY - 2008/9/3/medline PY - 2008/5/27/entrez SP - 176 EP - 176 JF - BMC public health JO - BMC Public Health VL - 8 N2 - BACKGROUND: To estimate the prevalence of diagnosed and undiagnosed diabetes mellitus, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and combined IFG/IGT in a large urban Iranian population aged > or = 20 years. METHODS: The study population included 9,489 participants of the Tehran Lipid and Glucose Study with full relevant clinical data. Age-standardized prevalence of diabetes and glucose intolerance categories were reported according to the 2003 American Diabetes Association definitions. Age-adjusted logistic regression models were used to estimate the numbers needed to screen (NNTS) to find one person with undiagnosed diabetes. RESULTS: The prevalence of diagnosed and undiagnosed diabetes, isolated IFG, isolated IGT, and combined IFG/IGT were 8.1%, 5.1%, 8.7%, 5.4% and 4.0% in men and 10%, 4.7%, 6.3%, 7.6%, and 4.5% in women respectively. Participants with undiagnosed diabetes had higher age, body mass index (BMI), waist circumference, systolic and diastolic blood pressures, triglycerides (all p values <0.001) and lower HDL-cholesterol (only in women, p < 0.01) compared to normoglycemic subjects. Undiagnosed diabetes was associated with family history of diabetes, increased BMI (> or = 25 kg/m2), abdominal obesity, hypertriglyceridemia, hypertension and low HDL-cholesterol levels. Among men, a combination of increased BMI, hypertension, and family history of diabetes led to a NNTS of 1.6 (95% CI: 1.57-1.71) and among women a combination of family history of diabetes and abdominal obesity, yielded a NNTS of 2.2 (95% CI: 2.1-2.4). CONCLUSION: In conclusion, about one third of Tehranian adults had disturbed glucose tolerance or diabetes. One- third of total cases with diabetes were undiagnosed. Screening individuals with BMI > or = 25 kg/m2 (men), hypertension (men), abdominal obesity (women) and family history of diabetes may be more efficient. SN - 1471-2458 UR - https://www.unboundmedicine.com/medline/citation/18501007/High_prevalence_of_undiagnosed_diabetes_and_abnormal_glucose_tolerance_in_the_Iranian_urban_population:_Tehran_Lipid_and_Glucose_Study_ L2 - https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-8-176 DB - PRIME DP - Unbound Medicine ER -