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Microchimerism decades after transfusion among combat-injured US veterans from the Vietnam, Korean, and World War II conflicts.
Transfusion. 2008 Aug; 48(8):1609-15.T

Abstract

BACKGROUND

Blood transfusion after traumatic injury can result in microchimerism (MC) of donor white cells (WBCs) in the recipient as late as 2 to 3 years postinjury, the longest prospective follow-up to date. The purpose of this study was to determine how long transfusion-associated MC lasts after traumatic injury.

STUDY DESIGN AND METHODS

A group of US combat veterans who received transfusions who responded to a recruitment notice was retrospectively evaluated. Their blood was sampled, and MC was assessed by quantitative allele-specific polymerase chain reaction detection of differences at the HLA-DR locus or a panel of insertion-deletion polymorphism loci. Results of veterans were compared to those from an age- and gender-matched blood donor control group, from whom WBCs were retrieved from leukoreduction filters.

RESULTS

Among 163 combat veterans who received transfusion and 150 control subjects who did not receive transfusions, 16 (9.8%) of the veterans and 1 (0.7%) control subject had evidence of MC (relative risk, 14.7; 95% confidence interval, 2.0-110). The veterans with MC included 3 who served in WWII (7% of subjects from that conflict), 5 in Korea (18%), and 6 in Vietnam (7%).

CONCLUSIONS

Transfusion for combat-related injury can result in MC that lasts for 60 years, suggesting that it may involve permanent engraftment. MC is rare among male blood donors who did not receive transfusions, who are probably representative of individuals who have not had postnatal allogeneic exposures.

Authors+Show Affiliations

Department of Surgery, University of California, Davis, Medical Center, Sacramento, California 95817, USA. garth.utter@ucdmc.ucdavis.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18503616

Citation

Utter, Garth H., et al. "Microchimerism Decades After Transfusion Among Combat-injured US Veterans From the Vietnam, Korean, and World War II Conflicts." Transfusion, vol. 48, no. 8, 2008, pp. 1609-15.
Utter GH, Lee TH, Rivers RM, et al. Microchimerism decades after transfusion among combat-injured US veterans from the Vietnam, Korean, and World War II conflicts. Transfusion. 2008;48(8):1609-15.
Utter, G. H., Lee, T. H., Rivers, R. M., Montalvo, L., Wen, L., Chafets, D. M., Reed, W. F., & Busch, M. P. (2008). Microchimerism decades after transfusion among combat-injured US veterans from the Vietnam, Korean, and World War II conflicts. Transfusion, 48(8), 1609-15. https://doi.org/10.1111/j.1537-2995.2008.01758.x
Utter GH, et al. Microchimerism Decades After Transfusion Among Combat-injured US Veterans From the Vietnam, Korean, and World War II Conflicts. Transfusion. 2008;48(8):1609-15. PubMed PMID: 18503616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microchimerism decades after transfusion among combat-injured US veterans from the Vietnam, Korean, and World War II conflicts. AU - Utter,Garth H, AU - Lee,Tzong-Hae, AU - Rivers,Ryan M, AU - Montalvo,Lani, AU - Wen,Li, AU - Chafets,Daniel M, AU - Reed,William F, AU - Busch,Michael P, Y1 - 2008/05/22/ PY - 2008/5/28/pubmed PY - 2008/10/1/medline PY - 2008/5/28/entrez SP - 1609 EP - 15 JF - Transfusion JO - Transfusion VL - 48 IS - 8 N2 - BACKGROUND: Blood transfusion after traumatic injury can result in microchimerism (MC) of donor white cells (WBCs) in the recipient as late as 2 to 3 years postinjury, the longest prospective follow-up to date. The purpose of this study was to determine how long transfusion-associated MC lasts after traumatic injury. STUDY DESIGN AND METHODS: A group of US combat veterans who received transfusions who responded to a recruitment notice was retrospectively evaluated. Their blood was sampled, and MC was assessed by quantitative allele-specific polymerase chain reaction detection of differences at the HLA-DR locus or a panel of insertion-deletion polymorphism loci. Results of veterans were compared to those from an age- and gender-matched blood donor control group, from whom WBCs were retrieved from leukoreduction filters. RESULTS: Among 163 combat veterans who received transfusion and 150 control subjects who did not receive transfusions, 16 (9.8%) of the veterans and 1 (0.7%) control subject had evidence of MC (relative risk, 14.7; 95% confidence interval, 2.0-110). The veterans with MC included 3 who served in WWII (7% of subjects from that conflict), 5 in Korea (18%), and 6 in Vietnam (7%). CONCLUSIONS: Transfusion for combat-related injury can result in MC that lasts for 60 years, suggesting that it may involve permanent engraftment. MC is rare among male blood donors who did not receive transfusions, who are probably representative of individuals who have not had postnatal allogeneic exposures. SN - 0041-1132 UR - https://www.unboundmedicine.com/medline/citation/18503616/Microchimerism_decades_after_transfusion_among_combat_injured_US_veterans_from_the_Vietnam_Korean_and_World_War_II_conflicts_ L2 - https://doi.org/10.1111/j.1537-2995.2008.01758.x DB - PRIME DP - Unbound Medicine ER -