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The effects of areca catechu L extract on anti-inflammation and anti-melanogenesis.
Int J Cosmet Sci. 1999 Aug; 21(4):275-84.IJ

Abstract

Ethanolic extract (CC-516) from Areca catechu L was prepared and its various biological activities were evaluated, CC-516 showed potent anti-oxidative, free radical scavenging, and anti-hyaluronidase activity. Anti-oxidative effect of CC-516 (IC _ 50: 45.4 mug/ml) was lower than butylated hydroxytoluene (IC _ 50: 5mug ml), but similar to tocopherol and higher than ascorbic acid. Especially, CC-516 exhibited relatively high free radical scavenging activity (IC _ 50: 10.2 mug/ml) compared to control. CC-516 inhibited effectively hyaluronidase activity (IC _ 50: 416 mug/ml), showed inhibition in vivo on delayed hypersensitivity as well as croton-oil induced ear edema in mice when it was topically applied. These results strongly suggest that CC-516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC-516 showed anti-allergic and anti-cytotoxicity activity. The whitening effect of CC-516 shown by the inhibition of mushroom tyrosinase activity with IC _ 50 of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. This study indicates that CC-516 is effective on anti-inflammatory/anti-melanogenesis, and can be used as a new agent for cosmetics.

Authors+Show Affiliations

Department of Biochemistry, College of Natural Science, Chungbuk National University, Cheongju, Chungbuk, 361-763, South Korea.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18503445

Citation

Lee, K K., and J D. Choi. "The Effects of Areca Catechu L Extract On Anti-inflammation and Anti-melanogenesis." International Journal of Cosmetic Science, vol. 21, no. 4, 1999, pp. 275-84.
Lee KK, Choi JD. The effects of areca catechu L extract on anti-inflammation and anti-melanogenesis. Int J Cosmet Sci. 1999;21(4):275-84.
Lee, K. K., & Choi, J. D. (1999). The effects of areca catechu L extract on anti-inflammation and anti-melanogenesis. International Journal of Cosmetic Science, 21(4), 275-84. https://doi.org/10.1046/j.1467-2494.1999.196590.x
Lee KK, Choi JD. The Effects of Areca Catechu L Extract On Anti-inflammation and Anti-melanogenesis. Int J Cosmet Sci. 1999;21(4):275-84. PubMed PMID: 18503445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of areca catechu L extract on anti-inflammation and anti-melanogenesis. AU - Lee,K K, AU - Choi,J D, PY - 2008/5/28/pubmed PY - 2008/5/28/medline PY - 2008/5/28/entrez SP - 275 EP - 84 JF - International journal of cosmetic science JO - Int J Cosmet Sci VL - 21 IS - 4 N2 - Ethanolic extract (CC-516) from Areca catechu L was prepared and its various biological activities were evaluated, CC-516 showed potent anti-oxidative, free radical scavenging, and anti-hyaluronidase activity. Anti-oxidative effect of CC-516 (IC _ 50: 45.4 mug/ml) was lower than butylated hydroxytoluene (IC _ 50: 5mug ml), but similar to tocopherol and higher than ascorbic acid. Especially, CC-516 exhibited relatively high free radical scavenging activity (IC _ 50: 10.2 mug/ml) compared to control. CC-516 inhibited effectively hyaluronidase activity (IC _ 50: 416 mug/ml), showed inhibition in vivo on delayed hypersensitivity as well as croton-oil induced ear edema in mice when it was topically applied. These results strongly suggest that CC-516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC-516 showed anti-allergic and anti-cytotoxicity activity. The whitening effect of CC-516 shown by the inhibition of mushroom tyrosinase activity with IC _ 50 of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. This study indicates that CC-516 is effective on anti-inflammatory/anti-melanogenesis, and can be used as a new agent for cosmetics. SN - 0142-5463 UR - https://www.unboundmedicine.com/medline/citation/18503445/The_effects_of_areca_catechu_L_extract_on_anti_inflammation_and_anti_melanogenesis_ L2 - https://doi.org/10.1046/j.1467-2494.1999.196590.x DB - PRIME DP - Unbound Medicine ER -
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