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Somatic comorbidities of irritable bowel syndrome: a systematic analysis.
J Psychosom Res. 2008 Jun; 64(6):573-82.JP

Abstract

OBJECTIVE

A large number of irritable bowel syndrome (IBS) patients are additionally afflicted with other somatic intestinal and/or extraintestinal comorbidities. The occurrence of one or more comorbidities is correlated with enhanced medical help seeking, worse prognosis, and higher rates of anxiety and depression-all resulting in a reduced quality of life. The aims of this study were, firstly, to review the literature on comorbidities of IBS and to assess gastrointestinal and extraintestinal comorbidities, and, secondly, to evaluate explanatory hypotheses and possible common pathophysiological mechanisms.

METHODS

We systematically reviewed the scientific literature in the past 25 years, as cited in MEDLINE.

RESULTS

IBS patients present with a twofold increase in somatic comorbidities compared to controls, possibly caused by common pathophysiological mechanisms. Nevertheless, to date, there has been no convincing evidence for a consolidated underlying pathophysiology or somatization. Gastrointestinal disorders, such as functional dyspepsia, gastroesophageal reflux disease, functional constipation, and anal incontinence, occur in almost half of the patients. In a broad variety of extraintestinal comorbidities, fibromyalgia, chronic fatigue syndrome, and chronic pelvic pain are best documented and appear in up to 65%.

CONCLUSION

The knowledge and structured assessment of comorbid somatic symptoms might allow to identify subgroups of IBS patients with special characteristics and lead to adaptation of the therapeutic concept.

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Authors+Show Affiliations

Riedl A
Division of Hepatology, Gastroenterology, and Endocrinology, Department of Medicine, Charité-University Medical Center, Campus Virchow, Berlin, Germany.
Schmidtmann M
No affiliation info available
Stengel A
No affiliation info available
Goebel M
No affiliation info available
Wisser AS
No affiliation info available
Klapp BF
No affiliation info available
Mönnikes H
No affiliation info available

MeSH

ComorbidityDiagnosis, DifferentialFatigue Syndrome, ChronicFemaleFemale Urogenital DiseasesHumansIrritable Bowel SyndromeMaleMale Urogenital DiseasesMigraine DisordersMusculoskeletal DiseasesPainSomatoform Disorders

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18501257

Clinical Trial Links

The Effect of Shigyakusan Used for IBS and MUPS Diagnosed by Abdominal N Line Tenderness

Citation

Riedl, Andrea, et al. "Somatic Comorbidities of Irritable Bowel Syndrome: a Systematic Analysis." Journal of Psychosomatic Research, vol. 64, no. 6, 2008, pp. 573-82.
Riedl A, Schmidtmann M, Stengel A, et al. Somatic comorbidities of irritable bowel syndrome: a systematic analysis. J Psychosom Res. 2008;64(6):573-82.
Riedl, A., Schmidtmann, M., Stengel, A., Goebel, M., Wisser, A. S., Klapp, B. F., & Mönnikes, H. (2008). Somatic comorbidities of irritable bowel syndrome: a systematic analysis. Journal of Psychosomatic Research, 64(6), 573-82. https://doi.org/10.1016/j.jpsychores.2008.02.021
Riedl A, et al. Somatic Comorbidities of Irritable Bowel Syndrome: a Systematic Analysis. J Psychosom Res. 2008;64(6):573-82. PubMed PMID: 18501257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Somatic comorbidities of irritable bowel syndrome: a systematic analysis. AU - Riedl,Andrea, AU - Schmidtmann,Marco, AU - Stengel,Andreas, AU - Goebel,Miriam, AU - Wisser,Anna-Sophia, AU - Klapp,Burghard F, AU - Mönnikes,Hubert, Y1 - 2008/04/28/ PY - 2007/09/03/received PY - 2008/02/05/revised PY - 2008/02/07/accepted PY - 2008/5/27/pubmed PY - 2008/10/22/medline PY - 2008/5/27/entrez SP - 573 EP - 82 JF - Journal of psychosomatic research JO - J Psychosom Res VL - 64 IS - 6 N2 - OBJECTIVE: A large number of irritable bowel syndrome (IBS) patients are additionally afflicted with other somatic intestinal and/or extraintestinal comorbidities. The occurrence of one or more comorbidities is correlated with enhanced medical help seeking, worse prognosis, and higher rates of anxiety and depression-all resulting in a reduced quality of life. The aims of this study were, firstly, to review the literature on comorbidities of IBS and to assess gastrointestinal and extraintestinal comorbidities, and, secondly, to evaluate explanatory hypotheses and possible common pathophysiological mechanisms. METHODS: We systematically reviewed the scientific literature in the past 25 years, as cited in MEDLINE. RESULTS: IBS patients present with a twofold increase in somatic comorbidities compared to controls, possibly caused by common pathophysiological mechanisms. Nevertheless, to date, there has been no convincing evidence for a consolidated underlying pathophysiology or somatization. Gastrointestinal disorders, such as functional dyspepsia, gastroesophageal reflux disease, functional constipation, and anal incontinence, occur in almost half of the patients. In a broad variety of extraintestinal comorbidities, fibromyalgia, chronic fatigue syndrome, and chronic pelvic pain are best documented and appear in up to 65%. CONCLUSION: The knowledge and structured assessment of comorbid somatic symptoms might allow to identify subgroups of IBS patients with special characteristics and lead to adaptation of the therapeutic concept. SN - 0022-3999 UR - https://www.unboundmedicine.com/medline/citation/18501257/Somatic_comorbidities_of_irritable_bowel_syndrome:_a_systematic_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3999(08)00061-5 DB - PRIME DP - Unbound Medicine ER -