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Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases.
Mol Nutr Food Res 2008; 52(8):885-97MN

Abstract

With regard to inflammatory processes, the main fatty acids of interest are the n-6 PUFA arachidonic acid (AA), which is the precursor of inflammatory eicosanoids like prostaglandin E(2) and leukotriene B(4), and the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA and DHA are found in oily fish and fish oils. EPA and DHA inhibit AA metabolism to inflammatory eicosanoids. They also give rise to mediators that are less inflammatory than those produced from AA or that are anti-inflammatory. In addition to modifying the lipid mediator profile, n-3 PUFAs exert effects on other aspects of inflammation like leukocyte chemotaxis and inflammatory cytokine production. Some of these effects are likely due to changes in gene expression, as a result of altered transcription factor activity. Fish oil has been shown to decrease colonic damage and inflammation, weight loss and mortality in animal models of colitis. Fish oil supplementation in patients with inflammatory bowel diseases results in n-3 PUFA incorporation into gut mucosal tissue and modification of inflammatory mediator profiles. Clinical outcomes have been variably affected by fish oil, although some trials report improved gut histology, decreased disease activity, use of corticosteroids and relapse.

Authors+Show Affiliations

Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK. pcc@soton.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18504706

Citation

Calder, Philip C.. "Polyunsaturated Fatty Acids, Inflammatory Processes and Inflammatory Bowel Diseases." Molecular Nutrition & Food Research, vol. 52, no. 8, 2008, pp. 885-97.
Calder PC. Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases. Mol Nutr Food Res. 2008;52(8):885-97.
Calder, P. C. (2008). Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases. Molecular Nutrition & Food Research, 52(8), pp. 885-97. doi:10.1002/mnfr.200700289.
Calder PC. Polyunsaturated Fatty Acids, Inflammatory Processes and Inflammatory Bowel Diseases. Mol Nutr Food Res. 2008;52(8):885-97. PubMed PMID: 18504706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases. A1 - Calder,Philip C, PY - 2008/5/28/pubmed PY - 2008/10/29/medline PY - 2008/5/28/entrez SP - 885 EP - 97 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 52 IS - 8 N2 - With regard to inflammatory processes, the main fatty acids of interest are the n-6 PUFA arachidonic acid (AA), which is the precursor of inflammatory eicosanoids like prostaglandin E(2) and leukotriene B(4), and the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). EPA and DHA are found in oily fish and fish oils. EPA and DHA inhibit AA metabolism to inflammatory eicosanoids. They also give rise to mediators that are less inflammatory than those produced from AA or that are anti-inflammatory. In addition to modifying the lipid mediator profile, n-3 PUFAs exert effects on other aspects of inflammation like leukocyte chemotaxis and inflammatory cytokine production. Some of these effects are likely due to changes in gene expression, as a result of altered transcription factor activity. Fish oil has been shown to decrease colonic damage and inflammation, weight loss and mortality in animal models of colitis. Fish oil supplementation in patients with inflammatory bowel diseases results in n-3 PUFA incorporation into gut mucosal tissue and modification of inflammatory mediator profiles. Clinical outcomes have been variably affected by fish oil, although some trials report improved gut histology, decreased disease activity, use of corticosteroids and relapse. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/18504706/Polyunsaturated_fatty_acids_inflammatory_processes_and_inflammatory_bowel_diseases_ L2 - https://doi.org/10.1002/mnfr.200700289 DB - PRIME DP - Unbound Medicine ER -