Tags

Type your tag names separated by a space and hit enter

CT perfusion mapping of hemodynamic disturbances associated to acute spontaneous intracerebral hemorrhage.
Neuroradiology. 2008 Aug; 50(8):729-40.N

Abstract

INTRODUCTION

We sought to quantify perfusion changes associated to acute spontaneous intracerebral hemorrhage (SICH) by means of computed tomography perfusion (CTP) imaging.

MATERIALS AND METHODS

We studied 89 patients with supratentorial SICH at admission CT by using CTP scanning obtained within 24 h after symptom onset. Regional cerebral blood flow (rCBF), cerebral blood volume (rCBV) and mean transit time (rMTT) levels were measured in four different regions of interest manually outlined on CT scan: (1) hemorrhagic core; (2) perihematomal low-density area; (3) 1 cm rim of normal-appearing brain tissue surrounding the perilesional area; and (4) a mirrored area, including the clot and the perihematomal region, located in the non-lesioned contralateral hemisphere.

RESULTS

rCBF, rCBV, and rMTT mean levels showed a centrifugal distribution with a gradual increase from the core to the periphery (p < 0.0001). Perfusion absolute values were indicative of ischemia in hemorrhagic core, oligemia in perihematomal area, and hyperemia in normal-appearing and contralateral areas. Perihematomal rCBF and rCBV mean levels were higher in small (< or = 20 ml) than in large (>20 ml) hematomas (p < 0.01 and p < 0.02, respectively).

CONCLUSION

Multi-parametric CTP mapping of acute SICH indicates that perfusion values show a progressive improvement from the core to the periphery. In the first 24 h, perihemorrhagic region was hypoperfused with CTP values which were not suggestive of ischemic penumbra destined to survive but more likely indicative of edema formation. These findings also argue for a potential influence of early amounts of bleeding on perihematomal hemodynamic abnormalities.

Authors+Show Affiliations

Neuroradiology Unit, Department of Neuroscience, Azienda Ospedaliera Universitaria, Arcispedale S. Anna, Corso della Giovecca 203, 44100, Ferrara, Italy. henryfai@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18504564

Citation

Fainardi, Enrico, et al. "CT Perfusion Mapping of Hemodynamic Disturbances Associated to Acute Spontaneous Intracerebral Hemorrhage." Neuroradiology, vol. 50, no. 8, 2008, pp. 729-40.
Fainardi E, Borrelli M, Saletti A, et al. CT perfusion mapping of hemodynamic disturbances associated to acute spontaneous intracerebral hemorrhage. Neuroradiology. 2008;50(8):729-40.
Fainardi, E., Borrelli, M., Saletti, A., Schivalocchi, R., Azzini, C., Cavallo, M., Ceruti, S., Tamarozzi, R., & Chieregato, A. (2008). CT perfusion mapping of hemodynamic disturbances associated to acute spontaneous intracerebral hemorrhage. Neuroradiology, 50(8), 729-40. https://doi.org/10.1007/s00234-008-0402-x
Fainardi E, et al. CT Perfusion Mapping of Hemodynamic Disturbances Associated to Acute Spontaneous Intracerebral Hemorrhage. Neuroradiology. 2008;50(8):729-40. PubMed PMID: 18504564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CT perfusion mapping of hemodynamic disturbances associated to acute spontaneous intracerebral hemorrhage. AU - Fainardi,Enrico, AU - Borrelli,Massimo, AU - Saletti,Andrea, AU - Schivalocchi,Roberta, AU - Azzini,Cristiano, AU - Cavallo,Michele, AU - Ceruti,Stefano, AU - Tamarozzi,Riccardo, AU - Chieregato,Arturo, Y1 - 2008/05/27/ PY - 2007/12/26/received PY - 2008/04/16/accepted PY - 2008/5/28/pubmed PY - 2009/1/14/medline PY - 2008/5/28/entrez SP - 729 EP - 40 JF - Neuroradiology JO - Neuroradiology VL - 50 IS - 8 N2 - INTRODUCTION: We sought to quantify perfusion changes associated to acute spontaneous intracerebral hemorrhage (SICH) by means of computed tomography perfusion (CTP) imaging. MATERIALS AND METHODS: We studied 89 patients with supratentorial SICH at admission CT by using CTP scanning obtained within 24 h after symptom onset. Regional cerebral blood flow (rCBF), cerebral blood volume (rCBV) and mean transit time (rMTT) levels were measured in four different regions of interest manually outlined on CT scan: (1) hemorrhagic core; (2) perihematomal low-density area; (3) 1 cm rim of normal-appearing brain tissue surrounding the perilesional area; and (4) a mirrored area, including the clot and the perihematomal region, located in the non-lesioned contralateral hemisphere. RESULTS: rCBF, rCBV, and rMTT mean levels showed a centrifugal distribution with a gradual increase from the core to the periphery (p < 0.0001). Perfusion absolute values were indicative of ischemia in hemorrhagic core, oligemia in perihematomal area, and hyperemia in normal-appearing and contralateral areas. Perihematomal rCBF and rCBV mean levels were higher in small (< or = 20 ml) than in large (>20 ml) hematomas (p < 0.01 and p < 0.02, respectively). CONCLUSION: Multi-parametric CTP mapping of acute SICH indicates that perfusion values show a progressive improvement from the core to the periphery. In the first 24 h, perihemorrhagic region was hypoperfused with CTP values which were not suggestive of ischemic penumbra destined to survive but more likely indicative of edema formation. These findings also argue for a potential influence of early amounts of bleeding on perihematomal hemodynamic abnormalities. SN - 0028-3940 UR - https://www.unboundmedicine.com/medline/citation/18504564/CT_perfusion_mapping_of_hemodynamic_disturbances_associated_to_acute_spontaneous_intracerebral_hemorrhage_ L2 - https://dx.doi.org/10.1007/s00234-008-0402-x DB - PRIME DP - Unbound Medicine ER -