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Propionyl-L-carnitine in Leriche-Fontaine stage II peripheral arterial obstructive disease.
Ann Vasc Surg. 2008 Jul-Aug; 22(4):552-8.AV

Abstract

Peripheral arterial obstructive disease (PAOD) of the lower limbs affects 5% of the adult population. Uncontrolled arteriopathy is established due to a microcirculatory deficit, which may be present despite a good Winsor index and which leads to exhaustion of the functional microcirculatory reserve. The target of this study was to examine possible improvements in microvascular and tissue homeostasis by the administration of propionyl-L-carnitine (PLC). A total of 26 patients were enrolled in this study, aged 65 +/- 15 years; two males were diagnosed at stage IIA and 17 males and seven females at stage IIB PAOD. The main criterion of inclusion was the worsening of walking distance during the last month. In this study the duration of therapy was 33 days. PLC was administered in three flasks, each containing 300 mg in 250 cc saline by continuous infusion. The following parameters were measured before and after treatment: pain-free and maximum walking distance (measured on a treadmill at 3.2 km/hr with a gradient of 12%), recovery time from pain after maximum walking distance, ankle-brachial index by means of the Doppler apparatus, and evaluation of the microcirculation using capillaroscopy. The results showed that therapy with PLC was effective at restoring activity of skeletal muscle in ischemic conditions. In particular, capillaroscopy showed improvement in the angioarchitecture in the microcirculation fields, expressed as increased numbers of visible capillaries and diminution in the time of loss of sodium fluorescein marker. The clinical data showed increased walking distance and diminished time to recover from pain, and the clinical improvement correlated with improved microcirculatory function. From these preliminary data has emerged an indication of therapy with PLC for chronic obstructive arteriopathy of the lower limbs at stage II. Further studies with higher numbers of patients and more controlled variables are planned.

Authors+Show Affiliations

San Giovanni Hospital, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18502605

Citation

Allegra, Claudio, et al. "Propionyl-L-carnitine in Leriche-Fontaine Stage II Peripheral Arterial Obstructive Disease." Annals of Vascular Surgery, vol. 22, no. 4, 2008, pp. 552-8.
Allegra C, Antignani PL, Schachter I, et al. Propionyl-L-carnitine in Leriche-Fontaine stage II peripheral arterial obstructive disease. Ann Vasc Surg. 2008;22(4):552-8.
Allegra, C., Antignani, P. L., Schachter, I., Koverech, A., Messano, M., & Virmani, A. (2008). Propionyl-L-carnitine in Leriche-Fontaine stage II peripheral arterial obstructive disease. Annals of Vascular Surgery, 22(4), 552-8. https://doi.org/10.1016/j.avsg.2008.02.010
Allegra C, et al. Propionyl-L-carnitine in Leriche-Fontaine Stage II Peripheral Arterial Obstructive Disease. Ann Vasc Surg. 2008 Jul-Aug;22(4):552-8. PubMed PMID: 18502605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Propionyl-L-carnitine in Leriche-Fontaine stage II peripheral arterial obstructive disease. AU - Allegra,Claudio, AU - Antignani,Pier Luigi, AU - Schachter,Ilana, AU - Koverech,Aleardo, AU - Messano,Masa, AU - Virmani,Ashraf, Y1 - 2008/05/27/ PY - 2007/04/23/received PY - 2008/02/01/revised PY - 2008/02/13/accepted PY - 2008/5/27/pubmed PY - 2008/9/18/medline PY - 2008/5/27/entrez SP - 552 EP - 8 JF - Annals of vascular surgery JO - Ann Vasc Surg VL - 22 IS - 4 N2 - Peripheral arterial obstructive disease (PAOD) of the lower limbs affects 5% of the adult population. Uncontrolled arteriopathy is established due to a microcirculatory deficit, which may be present despite a good Winsor index and which leads to exhaustion of the functional microcirculatory reserve. The target of this study was to examine possible improvements in microvascular and tissue homeostasis by the administration of propionyl-L-carnitine (PLC). A total of 26 patients were enrolled in this study, aged 65 +/- 15 years; two males were diagnosed at stage IIA and 17 males and seven females at stage IIB PAOD. The main criterion of inclusion was the worsening of walking distance during the last month. In this study the duration of therapy was 33 days. PLC was administered in three flasks, each containing 300 mg in 250 cc saline by continuous infusion. The following parameters were measured before and after treatment: pain-free and maximum walking distance (measured on a treadmill at 3.2 km/hr with a gradient of 12%), recovery time from pain after maximum walking distance, ankle-brachial index by means of the Doppler apparatus, and evaluation of the microcirculation using capillaroscopy. The results showed that therapy with PLC was effective at restoring activity of skeletal muscle in ischemic conditions. In particular, capillaroscopy showed improvement in the angioarchitecture in the microcirculation fields, expressed as increased numbers of visible capillaries and diminution in the time of loss of sodium fluorescein marker. The clinical data showed increased walking distance and diminished time to recover from pain, and the clinical improvement correlated with improved microcirculatory function. From these preliminary data has emerged an indication of therapy with PLC for chronic obstructive arteriopathy of the lower limbs at stage II. Further studies with higher numbers of patients and more controlled variables are planned. SN - 1615-5947 UR - https://www.unboundmedicine.com/medline/citation/18502605/Propionyl_L_carnitine_in_Leriche_Fontaine_stage_II_peripheral_arterial_obstructive_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-5096(08)00085-X DB - PRIME DP - Unbound Medicine ER -