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Letrozole co-treatment in infertile women 40 years old and older receiving controlled ovarian stimulation and intrauterine insemination.
Fertil Steril. 2009 Jun; 91(6):2501-7.FS

Abstract

OBJECTIVE

To investigate the effect of a combination of letrozole and gonadotropins in advanced reproductive age infertile women who were treated with IUI.

DESIGN

A retrospective case control study.

SETTING

A private practice affiliated with an academic institute.

PATIENT(S)

Infertile women 40 years old and older who were treated with IUI and controlled ovarian hyperstimulation (COH) using either letrozole in combination with FSH (n = 90) or FSH alone (n = 69).

MAIN OUTCOME MEASURE(S)

Pregnancy rates (PR), mature follicles, serum levels of E(2), P, LH, endometrial thickness, rates of cycle cancellation, and FSH dose.

RESULT(S)

Pregnancy rates were comparable between the letrozole-FSH co-treatment group and the FSH alone group. Significantly fewer cycles were cancelled in the letrozole co-treatment group. The E(2) levels and the number of follicles were significantly higher in the FSH-only group. Serum levels of LH were significantly higher in the co-treatment group on cycle day 7. The P levels were significantly higher in the FSH alone group on the day of hCG administration.

CONCLUSION(S)

Letrozole co-treatment compared with using FSH alone has significantly modified the cycle characteristics without reducing PRs and could be of potential benefit in IUI cycles in older infertile women.

Authors+Show Affiliations

Toronto Centre For Advanced Reproductive Technologies (TCART), and Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18501899

Citation

Bedaiwy, Mohamed A., et al. "Letrozole Co-treatment in Infertile Women 40 Years Old and Older Receiving Controlled Ovarian Stimulation and Intrauterine Insemination." Fertility and Sterility, vol. 91, no. 6, 2009, pp. 2501-7.
Bedaiwy MA, Shokry M, Mousa N, et al. Letrozole co-treatment in infertile women 40 years old and older receiving controlled ovarian stimulation and intrauterine insemination. Fertil Steril. 2009;91(6):2501-7.
Bedaiwy, M. A., Shokry, M., Mousa, N., Claessens, A., Esfandiari, N., Gotleib, L., & Casper, R. (2009). Letrozole co-treatment in infertile women 40 years old and older receiving controlled ovarian stimulation and intrauterine insemination. Fertility and Sterility, 91(6), 2501-7. https://doi.org/10.1016/j.fertnstert.2008.03.020
Bedaiwy MA, et al. Letrozole Co-treatment in Infertile Women 40 Years Old and Older Receiving Controlled Ovarian Stimulation and Intrauterine Insemination. Fertil Steril. 2009;91(6):2501-7. PubMed PMID: 18501899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Letrozole co-treatment in infertile women 40 years old and older receiving controlled ovarian stimulation and intrauterine insemination. AU - Bedaiwy,Mohamed A, AU - Shokry,Mahmoud, AU - Mousa,Noha, AU - Claessens,Anne, AU - Esfandiari,Navid, AU - Gotleib,Lynda, AU - Casper,Robert, Y1 - 2008/05/23/ PY - 2007/08/16/received PY - 2008/02/03/revised PY - 2008/03/07/accepted PY - 2008/5/27/pubmed PY - 2009/7/9/medline PY - 2008/5/27/entrez SP - 2501 EP - 7 JF - Fertility and sterility JO - Fertil. Steril. VL - 91 IS - 6 N2 - OBJECTIVE: To investigate the effect of a combination of letrozole and gonadotropins in advanced reproductive age infertile women who were treated with IUI. DESIGN: A retrospective case control study. SETTING: A private practice affiliated with an academic institute. PATIENT(S): Infertile women 40 years old and older who were treated with IUI and controlled ovarian hyperstimulation (COH) using either letrozole in combination with FSH (n = 90) or FSH alone (n = 69). MAIN OUTCOME MEASURE(S): Pregnancy rates (PR), mature follicles, serum levels of E(2), P, LH, endometrial thickness, rates of cycle cancellation, and FSH dose. RESULT(S): Pregnancy rates were comparable between the letrozole-FSH co-treatment group and the FSH alone group. Significantly fewer cycles were cancelled in the letrozole co-treatment group. The E(2) levels and the number of follicles were significantly higher in the FSH-only group. Serum levels of LH were significantly higher in the co-treatment group on cycle day 7. The P levels were significantly higher in the FSH alone group on the day of hCG administration. CONCLUSION(S): Letrozole co-treatment compared with using FSH alone has significantly modified the cycle characteristics without reducing PRs and could be of potential benefit in IUI cycles in older infertile women. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18501899/Letrozole_co_treatment_in_infertile_women_40_years_old_and_older_receiving_controlled_ovarian_stimulation_and_intrauterine_insemination_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)00591-8 DB - PRIME DP - Unbound Medicine ER -